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http://dx.doi.org/10.12750/JARB.36.4.323

Case report of amniotic membrane derived-stem cells treatment for feline chronic obstructive pulmonary disease  

Kim, Taeho (AniCom Therapeutics Inc.)
Noh, Seul Ah (AniCom Therapeutics Inc.)
Ju, Junguk (AniCom Therapeutics Inc.)
Publication Information
Journal of Animal Reproduction and Biotechnology / v.36, no.4, 2021 , pp. 323-326 More about this Journal
Abstract
A cat who is a 15-year-old and spayed female visited an animal clinic with severe coughing symptoms. Since the cat's coughing symptoms had worsened from the age of 10 and X-rays showed a bronchial pattern in the lungs, it was diagnosed as Chronic Obstructive Pulmonary Disease (COPD). She received three injections of stem cells isolated from the amniotic membrane on days 0, 7, and 23. Although there was no improvement in the clinical findings on the x-ray, the number of coughing was significantly reduced. In addition, even after long-term follow-up post treatment for a month, she was stable with almost no coughing.
Keywords
amnion; COPD; feline; stem cells;
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1 Nemeth K, Keane-Myers A, Brown JM, Metcalfe DD, Gorham JD, Bundoc VG, Hodges MG, Jelinek I, Madala S, Mezey E. 2010. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc. Natl. Acad. Sci. U. S. A. 107:5652-5657.   DOI
2 Patel SA, Sherman L, Rameshwar P. 2008. Immunological properties of mesenchymal stem cells and clinical implications. Arch. Immunol. Ther. Exp. (Warsz.) 56:1-8.
3 Vidane AS, Souza AF, Sampaio RV, Bressan FF, Pieri NC, Martins DS, Meirelles FV, Ambrosio CE. 2014. Cat amniotic membrane multipotent cells are nontumorigenic and are safe for use in cell transplantation. Stem Cells Cloning 7:71-78.
4 Kavanagh H and Mahon BP. 2011. Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 66:523-531.   DOI
5 McEvoy CE and Niewoehner DE. 2000. Corticosteroids in chronic obstructive pulmonary disease. Clinical benefits and risks. Clin. Chest Med. 21:739-752.   DOI
6 Zhen G, Xue Z, Zhao J, Gu N, Tang Z, Zhang Z. 2010. Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells. Cytotherapy 12:605-614.   DOI
7 Chang YP, Lai CH, Lin CY, Chang YC, Lin MC, Chong IW, Sheu CC, Wei YF, Chu KA, Tsai JR, Chen YC. 2019. Mortality and vertebral fracture risk associated with long-term oral steroid use in patients with chronic obstructive pulmonary disease: a systemic review and meta-analysis. Chron. Respir. Dis. 16:1479973119838280.
8 De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Atala A. 2007. Isolation of amniotic stem cell lines with potential for therapy. Nat. Biotechnol. 25:100-106.   DOI
9 Quimby JM, Webb TL, Dow SW. 2013. Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies. Stem Cell Res. Ther. 4:48.   DOI
10 Trzil JE, Masseau I, Webb TL, Chang CH, Dodam JR, Liu H, Quimby JM, Reinero CR. 2016. Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study. J. Feline Med. Surg. 18:981-990.   DOI
11 Huh JW, Kim SY, Lee JH, Lee JS, Van Ta Q, Kim M, Oh YM, Lee SD. 2011. Bone marrow cells repair cigarette smoke-induced emphysema in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 301:L255-L266.   DOI
12 Lee H, Kang S, Park S, Lee S, Lee H, Koh P, Park J, Yeon S. 2011. Expression of HLA and mixed lymphocyte reaction of mesenchymal stem cells derived from human umbilical cord blood. J. Vet. Clin. 28:399-402.
13 Liu X, Kim H. 2016. Preclinical studies of mesenchymal stem cell (MSC) administration in chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis. PLoS One 11:e0157099.   DOI
14 Mathers CD and Loncar D. 2006. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 3:e442.   DOI
15 Guan XJ, Song L, Han FF, Cui ZL, Chen X, Xu WG. 2013. Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors. J. Cell. Biochem. 114:323-335.   DOI
16 McEvoy CE and Niewoehner DE. 1997. Adverse effects of corticosteroid therapy for COPD. A critical review. Chest 111:732-743.   DOI
17 Noh SA, Ju J. 2021. Case reports of amniotic membrane derived-cell treatment for feline chronic renal failure. J. Anim. Reprod. Biotechnol. 36:116-120.   DOI
18 Park HK, Cho KS, Park HY, Shin DH, Kim YK, Jung JS, Roh HJ. 2010. Adipose-derived stromal cells inhibit allergic airway inflammation in mice. Stem Cells Dev. 19:1811-1818.   DOI