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http://dx.doi.org/10.12750/JARB.36.4.183

The role of sonic hedgehog signaling pathway in in vitro oocyte maturation  

Lee, Sanghoon (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University)
Cho, Jongki (Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Animal Reproduction and Biotechnology / v.36, no.4, 2021 , pp. 183-188 More about this Journal
Abstract
In vitro maturation (IVM) of oocytes is the procedure where the immature oocytes are cultivated in a laboratory until they are mature. Since IVM oocytes generally have low developmental competence as compared to those matured in vivo, development of an optimal IVM culture system by fine-tuning culture conditions is crucial to maintain high quality. In-depth knowledge and a deep understanding of the in vivo physiology of oocyte maturation are pre-requisites to accomplish this. Within ovarian follicles, various signaling pathways that drive oocyte development and maturation regulate interaction between oocytes and surrounding somatic cells. This review discusses the sonic hedgehog (SHH) signaling pathway, which has been demonstrated to be intimately involved in folliculogenesis and oocyte maturation. Advances in elucidating the role of the SHH signaling pathway in oocyte maturation will aid attempts to improve the current inferior in vitro oocyte maturation system.
Keywords
in vitro oocyte maturation; ovarian follicle; sonic hedgehog signaling;
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