Browse > Article
http://dx.doi.org/10.12750/JARB.36.2.116

Case reports of amniotic membrane derived-cell treatment for feline chronic renal failure  

Noh, Seul Ah (AniCom Therapeutics Inc.)
Kim, Taeho (AniCom Therapeutics Inc.)
Ju, Junguk (AniCom Therapeutics Inc.)
Publication Information
Journal of Animal Reproduction and Biotechnology / v.36, no.2, 2021 , pp. 116-120 More about this Journal
Abstract
Three different cats who had chronic kidney disease (CKD) were treated for more than one month with fluid therapy in an animal clinic. Although this long-term treatment and hospitalization, there was no clinical improvement in clinical signs as well as serum biochemical indexes including blood urea nitrogen (BUN), creatinine (CREA), and phosphate (PHOS). All cases were then injected three times with allogeneic stem cells through an intravenous route for treatment on Day 0, 7, and 14 or 30. On the same day, clinical observation and blood tests for serum biochemistry were conducted together. Upon administrating stem cells to the CKD cats, clinical conditions and the indexes of BUN and CREA were clinically improved within normal ranges. Additionally, one of the cats who had the renal cysts presented clinical improvement with showing decreased cysts size than before.
Keywords
chronic kidney disease; feline; stem cells;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Mahiddine FY, Qamar AY, Kim MJ. 2020. Canine amniotic membrane derived mesenchymal stem cells exosomes addition in canine sperm freezing medium. J Anim. Reprod. Biotechnol. 35:268-272.   DOI
2 Polzin DJ. 2017. Chronic kidney disease. In: Ettinger SJ, Feldman EC, Cote E (Eds.), Textbook of Veterinary Internal Medicine. 8th ed, Elsevier, St. Louis, pp. 1938-1958.
3 Chan KW, Ping TY, Chou SJ, Zheng ZJ, Yang WC, Lai JM, Lo DY, Chang CC, Wu JT. 2014. Case report: treatment of an elderly dog with concurrent heart disease and acute uremia by hemodialysis. Taiwan Vet. J. 40:95-100.   DOI
4 De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. 2007. Isolation of amniotic stem cell lines with potential for therapy. Nat. Biotechnol. 25:100-106.   DOI
5 Filioli Uranio M, Valentini L, Lange-Consiglio A, Caira M, Guaricci AC, L'Abbate A, Catacchio CR, Ventura M, Cremonesi F, Dell'Aquila ME. 2011. Isolation, proliferation, cytogenetic, and molecular characterization and in vitro differentiation potency of canine stem cells from foetal adnexa: a comparative study of amniotic fluid, amnion, and umbilical cord matrix. Mol. Reprod. Dev. 78:361-373.   DOI
6 Quimby JM, Webb TL, Gibbons DS, Dow SW. 2011. Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: a pilot study. J. Feline Med. Surg. 13:418-426.   DOI
7 Vidane AS, Souza AF, Sampaio RV, Bressan FF, Pieri NC, Martins DS, Meirelles FV, Miglino MA, Ambrosio CE. 2014. Cat amniotic membrane multipotent cells are nontumorigenic and are safe for use in cell transplantation. Stem Cells Cloning 7:71-78.
8 Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P. 2004. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 8:R204-R212.   DOI
9 Cetinkaya B, Unek G, Kipmen-Korgun D, Koksoy S, Korgun ET. 2019. Effects of human placental amnion derived mesenchymal stem cells on proliferation and apoptosis mechanisms in chronic kidney disease in the rat. Int. J. Stem Cells 12:151-161.   DOI
10 Chung BH. 2019. Use of mesenchymal stem cells for chronic kidney disease. Kidney Res. Clin. Pract. 38:131-134.   DOI
11 Finco DR, Brown SA, Brown CA, Crowell WA, Cooper TA, Barsanti JA. 1999. Progression of chronic renal disease in the dog. J. Vet. Intern. Med. 13:516-528.   DOI
12 Lee HJ, Jeon RH, Park BJ, Jang SJ, Lee SL, Rho GJ, Kim SJ, Lee WJ. 2019a. Differentiation inductions altered telomere length and telomerase activity in human dental pulpderived mesenchymal stem cell. J. Anim. Reprod. Biotechnol. 34:93-99.   DOI
13 Moon SW, Lee HJ, Lee WJ, Ock SA, Lee SL. 2018. Trans-differentiation induction of human-mesenchymal stem cells derived from different tissue origin and evaluation of their potential for differentiation into corneal epithelial-like cells. J. Emb. Trans. 33:85-97.   DOI
14 Peired AJ, Sisti A, Romagnani P. 2016. Mesenchymal stem cell-based therapy for kidney disease: a review of clinical evidence. Stem Cells Int. 2016:4798639.
15 Jo JH, Kim KH, Kim TM. 2019. The potential of renal progenitor cells in kidney diseases: preclinical findings. J. Anim. Reprod. Biotechnol. 34:70-74.   DOI
16 Lee HJ, Park BJ, Jeon RH, Jang SJ, Son YB, Lee SL, Rho GJ, Kim SJ, Lee WJ. 2019b. Alteration of apoptosis during differentiation in human dental pulp-derived mesenchymal stem cell. J Anim. Reprod. Biotechnol. 34:2-9.   DOI
17 Webb TL, Quimby JM, Dow SW. 2012. In vitro comparison of feline bone marrow-derived and adipose tissue-derived mesenchymal stem cells. J. Feline Med. Surg. 14:165-168.   DOI
18 Quimby JM, Webb TL, Habenicht LM, Dow SW. 2013. Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies. Stem Cell Res. Ther. 4:48.   DOI