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http://dx.doi.org/10.5187/jast.2022.e19

Identification of candidate proteins regulated by long-term caloric restriction and feed efficiency in longissimus dorsi muscle in Korean native steer  

Jung, Usuk (Department of Animal Science and Technology, Sanghuh College of Life Sciences, Konkuk University)
Kim, Minjeong (Department of Animal Science and Technology, Sanghuh College of Life Sciences, Konkuk University)
Wang, Tao (Department of Animal Nutrition and Feed Science, Jilin Agricultural University)
Lee, Jae-Sung (Department of Animal Science and Technology, Sanghuh College of Life Sciences, Konkuk University)
Seo, Seongwon (Division of Animal and Dairy Sciences, College of Agriculture and Life Sciences, Chungnam National University)
Lee, Hong-Gu (Department of Animal Science and Technology, Sanghuh College of Life Sciences, Konkuk University)
Publication Information
Journal of Animal Science and Technology / v.64, no.2, 2022 , pp. 330-342 More about this Journal
Abstract
We aimed to investigate candidate proteins related to long-term caloric restriction and feed efficiency in bovine longissimus dorsi muscle (LM). A total of 31 Korean native steers were randomly distributed to ad libitum (n = 16) or caloric restriction group (n = 15) to conduct two feeding trials for 13 mon. In the first trial (10-18 mon of age), steers were fed with 100% ad libitum (NEg = 0.63 Mcal/kg) or caloric restriction (80% of the previous day's feed intake of ad libitum group). In the second trial (18-23 mon of age), the energy value of 100% ad libitum diet was 1.13 Mcal/kg NEg and those in caloric restriction group diet was 0.72 Mcal/kg NEg. At the endpoint of this experiment, in each group, 6 animals were selected with high (n = 3) or low feed efficiency (n = 3) to collect muscle tissue samples (6 animals/group). From muscle tissues of 23 mo of age, we excavated 9 and 12 differentially expressed (two-fold or more) proteins in a nutritional group and feed efficiency group using two-dimensional electrophoresis, respectively. Of these proteins, heat shock protein beta-6 was up-regulated in both the caloric restriction and the low feed efficiency group. In bovine embryonic fibroblasts, the mRNA expression of heat shock protein beta-6 increased after adipogenic differentiation, however, decreased after myogenic differentiation. Our data provide that heat shock protein beta-6 may be an adipogenic protein involved in the mechanism of caloric restriction and feed efficiency in the LM of the steer.
Keywords
Caloric restriction; Feed efficiency; Heat shock protein beta-6; Longissimus dorsi muscle; Proteomics; Steer;
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