Fecal microbiome shifts by different forms of copper supplementations in growing pigs |
Kim, Minji
(Animal Nutrition and Physiology Division, National Institute of Animal Science, Rural Development Administration)
Cho, Jae Hyoung (Department of Animal Resources Science, Dankook University) Seong, Pil-Nam (Animal Nutrition and Physiology Division, National Institute of Animal Science, Rural Development Administration) Jung, Hyunjung (Animal Nutrition and Physiology Division, National Institute of Animal Science, Rural Development Administration) Jeong, Jin Young (Animal Nutrition and Physiology Division, National Institute of Animal Science, Rural Development Administration) Kim, Sheena (Department of Animal Resources Science, Dankook University) Kim, Hyeri (Department of Animal Resources Science, Dankook University) Kim, Eun Sol (Department of Animal Resources Science, Dankook University) Keum, Gi Beom (Department of Animal Resources Science, Dankook University) Guevarra, Robin B. (Department of Animal Resources Science, Dankook University) Kim, Hyeun Bum (Department of Animal Resources Science, Dankook University) |
1 | Kim HB, Isaacson RE. The pig gut microbial diversity: understanding the pig gut microbial ecology through the next generation high throughput sequencing. Vet Microbiol. 2015;177:242-51. https://doi.org/10.1016/j.vetmic.2015.03.014 DOI |
2 | Mulder IE, Schmidt B, Stokes CR, Lewis M, Bailey M, Aminov RI, et al. Environmentally-acquired bacteria influence microbial diversity and natural innate immune responses at gut surfaces. BMC Biol. 2009;7:79. https://doi.org/10.1186/1741-7007-7-79 DOI |
3 | Megahed A, Zeineldin M, Evans K, Maradiaga N, Blair B, Aldridge B, et al. Impacts of environmental complexity on respiratory and gut microbiome community structure and diversity in growing pigs. Sci Rep. 2019;9:13773. https://doi.org/10.1038/s41598-019-50187-z DOI |
4 | Cai H, Thompson R, Budinich MF, Broadbent JR, Steele JL. Genome sequence and comparative genome analysis of Lactobacillus casei: insights into their niche-associated evolution. Genome Biol Evol. 2009;1:239-57. https://doi.org/10.1093/gbe/evp019 DOI |
5 | Zhang Y, Zhou J, Dong Z, Li G, Wang J, Li Y, et al. Effect of dietary copper on intestinal microbiota and antimicrobial resistance profiles of Escherichia coli in weaned piglets. Front Microbiol. 2019;10:2808. https://doi.org/10.3389/fmicb.2019.02808 DOI |
6 | Yang ZW, Aygul N, Liu XR, Zhao SS, Zhao WQ, Yang SL. Structure of copper chelate of 2-hydroxy-4-methylthiobutanoic acid as trace mineral additive in animal feeding. Chinese J Struct Chem. 2015;34:147-53. https://doi.org/10.14102/j.cnki.0254-5861.2011-0490 DOI |
7 | Shelton NW, Tokach MD, DeRouchey JM, Hill GM, Amachawadi RG, Nagaraja TG, et al. Effects of copper sulfate and zinc oxide on weanling pig growth and plasma mineral levels. Kansas Agric Exp Stn Res Rep. 2009;0:65-72. https://doi.org/10.4148/2378-5977.6785 DOI |
8 | Stahly TS, Cromwell GL, Monegue HJ. Effects of the dietary inclusion of copper and(or) antibiotics on the performance of weanling pigs. J Anim Sci. 1980;51:1347-51. https://doi.org/10.2527/jas1981.5161347x DOI |
9 | Miles RD, O'Keefe SF, Henry PR, Ammerman CB, Luo XG. The effect of dietary supplementation with copper sulfate or tribasic copper chloride on broiler performance, relative copper bioavailability, and dietary prooxidant activity. Poult Sci. 1998;77:416-25. https://doi.org/10.1093/ps/77.3.416 DOI |
10 | Lin G, Guo Y, Liu B, Wang R, Su X, Yu D, et al. Optimal dietary copper requirements and relative bioavailability for weanling pigs fed either copper proteinate or tribasic copper chloride. J Anim Sci Biotechnol. 2020;11:54. https://doi.org/10.1186/s40104-020-00457-y DOI |
11 | Gao Y, Yang W, Che D, Adams S, Yang L. Advances in the mechanism of high copper diets in restraining pigs growth. J Anim Physiol Anim Nutr. 2020;104:667-78. https://doi.org/10.1111/jpn.13213 DOI |
12 | Cao J, Henry PR, Guo R, Holwerda RA, Toth JP, Littell RC, et al. Chemical characteristics and relative bioavailability of supplemental organic zinc sources for poultry and ruminants. J Anim Sci. 2000;78:2039-54. https://doi.org/10.2527/2000.7882039x DOI |
13 | Predieri G, Tegoni M, Cinti E, Leonardi G, Ferruzza S. Metal chelates of 2-hydroxy-4-methylthiobutanoic acid in animal feeding: preliminary investigations on stability and bioavailability. J Inorg Biochem. 2003;95:221-4. https://doi.org/10.1016/S0162-0134(03)00067-9 DOI |
14 | Sun Q, Guo Y, Li J, Zhang T, Wen J. Effects of methionine hydroxy analog chelated Cu/Mn/ Zn on laying performance, egg quality, enzyme activity and mineral retention of laying hens. J Poult Sci. 2012;49:20-5. https://doi.org/10.2141/jpsa.011055 DOI |
15 | Perez VG, Waguespack AM, Bidner TD, Southern LL, Fakler TM, Ward TL, et al. Additivity of effects from dietary copper and zinc on growth performance and fecal microbiota of pigs after weaning. J Anim Sci. 2011;89:414-25. https://doi.org/10.2527/jas.2010-2839 DOI |
16 | Khan TJ, Ahmed YM, Zamzami MA, Mohamed SA, Khan I, Baothman OAS, et al. Effect of atorvastatin on the gut microbiota of high fat diet-induced hypercholesterolemic rats. Sci Rep. 2018;8:662. https://doi.org/10.1038/s41598-017-19013-2 DOI |
17 | Shetty SA, Marathe NP, Lanjekar V, Ranade D, Shouche YS. Comparative genome analysis of Megasphaera sp. reveals niche specialization and its potential role in the human gut. PLOS ONE. 2013;8:e79353. https://doi.org/10.1371/journal.pone.0079353 DOI |
18 | Liu Y, Ma YL, Zhao JM, Vazquez-Anon M, Stein HH. Digestibility and retention of zinc, copper, manganese, iron, calcium, and phosphorus in pigs fed diets containing inorganic or organic minerals. J Anim Sci. 2014;92:3407-15. https://doi.org/10.2527/jas.2013-7080 DOI |
19 | Flint HJ, Bayer EA. Plant cell wall breakdown by anaerobic microorganisms from the mammalian digestive tract. Ann N Y Acad Sci. 2008;1125:280-8. https://doi.org/10.1196/annals.1419.022 DOI |
20 | Espinosa CD, Fry RS, Usry JL, Stein HH. Copper hydroxychloride improves growth performance and reduces diarrhea frequency of weanling pigs fed a corn-soybean meal diet but does not change apparent total tract digestibility of energy and acid hydrolyzed ether extract. J Anim Sci. 2017;95:5447-54. https://doi.org/10.2527/jas2017.1702 DOI |
21 | Kopylova E, Noe L, Touzet H. SortMeRNA: fast and accurate filtering of ribosomal RNAs in metatranscriptomic data. Bioinformatics. 2012;28:3211-17. https://doi.org/10.1093/bioinformatics/bts611 DOI |
22 | Che D, Adams S, Wei C, Gui-Xin Q, Atiba EM, Hailong J. Effects of Astragalus membranaceus fiber on growth performance, nutrient digestibility, microbial composition, VFA production, gut pH, and immunity of weaned pigs. MicrobiologyOpen. 2019;8:e00712. https://doi.org/10.1002/mbo3.712 DOI |
23 | Guevarra RB, Hong SH, Cho JH, Kim BR, Shin J, Lee JH, et al. The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition. J Anim Sci Biotechnol. 2018;9:54. https://doi.org/10.1186/s40104-018-0269-6 DOI |
24 | Wang X, Tsai T, Deng F, Wei X, Chai J, Knapp J, et al. Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria. Microbiome. 2019;7:109. https://doi.org/10.1186/s40168-019-0721-7 DOI |
25 | Jondreville C, Revy PS, Jaffrezic A, Dourmad JY. Copper in pig nutrition: essential trace element, growth promoter, and its potential adverse effects on human nutrition and environment. Prod Anim. 2002;15:247-65. |
26 | Crespo-Piazuelo D, Migura-Garcia L, Estelle J, Criado-Mesas L, Revilla M, Castello A, et al. Association between the pig genome and its gut microbiota composition. Sci Rep. 2019;9:8791. https://doi.org/10.1038/s41598-019-45066-6 DOI |
27 | Li T, Chiang JYL. Bile acids as metabolic regulators. Curr Opin Gastroenterol. 2015;31:159-65. https://doi.org/10.1097/MOG.0000000000000156 DOI |
28 | Pastore P, Gallina A, Lucaferro P, Magno F. Cu(II)-amino acid and Cu(II)-peptide chelates in animal feeding: a semi-quantitative approach to characterize the commercial products and the limits of their structural integrity. Analyst. 1999;124:837-42. https://doi.org/10.1039/a901489f DOI |
29 | Espinosa CD, Stein HH. Digestibility and metabolism of copper in diets for pigs and influence of dietary copper on growth performance, intestinal health, and overall immune status: a review. J Anim Sci Biotechnol. 2021;12:13. https://doi.org/10.1186/s40104-020-00533-3 DOI |
30 | Das AK, Chowdhury NR, Nanda PK, Dandapat P, Batabyal S, Biswas S, et al. Role of gut microbiota modulation in health and production of pigs. Indian J Anim Health. 2020;59:75-88. https://doi.org/10.36062/ijah.59.2SPL.2020.75-88 DOI |
31 | Manto M. Abnormal copper homeostasis: mechanisms and roles in neurodegeneration. Toxics. 2014;2:327-45. https://doi.org/10.3390/toxics2020327 DOI |
32 | Cromwell GL, Lindemann MD, Monegue HJ, Hall DD, Orr DE Jr. Tribasic copper chloride and copper sulfate as copper sources for weanling pigs. J Anim Sci. 1998;76:118-23. https://doi.org/10.2527/1998.761118x DOI |
33 | Predieri G, Elviri L, Tegoni M, Zagnoni I, Cinti E, Biagi G, et al. Metal chelates of 2-hydroxy-4-methylthiobutanoic acid in animal feeding: part 2: further characterizations, in vitro and in vivo investigations. J Inorg Biochem. 2005;99:627-36. https://doi.org/10.1016/j.jinorgbio.2004.11.011 DOI |
34 | Concarr MJ, O'Rourke R, Murphy RA. The effect of copper source on the stability and activity of α-tocopherol acetate, butylated hydroxytoulene and phytase. SN Appl Sci. 2021;3:564. https://doi.org/10.1007/s42452-021-04563-y DOI |
35 | Schokker D, Zhang J, Zhang L, Vastenhouw SA, Heilig HGHJ, Smidt H, et al. Early-life environmental variation affects intestinal microbiota and immune development in new-born piglets. PLOS ONE. 2014;9:e100040. https://doi.org/10.1371/journal.pone.0100040 DOI |
36 | Adams S, Che D, Hailong J, Zhao B, Rui H, Danquah K, et al. Effects of pulverized oyster mushroom (Pleurotus ostreatus) on diarrhea incidence, growth performance, immunity, and microbial composition in piglets. J Sci Food Agric. 2019;99:3616-27. https://doi.org/10.1002/jsfa.9582 DOI |
37 | Chen Z, Mayer LM, Weston DP, Bock MJ, Jumars PA. Inhibition of digestive enzyme activities by copper in the guts of various marine benthic invertebrates. Environ Toxicol Chem. 2002;21:1243-8. https://doi.org/10.1002/etc.5620210618 DOI |
38 | Kumar J, Sathua KB, Flora SJS. Chronic copper exposure elicit neurotoxic responses in rat brain: assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and neurobehavioral parameters. Cell Mol Biol. 2019;65:27-35. https://doi.org/10.14715/cmb/2019.65.1.5 DOI |
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