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http://dx.doi.org/10.5187/jast.2021.e39

Comparative analysis of dietary exosome-derived microRNAs from human, bovine and caprine colostrum and mature milk  

Yun, Bohyun (Department of Functional Food and Biotechnology, Jeonju University)
Kim, Younghoon (Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University)
Park, Dong June (Korea Food Research Institute)
Oh, Sangnam (Department of Functional Food and Biotechnology, Jeonju University)
Publication Information
Journal of Animal Science and Technology / v.63, no.3, 2021 , pp. 593-602 More about this Journal
Abstract
Mammalian milk including microRNAs (miRNAs) as a novel class of noncoding RNAs, that can be transferred to infants and it plays on a critical role in biological functions such as immune regulation and development. However, the origin and functional importance of milk-derived miRNAs are still undetermined. This study applied RNA sequencing to explore the featured profiles of miRNA expression in colostrum and mature milk-originated exosomes from human, bovine, and caprine milk. These dietary exosome-derived miRNAs are highly conserved in human, bovine and caprine milk. Interestingly, abundant miRNAs expressed in human milk are similarly conserved across species. In addition, we confirmed that immune-related miRNAs (miR-30a-5p, miR-22-3p, and miR-26a) are commonly observed in the colostrum and mature milk of cows and caprines as well as humans. Our results provide new insights and resources for investigating the functionality of immune-associated miRNAs and evaluating physiological and biological condition in human, bovine and caprine milk as biomarkers.
Keywords
Colostrum; Mature milk; Dietary exosome; MicroRNA; Mammals;
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