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http://dx.doi.org/10.5187/jast.2020.62.3.306

Genome-wide association study to identify canine hip dysplasia loci in dogs  

Kang, Ji Min (Division of Animal and Dairy Science, Chungnam National University)
Seo, Dongwon (Division of Animal and Dairy Science, Chungnam National University)
Lee, Soo Hyun (Division of Animal and Dairy Science, Chungnam National University)
Lee, Doo Ho (Division of Animal and Dairy Science, Chungnam National University)
Kim, Yeong Kuk (Division of Animal and Dairy Science, Chungnam National University)
Choi, Bong Hwan (Animal Genomics & Bioinformatics Division, National Institute of Animal Science, RDA)
Lee, Seung Hwan (Division of Animal and Dairy Science, Chungnam National University)
Publication Information
Journal of Animal Science and Technology / v.62, no.3, 2020 , pp. 306-312 More about this Journal
Abstract
Korean army dogs are raised for special purposes and have contributed much to society. However, several diseases occur in dogs. Canine hip dysplasia (CHD) is a musculoskeletal disorder that occurs frequently in Korean army dogs and interferes with their activities. If we could control CHD, this would have a positive effect on their performance. This study performed a genome-wide association study (GWAS) in 69 Korean army dogs to find significant loci for CHD using 170K single nucleotide polymorphisms (SNPs). CHD was classified according to the Norberg angle criterion. The control group comprised 62 dogs classified as relatively normal, and 7 dogs with severe CHD formed the case group. From the GWAS analysis, we concluded that SNPs present on chromosome 4 might have a significant impact on the overall expression of canine hip dysplasia.
Keywords
Single nucleotide polymorphism (SNP); Canine hip dysplasia (CHD); Genome-wide association study (GWAS);
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