AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside) Decreases Protein Synthesis in C2C12 Myotubes Cultured in High Glucose Media
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Park, Chang-Seok
(National Institute of Animal Science, R.D.A)
Kim, Jae-Hwan (National Institute of Animal Science, R.D.A) Oh, Young-Kyoon (National Institute of Animal Science, R.D.A) Kim, Kyoung-Hoon (National Institute of Animal Science, R.D.A) Choi, Chang-Weon (Department of Animal Resource, Daegu University) Cho, Eun-Seok (National Institute of Animal Science, R.D.A) Jeong, Yong-Dae (National Institute of Animal Science, R.D.A) Park, Sung-Kwon (National Institute of Animal Science, R.D.A) |
1 | Bolster, D. R., Crozier, S. J., Kimball, S. R. and Jefferson, L. S. 2002. AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling. pp. 23977-23980. |
2 | Fulco, M., Cen, Y., Zhao, P., Hoffman, E. P., McBurney, M. W., Sauve, A. A. and Sartorelli, V. 2008. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell 14, 661-673. DOI ScienceOn |
3 | Garlick, P. J., Fern, M. and Preedy, V. R. 1983. The effect of insulin infusion and food intake on muslce protein synthesis in postabsorptive rats. Biochem. J 210, 669-676. DOI |
4 | Glickman, M. H. and Ciechanover, A. 2002. The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction. pp. 373-428. |
5 | Hahn-Windgassen, A., Nogueira, V., Chen, C. -C., Skeen, J. E., Sonenberg, N. and Hay, N. 2005. Akt activates mTOR by regulating cellular ATP and AMPK activity. p. M502876200. |
6 | Hardie, D. G. 2007. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 8, 774-785. DOI ScienceOn |
7 | Hardie, D. G., Carling, D. and Carlson, M. 1998. THE AMPACTIVATED/ SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell? Annu. Rev. Biochem. 67, 821-855. DOI ScienceOn |
8 | McKinnell, I. W. and Rudnicki, M. A. 2004. Molecular Mechanisms of Muscle Atrophy. Cell 119, 907-910. DOI ScienceOn |
9 | Merrill, G. F., Kurth, E. J., Hardie, D. G. and Winder, W. W. 1997. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol Endocrinol Metab 273, E1107-1112. DOI |
10 | Nakashima., K. and Yakabe., Y. 2007. AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes. Biosci. Biotechnol. Biochem. 71, 1650-1656. DOI ScienceOn |
11 | Sarbassov, D. D., Ali, S. M. and Sabatini, D. M. 2005. Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17, 596-603. DOI ScienceOn |
12 | Sidossis, L. S., Stuart, C. A., Shulman, G. I., Lopaschuk, G. D. and Wolfe, R. R. 1996. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. The Journal of Clinical Investigation 98, 2244-2250. DOI ScienceOn |
13 | Williamson, D. L., Bolster, D. R., Kimball, S. R. and Jefferson, L. S. 2006. Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. pp. E80-89. |
14 | Wullschleger, S., Loewith, R. and Hall, M. N. 2006. TOR Signaling in Growth and Metabolism. Cell 124, 471-484. DOI ScienceOn |
15 | Yeshao, W., Gu, J., Peng, X., Nairn, A. C. and Nadler, J. L. 2005. Elevated glucose activates protein synthesis in cultured cardiac myocytes. Metabolism 54, 1453-1460. DOI ScienceOn |
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