Supplementation of Either Conjugated Linoleic Acid or γ-linolenic Acid with or without Carnitine to Pig Diet Affect Flavor of Pork and Neutrophil Phagocytosis |
Lee, Jun-Yeob
(College of Animal Life Sciences, Kangwon National University)
Cha, Keun-Hwan (Korea Feed Ingredients Association) Chae, Byong-Jo (College of Animal Life Sciences, Kangwon National University) Ohh, Sang-Jip (College of Animal Life Sciences, Kangwon National University) |
1 | Ge, J., Wang, Y., Feng, Y., Liu, H., Cui1, X., Chen, F., Tai1, G. and Liu1, Z. 2009. Direct effects of activin A on the activation of mouse macrophage. Cell. Mol. Immunol. 6: 129-133. DOI ScienceOn |
2 | Gonzalez, D. 2008. Effect of dietary fatty acids, time of feeding and immune response in poultry. MS thesis, Oregon state Univ. USA. |
3 | Greer, W., Boisclair, R., Stankiewicz, M., McAnulty, W., Jay, P., and Sykes, R. 2009. Leptin concentrations and the immunemediated reduction of feed intake in sheep infected with the nematode Trichostrongylus colubriformis. Br. J. Nutr. 102:954-957. DOI ScienceOn |
4 | Hanczakkowski, P., Szymczyk, B. and Hanczakowska, E. 2009. Fatty acid profile and cholesterol content of meat from pigs fed different fats. Ann. Anim. Sci. 9:157-163. |
5 | Hansen, L., Mikkelsen, L., Agerhem, H., Laue, A., Jensen, M. and Jensen, B. 2000. Effect of fermented liquid food and zinc bacitracin on microbial metabolism in the gut and sensoric profile of M. longissimus dorsi from entire male and female pigs. Anim. Sci. 71:65-80. DOI |
6 | He, M. L., Ishikawa, S. and Hidari, H. 2005. Fatty acid profiles of various muscles and adipose tissues from fattening horses in comparison with beef cattle and pigs. Asian-Aust. J. Anim. Sci. 18:1655-1661. 과학기술학회마을 DOI |
7 | Hemat, R. 2004. Principle of Orthomolecularism. Urotext. ISBN 1-903737-06-0. |
8 | Hoppel, C. 2003. The role of carnitine in normal and altered fatty acid metabolism. Am. J. Kidney Dis. 41S:4-12. |
9 | Hoque, A., Katoh, K. and Suzuki, K. 2009. Genetic associations of residual feed intake with serum insulin-like growth factor-I and leptin concentrations, meat quality, and carcass cross sectional fat area ratios in Duroc pigs J. Anim. Sci. 87:3069-3075. DOI ScienceOn |
10 | Dugan, M. E. R., Aalhus, J. L., Schaefer, A. L. and Kramer, J. K. G. 1997. The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Can. J. Anim. Sci. 77:723-725. DOI ScienceOn |
11 | Dugan, M. E. R., Aalhus, J. L., Jeremiah, L. E., Kramer, J. K. G. and Schaefer, A. L. 1999. The effects of feeding conjugated linoleic acid on subsequent pork quality. Can. J. Anim. Sci., 79:45-51. DOI |
12 | Ecker, J., Liebisch, G., Scherer, M. and Schmitz, G. 2010. Differential effects of conjugated linoleic acid isomers on macrophage glycerophospholipid metabolism. J. Lipid Res. 51:2686-2694. DOI ScienceOn |
13 | Eggert, J. M., Belury, M. A., Kempa-Steczko, A., Mills, S. E. and Schinckel, A. P. 2001. Effects of conjugated linoleic acid on the belly firmness and fatty acid composition of genetically lean pigs. J Anim. Sci. 79:2866-2872. DOI |
14 | Ellis, M. and Mckeith, F. 2010. Nutritional influences on pork quality. http://www.extension.org/pages/27434/nutritionalinfluences-on-pork-quality. |
15 | Fenton, T. W. and Fenton, M. 1979. An improved procedure for the determination of chromic oxide in feed and feces. Can. J. Anim. Sci. 59, 631-634. DOI |
16 | Folch, J., Lees, M. and Sloane Stanley, G. H. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509. |
17 | Fukushima, M., Ohhashi, T., Ohno, S., Saitoh, H., Sonoyama, K., Shimada, K., Sekikawa, M. and Nakano, M. 2001. Effects of diets enriched in n-6 or n-3 fatty acids on cholesterol metabolism in older rats chronically fed a cholesterol-enriched diet. Lipids. 36:261-266. DOI ScienceOn |
18 | Furuse, M., Okada, R., Kita, K., Asakura, K. and Okumura, J. 1992. Effect of gamma linolenic acid on lipid metabolism of laying hens. Comp. Biochem. Physiol. A 101: 167-169. DOI ScienceOn |
19 | Bertol, T. M., Ellis, M., Hamilton, D. N., Johnson, E. W. and Ritter, M. J. 2005. Effects of dietary supplementation with L-carnitine and fat on blood acid-base responses to handling in slaughter weight pigs. J. Anim. Sci. 83:75-81. DOI |
20 | Bee, G. 2001. Dietary conjugated linoleic acids affect tissue lipid composition but not de novo lipogenesis in finishing pigs. Anim. Res. 50:383-399. DOI ScienceOn |
21 | Bontempo, V., Sciannimanico, D., Pastorelli, G., Rossi, R., Rosi, F. and Corino, C. 2004. Dietary conjugated linoleic acid positively affects immunologic variables in lactating sows and piglets. J. Nutr. 134:817-824. DOI |
22 | Cameron, N. and Enser, M. 1991. Fatty acid composition of lipid in longissimus dors imuscle of Duroc and British Landrace pigs and its relationship with eating quality. Meat Science 29:295-307. DOI ScienceOn |
23 | Carroll, J. A. and Allee, G. L. 2009. Hormonal control of feed intake in swine. In) Voluntary Feed Intake in Pigs. pp. 155-187 ISBN 978-90-8686-096-8. |
24 | Chandak, P., Radovic, B. Aflaki, E., Kolb, D., Buchebner, M., Frohlich, E., Magnes, C., Sinner, F., Haemmerle, G., Zechner, R., Tabas, I., Levak-Frank, S. and Kratky, D. 2010. Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J. Biol. Chem. 285:20192-20201. DOI ScienceOn |
25 | Chung, S., Kong, S., Seong, K. and Cho, Y. 2002. -Linolenic acid in borage oil reverses epidermal hyperproliferation in Guinea pigs. J. Nutr. 132: 3090-3097. DOI |
26 | Dodson, V., Hausman, G., Guan, L., Du, M., Rasmussen, T., Poulos, S., Mir, P., Bergen, W., Fernyhough, M., McFarland, D., Rhoads, R., Soret, B., Reecy, J., Velleman, S. and Jiang, Z. 2010. Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research. Int. J. Biol. Sci. 6:691-699. |
27 | Yin, J. D., Shang, X. G., Li, D. F., Wang, F. L., Guan, Y. F. and Wang, Z. Y. 2008. Effects of dietary conjugated linoleic acid on the fatty acid profile and cholesterol content of egg yolks from different breeds of layers. Poult. Sci. 87:284-290. DOI ScienceOn |
28 | Dugan, M. E. R., Aalhus, J. L. and Kramer, J. K. G. 2004. Conjugated linoleic acid pork research. Am. J. Clin. Nutr. 79 (suppl):1212S-1216S. DOI |
29 | A. O. A. C. 1990. Official Methods of Analysis (15th ed.). Association of Official Analytical Chemists. Washington, D.C. |
30 | Apple, J., Sawyer, J. T., Maxwell, C. V., Yancey, J. W. S., Frank, J. W., Woodworth, J. C. and Musser, R. E. 2011. Effects of l-carnitine supplementation on quality characteristics of fresh pork bellies from pigs fed three levels of corn oil. J. Anim. Sci. on line. doi:10.2527/jas.2011-3933. DOI ScienceOn |
31 | Witte, V. C., Krause, G. F. and Bailey, M. E. 1970. A new extraction method for determining 2-thiobarbituric acid values of pork and beef during storage. J. Food Sci. 35: 582585. DOI |
32 | Takada, R. and Saitoh, M. 1998. Effect of dietary gamma-linolenic acid-enriched oil on backfat thickness and liver fatty acid degrading enzyme activity in growing pigs. Anim. Sci. Technol. 69:433-438. |
33 | Teye, G., Sheard, P., Whittington, F., Nute, G., Stewart, A. and Wood, J. 2006. Influence of dietary oils and protein level on pork quality. 1. Effects on muscle fatty acid composition, carcass, meat and eating quality. Meat Sci. 73:157-165. DOI ScienceOn |
34 | Weaver, K., Ivester, P., Seeds, M., Case, D., Arm, J. and Chilton, F. 2009. Effect of dietary fatty acids on inflammatory gene expression in healthy humans J. Biol. Chem. 284:15400-15407. DOI ScienceOn |
35 | White, H. M., Richert, B. T., Radcliffe, J. S., Schinckel, A. P., Burgess, J. R., Koser, S. L., Donkin, S. S. and Latour, M. 2009. Feeding conjugated linoleic acid partially recovers carcass quality in pigs fed dried corn distillers grains with soluble. J. Anim Sci. 87:157-166. DOI |
36 | Wiegand, B. R., Parrish, F. C., Swan, J. E., Larsen, S. T. and Baas, T. J. 2001. Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves certain aspects of meat quality in stress-genotype pigs. J. Anim. Sci. 79:2187-2195. DOI |
37 | Xi, L., Brown, K., Woodworth, J., Shim, K., Johnson, B. and Odle, J.2008. Maternal dietary L carnitine supplementation influences fetal carnitine status and stimulates carnitine palmitoyl transferase and pyruvate dehydrogenase complex activities in swine. J. Nutr. 138:2356-2362. DOI ScienceOn |
38 | Yaqoob, P. 2004. Fatty acids and the immune system: from basic science to clinical applications. Proc. Nutr. Soc. 63:89-104. DOI ScienceOn |
39 | Romans, J. R., Johnson, R. C., Wulf, D. M., Libal, G. W. and Costello, W. J. 1995a. Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: I. Dietary level of flaxseed. J. Anim. Sci. 73:1982-1986. DOI |
40 | Romans, J. R., Johnson, R. C., Wulf, D. M., Libal, G. W. and Costello, W. J. 1995b. Effects of ground flaxseed in swine dietson pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: II. Duration of 15% dietary flaxseed. J. Anim. Sci. 73:1987-1999. DOI |
41 | Song, D. H., Kang, J. H., Lee, G. S., Jeung, E. B. and Yang, M. P. 2007. Upregulation of tumor necrosis factor- expression by trans10-cis12 conjugated linoleic acid enhances phagocytosis of RAW macrophages via a peroxisome proliferator-activated receptor -dependent pathway. Cytokine. 37:227-235. DOI ScienceOn |
42 | SAS Institute. 2003. SAS Stat User's Guide. Version 8. SAS Institute Inc., Cary, NC. |
43 | Selvaraj, R. and Cherian, G. 2004. Changes in delayed type hypersensitivity, egg antibody content and immune cell fatty acid composition of layer birds fed conjugated linoleic acid, n-6 or n-3 fatty acids. Can. J. Anim. Sci. 84:221-228. DOI ScienceOn |
44 | Sioutis, S., Coates, A., Buckley, J., Murphy, T., Channon, H. and Howe, P. 2008. N-3 enrichment of pork with fish meal: Effects on production and consumer acceptability. Eur. J. Lipid Sci. Technol. 110:701-706. DOI ScienceOn |
45 | Stachowska E., Baskiewicz-Masiuk, M., Dziedziejko, V., Adler, G., Bober, J., Machalinski, B. and Chlubek, D. 2007. Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expression. Lipids. 42: 707-716. DOI |
46 | Sukhija, P. S. and Palmquist, D. L. 1988. Rapid method for determination of total fatty acid contents and composition of feedstuffs and feces. J. Agric. Food Chem. 36:1202-1206. DOI |
47 | Owen, K. Q., Ji, H., Maxwell, C. V., Nelssen, J. L., Goodband, R. D., Tokach, M. D., Tremblay, G. C. and Koo, S. I. 2001. Dietary L-carnitine suppresses mitochondrial branched chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine. J. Anim. Sci. 79:3104-3112. DOI |
48 | Peris, M. and Escuder-Gilabert, L. 2009. A 21st century technique for food control: Electronic nose. Analytica Chimica Acta. 638:1-15. DOI ScienceOn |
49 | Palombo, J. D., DeMichele, S. J., Liu, J. W., Bistrian, B. R. and Huang, Y. S. 2000. Comparison of growth and fatty acid metabolism in rats fed diets containing equal levels of gamma-linolenic acid from high gamma-linolenic acid canola oil or borage oil. Lipids. 35:975-981. DOI ScienceOn |
50 | Peiretti, P. and Meineri, G. 2011. Effects of diets with increasing levels of Spirulina platensis on the carcass characteristics, meat quality and fatty acid composition of growing rabbits. Livestock Sci. doi:10.1016/j.livsci.2011.03.31. DOI |
51 | Raff, M., Tholstrup, T., Basu, S., Nonboe, P., Sorensen, M. and Straarup, E. 2008. Diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men. J. Nutr. 138:509514. DOI |
52 | Ramsey, T. G., Evock-Clover, C. M., Steele, N. C. and Azain, M. J. 2001. Dietary conjugated linoleic acid alters fatty acid composition of pig skeletal muscle and fat. J. Anim. Sci. 9:2152-2161. |
53 | Riediger, N. D., Othman, R. A., Suh, M. and Moghadasian, M. H. 2009. A systemic review of the roles of n-3 fatty acids in health and disease. J. Am. Diet. Assoc. 109:668-679. DOI ScienceOn |
54 | Roche, M., Noone, E., Sewter, C., Mc Bennett, S., Savage, D., Gibney, M., O'Rahilly, S. and Vidal-Puig, A. 2002. Isomerependent metabolic effects of conjugated linoleic acid. Diabetes 51:2037-2044. DOI ScienceOn |
55 | Migdal, W., Pasciak, P., Wojtysiak, D., Barowicz, T., Pieszka, M. and Pietras, M. 2004. The effect of dietary CLA supplementation on meat and eating quality, and the histochemical profile of the m. longissimus dorsi from stress susceptible fatteners slaughtered at heavier weights. Meat Sci., 66:863-870. DOI ScienceOn |
56 | Moreno, R., Miller, P., Burkey, T., Jones, S., Cuppett, S., Carr, T., Jones, T. and Diedrichsen, R. 2008. The effect of corn distillers dried grain with solubles (DDGS) on carcass characteristics and pork quality. Nebraska Swine Report. 2008:8-11. |
57 | Miles, E., Banerjee, T., Dooper, M., M'Rabet, L., Graus, Y. and Calder, P. 2004. The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. Br. J. Nutr. 91:893-903. DOI ScienceOn |
58 | Miner, L., Cederbergy, C., Chenz, X., Baile, C. and Nielsenyy, M. 2001. Dietary conjugated linoleic acid (CLA) and body fat changes. Nebraska Swine Report:27-28. |
59 | Moon, H. K., Lee, S. D., Jung, H. J., Kim, Y. H., Park, J. C., Ji, S. Y., Kim, C. D., Kwon, O. S. and Kim, I. C.. 2008. Effects of dietary protein level and supplementation of conjugated linoleic acid on growth performance and meat quality parameters in finishing pigs. J. Anim. Sci. Technol. 50:695-704. DOI ScienceOn |
60 | Ngapo, T. and Gariepy, C. 2008. Factors affecting the eating quality of pork. Crit. Rev. Food Sci. Nutr. 48:599-633. DOI ScienceOn |
61 | N. R. C. 1998. Nutrients Requirements of Swine. 10th ed. National Academy Science-National Research Council. Washington, D.C. |
62 | O'Shea. M., Bassaganya-Riera, J. and Mohede, I. 2004. Immunomodulatory properties of conjugated linoleic acid. Am. J. Clin. Nutr. 79: 1199S-1206S. DOI |
63 | Liu, B. F., Miyata, S., Kojima, H., Uriuhara, A., Kusunoki, H., Suzuki, K., and Kasuga, M. 1999. Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products. Diabetes. 48:2074-2082. DOI ScienceOn |
64 | Malaguarnera, M., Vacante, M., Avitabile, T., Malaguarnera, M., Cammalleri, L. and Motta, M. 2009. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. Am. J. Clin. Nutr. 89:71-76. DOI |
65 | Liu, J. W., DeMichele, S. J., Palombo, J. T., Chuang, L. T., Hastilow, C., Jr. Bobik, E. and Huang, Y. S. 2004. Effect of long-term dietary supplementation of high-gamma-linolenic canola oil versus borage oil on growth, hematology, serum biochemistry, and N-6 fatty acid metabolism in rats. J Agric Food Chem. 52:3960-3966. DOI ScienceOn |
66 | Lykkesfeldt, J. and Svendsen, O. 2007. Oxidants and antioxidants in disease: oxidative stress in farm animals. Vet. J. 173:502-511. DOI ScienceOn |
67 | McLeod, R., LeBlanc, A., Langille, M., Mitchell, P. and Currie, D. 2004. Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism. Am. J. Clin. Nutr. 79: 1169S-1174S. DOI |
68 | Martin, D., Antequera, T., Gonzalez, E., Lopez-Bote, C. and Ruiz, J. 2007. Changes in the fatty cid profile of the subcutaneous fat of swine throughout fattening as affected by dietary conjugated linoleic acid and monounsaturated fatty acids. J. Agric. Food Chem. 55:10820-10826. DOI ScienceOn |
69 | Maw, S. J., Fowler, V., Hamilton, M. and Petchey, A. 2001. Effect of husbandry and housing of pigs on the organoleptic properties of bacon. Livest. Prod. Sci., 68:119-130. DOI ScienceOn |
70 | Menendez, A., Colomer, R. and Lupu, R. 2005. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of -linolenic acid-induced toxicity to tumor cells: an extensionto Nwankwo's hypothesis, Hypotheses 64:337-341. DOI ScienceOn |
71 | Izgut-Uysal V. N., Agaç, A., Karadogan, I. and Derin, N. 2004. Peritoneal macrophages function modulation by L-carnitine in aging rats. Aging Clin. Exp. Res.16:337-341. DOI |
72 | Kang, K. W. and Pariza, M. W. 2001. Trans-10,cis-12-conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. Biochem. Biophy. Res. Comm. 287:377-382. DOI ScienceOn |
73 | James, B. W. 2009. Effects of dietary L-carnitine on finishing pig growth performance, meat quality and stress parameters during handling. Ph. D. Dissertation. KSU. USA. |
74 | Jonsdottir, R., Valdimarsdottir, T., Baldursdottir, B. and Thorkelsson, G. 2003. Influence of low fat fishmeal on fatty acid composition and sensory quality of pork. J. Muscle Foods. 14:51-56. DOI ScienceOn |
75 | Joo, S. T., Lee, J. I., Ha, Y. L. and Park, G. B. 2002. Effects of dietary conjugated linoleic acid on fatty acid composition, lipid oxidation, color, and water-holding capacity of pork loin. J. Anim. Sci. 80:108-112. DOI |
76 | Kew, S., Banerjee, T., Minihane, A. M., Finnegan, Y. E., Williams, C. M. and Calder, P. C. 2003. Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthfree-living subjects aged 25-72 y. Am. J. Clin. Nutr. 77:1278-1286. DOI |
77 | Latour, M. A., Gerrard, D. E. and Shipp, T. E. 2003. Evaluating growth and carcass characteristics of barrows fed a triglyceride form of conjugated linoleic acid. Purdue Univ. Swine Res. Rep. 2003:68-71. |
78 | Lima-Salgado, T. M., Sampaio, S. C., Cury-Boaventura, M. F. and Curi, R. 2011. Modulatory effect of fatty acids on fungicidal activity, respiratory burst and TNF- and IL-6 production in J774 murine macrophages. Br. J. Nutr. 105:1173-1179. DOI ScienceOn |
79 | Lin, Y., Li, W., Ling, J. and Zhou, L. 2010. Effect of carnitine onserum cholesterol of alcoholic cardiomyopathy dogs. Eur. J. Lipid Sci. Technol. 112:821-827. DOI ScienceOn |