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http://dx.doi.org/10.5187/JAST.2007.49.5.577

Analysis of the ADSF/resistin Gene Polymorphism Associated with Carcass Traits in Hanwoo  

Park, J.A. (Department of Animal Science and Biotechnology, Jinju National University)
Kang, H.K. (Department of Animal Science and Biotechnology, Jinju National University)
Chae, E.J. (Department of Animal Science and Biotechnology, Jinju National University)
Seo, K.S. (National Institute of Animal Science, RDA)
Kim, S.H. (Department of Biology, Kyung Hee University)
Yun, C.H. (School of Agricultural Biotechnology, Seoul National University)
Moon, Y.S. (Department of Animal Science and Biotechnology, Jinju National University)
Publication Information
Journal of Animal Science and Technology / v.49, no.5, 2007 , pp. 577-584 More about this Journal
Abstract
Adipocyte-specific secretory factor(ADSF)/resistin, an hormone, is a small cysteine-rich protein secreted from adipose tissue and ADSF/resistin has been implicated in modulating adipogenesis in human and rodents. Although the exact role of ADSF/resistin in bovine has not been identified, it may have directly or indirectly involved in adipocyte differentiation. The objective of this study was to investigate its DNA polymorphism associated with carcass traits in Korean Native Cattle(Hanwoo). To investigate DNA polymorphism in Hanwoo ADSF/resistin gene, blood samples were taken from 295 Hanwoo steers belonging to progeny testing at Hanwoo Improvement Center in Korea. Seven single nucleotide polymorphisms(SNPs) were found in intron regions but not in any other regions including promoter (1.7kb) and 4 exons. The highest frequency among SNPs was C186A(0.16/0.84) following G964A (0.156/0.884). The significant correlation(P<0.05) between the SNPs and economic traits was found on 764Ains associated with marbling but not from any other SNPs determined.  A computer simulation was also conducted to assess the efficiency of marker assisted selection(MAS) versus the conventional breeding scheme.  Results revealed that MAS was more efficient as a breeding tool compared to the conventional. In conclusion, ADSF/Resistin gene is one of candidate genes to evaluate the quality, especially marbling score, in Hanwoo.
Keywords
ADSF/resistin; Hanwoo; Carcass trait; SNP;
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