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http://dx.doi.org/10.5187/JAST.2007.49.4.437

Associations of the Porcine Melanocortin-4 Receptor (MC4R) Gene with Growth Traits in Duroc Pigs  

Cho, K.H. (National Institute of Animal Science, RDA)
Kim, M.J. (National Institute of Animal Science, RDA)
Choi, B.H. (National Institute of Animal Science, RDA)
Jeon, G.J. (National Institute of Animal Science, RDA)
Ryu, J.W. (National Institute of Animal Science, RDA)
Jung, H.J. (National Institute of Animal Science, RDA)
Kim, I.C. (National Institute of Animal Science, RDA)
Lee, H.K. (Genomic Informatics Center, Hankyong National University)
Jeon, G.J. (Genomic Informatics Center, Hankyong National University)
Publication Information
Journal of Animal Science and Technology / v.49, no.4, 2007 , pp. 437-442 More about this Journal
Abstract
The melanocortin-4 receptor(MC4R) is virtually expressed in all brain regions and plays an important role in energy homeostasis in mammals. MC4R has been intensively studied as a trait gene controlling economically important traits, such as growth and feed conversion, etc. Six hundreds and sixty Duroc pigs were genotyped for the MC4R locus and analyzed their relationships with breeding values for average daily gain(ADG), backfat thickness(BF), days to 90kg(D90) and feed conversion(FC). The estimated genotype frequencies for the all Duroc pigs were: 30.8%, 45.2%, 24.1% for AA, AB and BB genotypes, respectively. The mutant A allele was significantly associated with ADG, D90 and BF whereas no significant relationship was found with FC. The change of gene frequencies by generation was shown in both selected and culled groups. These results indicate that the MC4R polymorphism could be integrated in the present selection program to realize a marker-assisted selection for the growth traits of the Duroc population.
Keywords
Melanocortin-4 receptor (MC4R); Growth traits; Genotype frequency; Pig;
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