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http://dx.doi.org/10.5187/JAST.2005.47.2.159

Association Between MSTN Gene Polymorphism and Growth Traits in Landrace Pigs  

Cho, I.C. (National Institute of Subtropical Agriculture, R.D.A.)
Choi, Y.L. (National Institute of Subtropical Agriculture, R.D.A.)
Ko, M.S. (National Institute of Subtropical Agriculture, R.D.A.)
Kim, H.S. (Division of Applied Life Science, Gyeongsang National University)
Lee, J.G. (Division of Applied Life Science, Gyeongsang National University)
Jeon, J.T. (Division of Applied Life Science, Gyeongsang National University)
Han, Sang-Hyun (National Institute of Subtropical Agriculture, R.D.A.)
Publication Information
Journal of Animal Science and Technology / v.47, no.2, 2005 , pp. 159-166 More about this Journal
Abstract
Porcine myostatin(MS1N) gene plays a key role in the differentiation of myoblast and muscle development. Genetic polymorphism was screened by single stranded conformation polymorphism(SSCP) analysis and subsequent DNA sequencing detected a nucleotide substitution(C2150T) in exon 3 of MSIN gene. Phenotypic association of the polymorphism was tested in a Landrace population and positive effects of the allele T for lean growth traits were found in the population. Even though it is not significant, the pigs have IT and TC genotypes were heavier for the body weight at birth and at twenty weeks of age than those containing genotype. Cc. However, the allele T was significantly associated with higher eye muscle area(P < 0.05). As a result of this study, we suggested that the allele T in exon 3 of MSTN gene comes a significant effect for increasing the eye muscle area without decreasing backfat thickness. This polymorphism did not change the amino acid but Taq I -RFLP matched to SSCP band patterns in exon 3 of MSTN gene, which will be an useful molecular marker for breeding of Landrace pigs.
Keywords
Association; Genotype; Growth trait; Myostatin; SSCP;
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