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http://dx.doi.org/10.5187/JAST.2004.46.5.729

Effect of Sequence Variation in Bovine Mitochondrial DNA D-Ioop Region on ~ilk Production for Hanwoo  

Kong, H.S. (Animal Products Grading Service)
Oh, J.D. (Genomic Informatics Center Hankyong National University)
Lim, H.J. (Genomic Informatics Center Hankyong National University)
Lee, H.K. (Genomic Informatics Center Hankyong National University)
Jeon, G.J. (Genomic Informatics Center Hankyong National University)
Yoon, D.H. (Livestock Research Institute)
Jeon, G.J. (Livestock Research Institute)
Choi, J.G. (Livestock Research Institute)
Choi, Y.H. (Livestock Research Institute)
Cho, B.W. (Miryang National University)
Publication Information
Journal of Animal Science and Technology / v.46, no.5, 2004 , pp. 729-734 More about this Journal
Abstract
This study was performed to analyze the sequence variations of mtDNA D-loop and their effects on milk in Hanwoo(Korean cattle). The resulting sequences were compared with previously published sequences for other cattle breeds (GenBank JOI394). The Polymerase Chain Reaction was performed to amplify a total of 964 bp between nucleotide 15758 and 383 within D-loop region of mtDNA using specific primers. Twenty polymorphic sites by nucleotide substitution were found in mtDNA D-loop region of Hanwoo. The frequencies of positions at 8, 169, 16042, 16051, 16057, 16093, 16119, 16122, 16209, 16255 and 16302 nt with high levels of sequence polymorphism were 0.150, 0.950, 0.085, 0.138, 0.106, 0.085, 0.138, 0.212, 0.085, 0.148 and 0.180, respectively. The substitution effect at 16119(p<0.1) and 16185(p< 0.05) nt was found significant on milk production. Polymorphism of mtDNA sequence in D-Ioop region could be useful for the analysis of cytoplasmic genetic variation and associations with the other economically important traits and maternal lineage analysis in Hanwoo.
Keywords
mtDNA; D-loop region; Sequence variation; Hanwoo;
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