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http://dx.doi.org/10.5187/JAST.2003.45.6.891

Sequence and Expression Analysis of c-fos Proto-oncogene in Korean Cattle (HANWOO)  

Yu, S.L. (Division of Animal Science and Resources)
Chung, H.J. (Division of Animal Science and Resources)
Jung, K.C. (Division of Animal Science and Resources)
Lee, J.H. (Division of Animal Science and Resources)
Cho, K.W. (Department of Veterinary Medicine, Chungnam National University)
Choi, J.G. (Daekwanryong Branch, National Livestock Research Institute, R.D.A.)
Na, K.J. (Daekwanryong Branch, National Livestock Research Institute, R.D.A.)
Sang, B.C. (Division of Animal Science and Resources)
Publication Information
Journal of Animal Science and Technology / v.45, no.6, 2003 , pp. 891-900 More about this Journal
Abstract
Cellular FOS(c-fos) protein is a transcription factor that forms heterodimers mostly with c-jun family and stimulates the transcription of genes containing AP-1 regulatory elements. This c-fos expression can control growth and differentiation of various precursor cells including myoblasts. The controls by c-fos gene have been identified for affecting skeletal muscle fiber traits which are the key determinants of meat quality in pigs. As a first step for identifying the relationship between c-fos gene and meat quality traits in cattle, we fully sequenced 1,443 bp of Hanwoo c-fos mRNA and analyzed expression patterns from various organs and muscle tissues. The sequence identities of Hanwoo c-fos with that of human, pig and mouse showed 89.8%, 93.3% and 87%, respectively. Analyses of the northern blot showed high c-fos expressions were obtained in spleen and rib muscle from 7 organs and 9 different parts of muscles investigated. These results presented here can be used as a valuable marker for meat quality related traits in cattle with further verification.
Keywords
Bovine; c-fos; Sequence homology; Expression pattern; Meat quality;
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