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http://dx.doi.org/10.12749/RDB.2015.39.3.83

Effects of Selenium, Vitamin E, and Their Combination on Growth, Hematological Changes, and Biological Blood Parameters in Orchidectomized Rat Model  

Kim, Hyun (Animal Genetic Resources Research Center, National Institute of Animal Science, RDA)
Choe, Changyong (Animal Genetic Resources Research Center, National Institute of Animal Science, RDA)
Seong, Hwan-Hoo (Animal Genetic Resources Research Center, National Institute of Animal Science, RDA)
Publication Information
Reproductive and Developmental Biology / v.39, no.3, 2015 , pp. 83-88 More about this Journal
Abstract
The present study was devised to determine the effects of vitamin E and selenium (Selevit) on body weight, organ weight, hematological values and biochemical parameters in the orchidectomized (Orch) rats. Intact group (n=15) received no treatment and operation. Orch+Selevit received operation and Selevit. The body weights of each group increased, but that of the Orch＋Selevit group were significantly lower than those of all the other groups. There were significantly different decreased (p<0.001) of body weights between Orch＋Selevit group and all the other groups. Also, organ weights such as heart, liver, spleen, kidney, lung and skeletal muscle were measured. The heart and liver weights in the Orch＋Selevit group were significantly different decreased (p<0.001) in comparison with those in the Intact and Sham groups. The kidney weights in the Orch＋Selevit group were significantly different decreased (p<0.01, p<0.001) in comparison with those in all the other groups. The number of white blood cell (WBC) was significantly higher (p<0.05) in the Orch＋Selevit group than in all the other groups. The hematological values of 12 parameters were not significantly different in any of the groups. The concentrations of serum total protein, albumin and alkaline phosphatase only increased significantly (p<0.05, p<0.01) in the Orch＋Selevit group as compared to that in the Orch group. We conclude that Selevit was significantly decreased the body weight in the Orch rats. Our findings suggest that Selevit may influence the process of lipid packaging and absorption in the Orch rats.
Keywords
Rat; Vitamin E; Selenium (Selevit); Orchidectomized; Hematological values;
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