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http://dx.doi.org/10.12749/RDB.2015.39.1.1

Prostaglandin $F_2{\alpha}$ Controls Reactive Oxygen Species in Bovine Corpus Luteum  

Lee, Seunghyung (Institute of Animal Resources, Kangwon National University)
Yang, Boo-Keun (College of Animal Life Science, Kangwon National University)
Park, Choon-Keun (College of Animal Life Science, Kangwon National University)
Publication Information
Reproductive and Developmental Biology / v.39, no.1, 2015 , pp. 1-6 More about this Journal
Abstract
Luteolysis is a cyclical regression of the corpus luteum in many non-primate mammalian species. Prostaglandin $F_2{\alpha}$($PGF_2{\alpha}$) from the uterus and ovary induces functional and structural luteolysis in bovine. The action of $PGF_2{\alpha}$ is mediated by $PGF_2{\alpha}$ receptor located on the luteal steroidogenic and endothelial cell membranes. $PGF_2{\alpha}$ plays an important role in regulating nitric oxide production in endothelial cells of the bovine corpus luteum. Nitric oxide production and nitric oxide synthase activity are stimulated and induced by $PGF_2{\alpha}$ in luteal endothelial cells. Moreover, the reactive oxygen species inhibits progesterone secretion in bovine luteal cells and induces apoptosis. Thus, the interaction between $PGF_2{\alpha}$ and reactive oxygen species provides important aspects in physiology of the corpus luteum forfunctional and structural luteolysis.
Keywords
Prostaglandin $F_2{\alpha}$; Reactive oxygen species; Corpus luteum; Steroidogenic luteal cell; Endothelial cell;
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