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http://dx.doi.org/10.12749/RDB.2014.38.1.35

Expression and Function of CTNNB1 in the Development of Avian Reproductive System  

Bae, Seung-Min (Department of Biotechnology, Korea University)
Song, Gwonhwa (Department of Biotechnology, Korea University)
Publication Information
Reproductive and Developmental Biology / v.38, no.1, 2014 , pp. 35-40 More about this Journal
Abstract
Beta-catenin (CTNNB1, catenin (cadherin-associated protein), beta 1) is involved in various biological processes, including embryogenesis, tumorigenesis, angiogenesis and progression of metastasis. CTNNB1, as a multifunctional and oncogenic protein, has important roles in adhesion between Sertoli cells through an N-cadherin-dependent manner and in various cancer types through its over-activation. In addition, CTNNB1 can interact with estrogen/estrogen receptor alpha complex, which regulates the transcription of WNT (wingless-type MMTV integration site family)/CTNNB1 target genes. Recently, we investigated the functional roles and expression pattern of CTNNB1 during the morphological changes of embryonic gonads of chickens and the estrogen-dependent regulation of CTNNB1 in oviduct development and potential functions as a biomarker of CTNNB1 in human epithelial ovarian cancer using the chicken as a biological research model. Therefore, in this review, we provide a new insight of potential role of CTNNB1 in the development of the female reproductive tract during early embryogenesis and ovarian carcinogenesis of laying hen models.
Keywords
CTNNB1; Estrogen; Oviduct; Ovary; Cancer;
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