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Novel Disease Model of Chronic Neutrophilic Leukemia  

Seo, Byoung-Boo (Dept. of Animal Resources, College of Life & Environmental Science, Daegu University)
Min, Sung-Hun (Dept. of Biotechnology, College of Engineering, Daegu University)
Lee, Eun-Ji (Dept. of Obstetrics and Gynecololgy, Yeung nam University)
Ryoo, Zae-Young (School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University)
Park, Hum-Dai (Dept. of Biotechnology, College of Engineering, Daegu University)
Publication Information
Reproductive and Developmental Biology / v.35, no.4, 2011 , pp. 421-425 More about this Journal
Abstract
The experimental manipulation of protooncogenes and their gene products is a valuable research tool for the study of human neoplasia. In this study, the recently identified human cervical cancer protooncogene (HccR-2) was expressed in transgenic mice under the control of the tetracycline regulatory system. The phenotype observed was similar in many respects to human chronic neutrophilic leukemia (CNL). Thus, the HccR-2 transgenic mouse model is important not only for investigating the biological properties of the HccR-2 protooncogene in vivo, but also for analyzing the mechanisms involved in the progression of CNL.
Keywords
Human cervical cancer; Protooncogene; Transgenic mice; Chronic neutrophilic leukemia;
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1 Bohm J, Schaefer HE (2002): Chronic neutrophilic leukemia; 14 new cases of an uncommon myeloproliferative disease. J Clin Pathol 55:862-864.   DOI   ScienceOn
2 Brigid H, Rosa B, Frank C, Elizabeth L (1994): Manipulating the Mouse Embryo; A Laboratory Manual. second edition. Cold Spring Harbor Laboratory Press, New York, USA, pp 217-252.
3 Standen GR, Steers FJ, Jones L (1993): Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta. J Clin Pathol 46 (4):297-298.   DOI   ScienceOn
4 Yanagisawa K, Ohminami H, Sato M (1998): Neoplastic involvement of granulocytic lineage, not granulocytic- monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia. Am J Hematol 57 (3):221-224.   DOI   ScienceOn
5 You W, Weisbrot IM (1979): Chronic neutrophilic leukemia: Report of two cases and review of the literature. Am. J Clin Pathol 72 (2):233-242.   DOI
6 Kim JW, Lee CG, Cho YH, Kim JH, Kim SJ, Kim HK, Park TC, Song SK, Namkoong SE (1996): CUMC- 6, a new diploid human cell line derived from a squamous carcinoma of the uterine cervix. Gynecol Oncol 62:230-240.   DOI   ScienceOn
7 Zittoun R, Réa D, Ngoc LH, Ramond S (1994): Chronic neutrophilic leukemia. A study of four cases. Ann Hematol 68 (2):55-60.   DOI   ScienceOn
8 Elliott MA, Dewald GW, Tefferi A, Hanson C (2001): Chronic neutrophilic leukemia (CNL); a clinical, pathologic and cytogenetic study. Leukemia 15:35-40.   DOI   ScienceOn
9 Froberg M, Brunning R, Dorion P, Litz C, Torlakovic E (1998): Demonstration of clonality in neutrophils using FISH in a case of chronic neutrophilic leukemia. Leukemia 12:623-626.   DOI   ScienceOn
10 Jaffe ES, Harris NL, Stein H, Vardiman JW (2001): World Health Organization Classification of Tumors: Pathology and Genetics of Tumours of HaematoPoietic and Lymphoid Tissues. Lyon. IARC press, World Health Organization, USA, pp 15-44.
11 Lee JW, Park JH, Kim KS, Ryoo ZY (2003): Vasopressin- SV40 T antigen expression in transgenic mice induces brain tumor and lymphoma. Biochem Biophys Res Commun 302:785-792.   DOI   ScienceOn
12 Piliotis E, Kutas G, Lipton JH (2002): Allogenic bone marrow transplantation in the management of chronic neutrophilic leukemia. Leukemia & Lymphoma 43:2051-2054.   DOI   ScienceOn