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Development of Chronic Neutrophilic Leukemia  

Seo, Byoung-Boo (Dept. of Animal Resources, College of Life & Environmental Science, Daegu University)
Park, Hum-Dai (Dept. of Biotechnology, College of Engineering, Daegu University)
Publication Information
Reproductive and Developmental Biology / v.35, no.4, 2011 , pp. 415-420 More about this Journal
Abstract
The experimental manipulation of protooncogenes and their gene products is a valuable research tool for the study of human neoplasia. In this study, the recently identified human cervical cancer protooncogene (HccR-2) was expressed in transgenic mice under the control of the tetracycline regulatory system. Mice expressing the HccR-2 transgene showed an altered myeloid development characterized by an increased percentage of mature and band-form neutrophils in the peripheral blood, liver and spleen. This phenotype is similar to human chronic neutrophilic leukemia (CNL) in many ways, which is a rare chronic myeloproliferative disorder (CMD) that presents as a sustained leukocytosis of mature neutrophils with a few or no circulating immature granulocytes, an absence of peripheral blood monocytosis, basophilia, or eosinophilia, and an infiltration of neutrophils into the liver, spleen and kidney. Thus, the HccR-2 transgenic mouse model is imperative not only for investigating the biological properties of the HccR-2 protooncogene in vivo, but also for analyzing the mechanisms involved in the progression of CNL.
Keywords
Human cervical cancer; Protooncogene; Transgenic mice; Chronic neutrophilic leukemia;
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1 Pane F, Frigeri F, Sindona M, Luciano L, Ferrara F, Cimino R, Meloni G, saglio G, Salvatore F, Rotoli B (1996): Neutrophilic-chronic myeloid leukemia; a distinct disease with a specific molecular marker. Blood 88:2410-2414.
2 Relly JT (2002): Chronic neutrophilic leukemia; A distinct clinical entity? Br J Hematol 116:10-18.   DOI   ScienceOn
3 Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen R, Sidman C, Proetzel G, Calvin D, Annunziata N, Doetschman T (1992): Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693-699.   DOI   ScienceOn
4 Standen GR, Jasani B, Wagstaff M, Wardrop CA (1990): Chronic neutrophilic leukemia and multiple myeloma. An association with lambda light chain expression. Cancer 66:162-166.   DOI   ScienceOn
5 Standen GR, Steers FJ, Jones L (1993): Clonality of chronic neutrophilic leukaemia associated with myeloma; analysis using the X-linked probe M27 beta. J Clin Pathol 46:297-298.   DOI   ScienceOn
6 Storek J (1992): Chronic neutrophilic leukemia; case report documenting the absence of bcr-abl rearrangement. Am J Hematol 41: 304-308.
7 Tuohy EL (1920): A case of splenomegaly with polymorphonuclear neutrophil hyperleukocytosis. Am J Med Sci 160: 18-25.   DOI
8 Yanagisawa K, Ohminami H, Sato M, Takada K, Hasegawa H, Yasukawa M, Fujita S (1998): Neoplastic involvement of granulocytic lineage, not granulocytic- monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia. Am J Hematol 57:221-224.   DOI   ScienceOn
9 You W, Weisbrot IM (1979):Chronic neutrophilic leukemia; Report of two cases and review of the literature. Am J Clin Pathol 72:233-242.   DOI
10 Bennet JM, Catovsky D, Daniel M, Flandrin G, Galton D, Gralnic H, Sultan C, Cox C (1994): The chronic myeloid leukaemias: Guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia. Br J Haematol 87:746-754.   DOI   ScienceOn
11 Bohm J, Schaefer HE (2002): Chronic neutrophilic leukemia; 14 new cases of an uncommon myeloproliferative disease. J Clin Pathol 55:862-864.   DOI   ScienceOn
12 Brigid H, Rosa B, Frank C, Elizabeth L (1994): Manipulating the Mouse Embryo; A Laboratory Manual. SecondEdition. Cold Spring Harbor Laboratory Press. New York, USA pp 217-252.
13 Di Donato C, Croci G, Lazzari S, Scarduelli L, Vignoli R, Buia M, Tramaloni C, Maccari S, Plancher AC (1986): Chronic neutrophilic leukemia; description of a new case with karyotypic abnormalities. Am J Clin Pathol 85:369-371.   DOI
14 Elliott MA, Dewald GW, Tefferi A, Hanson C: Chronic neutrophilic leukemia (CNL); a clinical, pathologic and cytogenetic study. Leukemia 2001, 15:35-40.   DOI   ScienceOn
15 Fox G, Anderson C, Loew M, Quimby W (2002): Laboratory Animal Medicine. 2nd ed. Academic press. San Diego, USA pp 42-43.
16 Froberg M, Brunning R, Dorion P, Litz C, Torlakovic E (1998): Demonstration of clonality in neutrophils using FISH in a case of chronic neutrophilic leukemia. Leukemia. 12:623-626.   DOI   ScienceOn
17 Hasle H, Olesen G, Kerndrup G, Philip P, Jacobsen N (1996): Chronic neutrophil leukaemia in adolescence and young adulthood. Br J Haematol 94:628- 630.   DOI   ScienceOn
18 Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller- Hermelink, HK, Vardiman J, Lister T, Bloomfield C (1997): World Health Organisation classification of neoplastic diseases of the haematopoietic and lymphoid tissues; report of the clinical advisory committee meeting- Airlie House. J Clin Oncol 17:3835-3849.
19 Hiroaki H, Toshiya I, Takahiro S, Hideaki O, Yasuhiro E, Kohichiro T, Tatsutoshi N, Takatoshi I, Yoshio Y, Hisamaru H (1999): Expression of E2A-HLF chimeric protein induced t-cell apoptosis, b-cell maturation arrest and development of acute lymphoblastic leukemia. Blood 93:2780-2790.
20 Imbert M, Vardiman JW, Bain B: Chronic myeloproliferative diseases. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (2001): World Health Organisation Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, IARC Press, World Health Organization, USA, pp 20- 28.
21 Kojima K, Yasukawa M, Hara M, Nawa Y, Kimura Y, Narumi H, Fujita S (1999): Familial occurrence of chronic neutrophilic leukaemia. Br J Haematol 105: 428-430.   DOI   ScienceOn
22 Kwong YL, Cheng G (1993): Clonal nature of chronic neutrophilic leukemia. Blood 82:1035-1036.
23 Lee JW, Park JH, Kim KS, Ryoo ZY (2003): Vasopressin- SV40 T antigen expression in transgenic mice induces brain tumor and lymphoma. Biochem Biophys Res Commun 302:785-792.   DOI   ScienceOn
24 Matano S, Nakamura S, Kobayashi K, Yoshida T, Matsuda T, Sugimoto T (1997): Deletion of the long arm of chromosome 20 in a patient with chronic neutrophilic leukemia; cytogenetic findings in chronic neutrophilic leukemia. Am J Hematol 54: 72-75.   DOI   ScienceOn
25 Meyer S, Feremans W, Cantiniaux B, Capel P, Huygen K, Dicato M (1993): Successful alpha-2b-interferon therapy for chronic neutrophilic leukemia. Am J Hematol 43:307-309.   DOI   ScienceOn
26 Orazi A, Cattoretti G, Sozzi G (1989): A case of chronic neutrophilic leukemia with trisomy 8. Acta Haematol 81:148-151.   DOI   ScienceOn