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Studies on the Production of Transgenic Rabbits with Growth Hormone Receptor and IGF-1 Receptor Genes  

김현주 (선문대학교 응용생물과학부)
강회성 (선문대학교 응용생물과학부)
최화식 (김천대학교 임상병리학과)
임경순 (서울대학교 동물자원과학과)
진동일 (선문대학교 응용생물과학부)
Publication Information
Korean Journal of Animal Reproduction / v.27, no.1, 2003 , pp. 1-7 More about this Journal
Abstract
Transgenic rabbits were produced by DNA microinjection using growth hormone receptor (GHR) and IGF-1 receptor (IGF-1R) genes fused to metallothionein(MT) promoter. The overall efficiencies for production of transgenic rabbits were 3.2% and 3.1% for GHR and IGF-lR genes, respectively. Founder rabbits transmitted transgenes to their progenies through medelian fashion. Growth rate of GHR and IGF-lR transgenic rabbits was significantly faster than that of non-transgenic rabbits. Transgenic rabbits grew large. (25% and 15% increase in body weight of GHR and IGF-lR transgenic rabbits, respectively) than non-transgenic rabbits and organ weight of transgenic rabbits increased, suggesting that GHR and IGF-1R genes affects growth rates in transgenic rabbits.
Keywords
Transgenic rabbits; Growth hormone receptor gene; ICF-1 receptor gene; Growth rate;
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