Browse > Article
http://dx.doi.org/10.21593/kjhno/2022.38.1.43

Case Report: Intracapsular Carcinoma Ex Pleomorphic Adenoma of Parotid Gland  

Lee, Seungyeol (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
Son, Hwangkyu (Department of Pathology, College of Medicine, Hanyang University)
Park, Ho Sub (Department of Pathology, College of Medicine, Hanyang University)
Song, Chang Myeon (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
Publication Information
Korean Journal of Head & Neck Oncology / v.38, no.1, 2022 , pp. 43-47 More about this Journal
Abstract
Among a variety of malignant types for parotid gland tumors, intracapsular carcinoma ex pleomorphic adenoma which is classified as a non-invasive tumor has been reported rarely. We report a case of a 69-years old patient, who presented with a left parotid mass that was detected 30 years ago. Fine needle aspiration biopsy result of the mass was "suggestive of pleomorphic adenoma". Superficial partial parotidectomy was performed for the mass and the permanent pathologic finding was "intracapsular carcinoma ex pleomorphic adenoma" which was a salivary ductal carcinoma with well-preserved myoepithelial cells surrounding the malignant epithelial cell clusters. Surgical resection is the main treatment modality for the treatment of intracapsular carcinoma ex pleomorphic adenoma. Herein, we present the case with a review of literature.
Keywords
Pleomorphic adenoma; Intracapsular carcinoma ex pleomorphic adenoma;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: Pathologic analysis of 73 cases. Hum Pathol. 2001;32:596-604.   DOI
2 LiVolsi VA, Perzin KH. Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: A clinicopathologic study. Cancer. 1977;39:2209-2230.   DOI
3 Gnepp DR. Malignant mixed tumors of the salivary glands: A review. Pathol Annu. 1993;28:279-288.
4 Rajexh L, Himan A, Don P, Henrik H. Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features. Eur Arch Otorhinolaryngol, 2008;265:1563-1566.   DOI
5 Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L. Major and minor salivary gland tumors. Crit Rev Oncol Hematol. 2010;74:134-148.   DOI
6 Joyce A, Vinod G, Robert AS, Alfred KY. Carcinoma ex pleomorphic adenoma: A comprehensive review of clinical, pathological and molecular data. Head and Neck pathol. 2012;6:1-9.
7 Witt RL. The significance of the margin in parotid surgery for pleomorphic adenoma. Laryngoscope. 2002;112:2141-2154.   DOI
8 Brandwein M, Huvos AG, Dardick I, Thomas MJ, These ND. Noninvasive and minimally invasive carcinoma ex mixed tumor: A clinicopathologic and ploidy study of 12 patients with major salivary tumors of low(or no) malignant potential. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81:655-664.   DOI
9 Batsakis JG. Metastatic patterns of salivary gland neoplasm. Ann Otol Rhinol Laryngol. 1982;91:465-466.   DOI
10 Kong M, Drill EN, Morris L, West L, Klimstra D, Gonen M, et al. Prognostic factors in myoepithelial carcinoma of salivary glands: A clinicopathologic study of 48 cases. Am J Surg Pathol. 2015;39:931-938.   DOI
11 Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP. Salivary gland pleomorphic adenoma. Am J Clin Oncol. 2008;31:95-99.   DOI
12 Di PS. Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. Head Neck Pathol. 2013;7:S68-S76.
13 Barnes L, Eveson JW, Reichart P, Sidransky D. World health organisation classification of tumours. 4th ed. Lyon: IARC Press; 2017.
14 Felix A, Rosa SJ, Mendonca ME, Torrinha F, Soares J. Intracapsular carcinoma ex pleomorphic adenoma: Report of a case with unusual metastatic behavior. Oral Oncol. 2002;38:107-110.   DOI
15 Spiro RH. Salivary neoplasms: Overview of a 35-year experience with 2,807 patients. Head Neck Surg. 1986;8:177-184.   DOI
16 Weiler C, Zengel P, Vanderwal JE, Guntinas-Lichius O, Schwarz S, Harrison JD, et al. Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: A clinicopathological investigation of 41 cases. Histopathology. 2011;59:741-750.   DOI