Browse > Article
http://dx.doi.org/10.21593/kjhno/2020.36.1.39

A Treatment of Basal cell Carcinoma on the Face of a Xeroderma Pigmentosum Patient: A Case Report  

Bae, Jaehyun (Department of Plastic and Reconstructive Surgery, Konkuk University Medical Center)
Jun, Dongkeun (Department of Plastic and Reconstructive Surgery, Konkuk University Medical Center)
Kim, Jeenam (Department of Plastic and Reconstructive Surgery, Konkuk University Medical Center)
Lee, Myungchul (Department of Plastic and Reconstructive Surgery, Konkuk University Medical Center)
Shin, Donghyeok (Department of Plastic and Reconstructive Surgery, Konkuk University Medical Center)
Lim, So Dug (Department of Pathology, Konkuk University Medical Center)
Choi, Hyungon (Department of Plastic and Reconstructive Surgery, Konkuk University Medical Center)
Publication Information
Korean Journal of Head & Neck Oncology / v.36, no.1, 2020 , pp. 39-44 More about this Journal
Abstract
Xeroderma pigmentosum is a rare autosomal recessive disease, related to defects in DNA repair mechanism. It presents skin lesions on sun-exposed areas, leading to various skin cancer. Skin lesions can be treated with cryotherapy, skin resurfacing, 5-FU, Imiquimod, topical T4 endonuclease V, radiotherapy and genetic therapy, but invasive skin cancer should be treated by a surgery. We report a 12-year-old female xeroderma pigmentosum patient with recurrent basal cell carcinoma successfully treated by skin grafting. In that there is no cure for this disease, prevention and patient education is most important.
Keywords
Skin neoplasm; Xeroderma pigmentosum; Skin transplantation;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Lehmann J, Seebode C, Martens MC, Emmert S. Xeroderma Pigmentosum - Facts and Perspectives. Anticancer Res. 2018;38:1159-1164.
2 Friedberg E. The discovery that xeroderma pigmentosum (XP) results from defective nucleotide excision repair. DNA Repair. 2004;3:183-195.   DOI
3 Black JO. Xeroderma Pigmentosum. Head Neck Pathol. 2016;10:139-144.   DOI
4 Lehmann AR, McGibbon D, Stefanini M. Xeroderma pigmentosum. Orphanet journal of rare diseases. 2011;6:70.   DOI
5 Lee JS, Kang HY, Lee ES, Kim YC. Two Cases o f Xeroderma Pigmentosum with Skin Cancer. Korean J Dermatol. 2005;43:233.
6 Bradford PT, Goldstein AM, Tamura D, Khan SG, Ueda T, Boyle J, et al. Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair. Journal of medical genetics. 2011;48:168-176.   DOI
7 Kumar J. De Sanctis-Cacchione Syndrome. Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2020.
8 Mahindra P, DiGiovanna JJ, Tamura D, Brahim JS, Hornyak TJ, Stern JB, et al. Skin cancers, blindness, and anterior tongue mass in African brothers. Journal of the American Academy of Dermatology. 2008;59:881-886.   DOI
9 Shah JP, Patel SG. American Cancer Society Atlas of Clinical Oncology, Cancer of the Head and Neck. BC Decker Inc, Hamilton, London. 2001:1:77-99.
10 Chidzonga MM, Mahomva L, Makunike-Mutasa R, Masanganise R. Xeroderma pigmentosum: a retrospective case series in Zimbabwe. Journal of oral and maxillofacial surgery. 2009;67:22-31.
11 Adam M, Ardinger H, Pagon R, Wallace S, Bean L, Stephens K, et al. Xeroderma Pigmentosum. GeneReviews. 2016.
12 Bradford PT, Goldstein AM, Tamura D, Khan SG, Ueda T, Boyle J, et al. Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair. J Med Genet. 2011;48:168-176.   DOI
13 Kraemer KH, Lee M-M, Andrews AD, Lambert WC. The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer: the xeroderma pigmentosum paradigm. Archives of dermatology. 1994;130:1018-1021.   DOI
14 Sibar S, Findikcioglu K, Erdal AI, Barut I, Ozmen S. Technical Aspects and Difficulties in the Management of Head and Neck Cutaneous Malignancies in Xeroderma Pigmentosum. Arch Plast Surg. 2016;43:344-351.   DOI
15 Ghartimagar D, Ghosh A, Shrestha SR, Shrestha S, Thapa S, Narasimhan R, et al. Basal Cell Carcinoma in Cases with or without Xeroderma Pigmentosum. Journal of the Nepal Medical Association. 2017;56:432-437.   DOI
16 Lehmann J, Schubert S, Emmert S. Xeroderma pigmentosum: diagnostic procedures, interdisciplinary patient care, and novel therapeutic approaches. J Dtsch Dermatol Ges. 2014;12:867-872.
17 Ozmen S, Uygur S, Eryilmaz T, Ak B. Facial resurfacing with a monoblock full-thickness skin graft after multiple malignant melanomas excision in xeroderma pigmentosum. J Craniofac Surg. 2012;23:1542-1543.   DOI
18 Roseeuw D. The treatment of basal skin carcinomas in two sisters with xeroderma pigmentosum. Clinical and experimental dermatology. 2003;28:30-32.   DOI
19 Cafardi JA, Elmets CA. T4 endonuclease V: review and application to dermatology. Expert opinion on biological therapy. 2008;8:829-838.   DOI
20 Fife D, Laitinen MA, Myers DJ, Landsteiner PB. Vismodegib Therapy for Basal Cell Carcinoma in an 8-Year-Old Chinese Boy with Xeroderma Pigmentosum. Pediatr Dermatol. 2017;34:163-165.   DOI
21 Lasso JM, Yordanov YP, Pinilla C, Shef A. Invasive basal cell carcinoma in a xeroderma pigmentosum patient: facing secondary and tertiary aggressive recurrences. Journal of Craniofacial Surgery. 2014;25:e336-e338.   DOI
22 Son WI, Byeon JH. A Patient with Xeroderma Pigmentosum Developing Radioresistant Basal Cell Epithelioma. J Korean Soc Plast Reconstr Surg. 2003;30:101.