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http://dx.doi.org/10.21593/kjhno/2019.35.2.45

A Case of Large Cell Neuroendocrine Carcinoma of the Maxillary Sinus  

Lee, Yun Jae (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine)
Jeong, Jin Hyeok (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine)
Oh, Young Ha (Department of pathology, Hanyang University College of Medicine)
Ji, Yong Bae (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine)
Publication Information
Korean Journal of Head & Neck Oncology / v.35, no.2, 2019 , pp. 45-49 More about this Journal
Abstract
Large cell neuroendocrine carcinoma is a rare epithelial neuroendocrine malignancy and is preferentially located in gastrointestinal tract and pancreas. Cases of large cell neuroendocrine carcinoma have been reported in many other locations, including the thymus, gallbladder, prostate, larynx, salivary glands, nasopharynx, tonsil and mastoid. However, primary sinonasal large cell neuroendocrine carcinoma never have been reported in Korea. We experienced a case of primary large cell neuroendocrine carcinoma arising from left maxillary sinus recently. A 82-year-old male patient presented with nasal obstruction and epistaxis. The biopsy revealed large cell neuroendocrine carcinoma with poor differentiation. After a general evaluation, the patient was staged as cT3N0M0. The patient was treated by combined radiotherapy and chemotherapy. We report this rare case with literature review.
Keywords
Large cell neuroendocrine carcinoma; Paranasal sinus;
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