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A Case of Malignant Triton Tumor on Supraclavicular Area  

Lim, Sang Ho (Department of Otolaryngology Head & Neck Surgery, School of Medicine, Chonbuk National University)
Park, Hee Tack (Department of Otolaryngology Head & Neck Surgery, School of Medicine, Chonbuk National University)
Hong, Ki Hwan (Department of Otolaryngology Head & Neck Surgery, School of Medicine, Chonbuk National University)
Publication Information
Korean Journal of Head & Neck Oncology / v.29, no.2, 2013 , pp. 54-57 More about this Journal
Abstract
Malignant triton tumor(MTT) is a rare type of malignant peripheral nerve sheath tumor(MPNST) with focal rhabdomyoblastic differentiation. MTT constitutes about 5% of all MPNSTs and described the first case of a MTT in a patient with Von Recklinghausen disease by Masson in 1932. MTT is commonly seen in the head, neck, extremities and trunk. It can occur in sporadic form or over a setting of neurofibromatosis-1(NF-1). The diagnosis can be confirmed based on morphologic grounds supported by an immunostain such as S-100 protein. Desmin, myo-D1 and myogenin are immunostains positive for rhabdomyoblasts. MTT has an aggressive biological behavior so prognosis of this rare and highly malignant tumor is poor and optimal treatment remains unclear. But modern treatment consisted of radical excision and postoperative radiotherapy has improved the prognosis of such cases.
Keywords
Malignant peripheral nerve sheath tumor(MPNST); Malignant triton tumor; Rhabdomyoblast;
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1 Mason P, Martin JF. Rhabdomyomes des nerfs. Bull Assoc Fr Cancer. 1938;27:751-767.
2 Kim JR, Gi JJ, Ham EK. Pathophysiology of malignant Triton tumors. Korean J Pathophysiol. 1982;16:52-59.
3 Dewit L, Albus-Lutter CE, De Jong AS, Voute PA. Malignant schwannoma with a rhabdomyoblastic component, a so-called triton tumor: A clinicopathologic study. Cancer. 1986;58:1350-1356.   DOI
4 Brooks JS, Freeman M, Enterline HT. Malignant "Triton" tumors: Natural history & immunohistochemistry of nine new cases with literature review. Cancer. 1985;55:2543-2549.   DOI
5 Han DH, Kim DG, Chi JG, Park SH, Jung HW, Kim YG. Malignant triton tumor of the acoustic nerve. Case report. J Neurosurg. 1992;76:874-877.   DOI
6 Kim ST, Kim CW, Han GC, Park C, Jang IH, Cha HE, et al. Malignant triton tumor of the nasal cavity. Head Neck. 2001;23:1075-1078.   DOI
7 Woodruff JM, Chernik NL, Smith MC, Millett WB, Foote FW. Peripheral nerve tumors with rhabdomyosarcomatous differentiation(malignant "Triton" tumors). Cancer. 1973;32:426-439.   DOI
8 Terzic A, Bode B, Gratz KW, Stoeckli SJ. Prognostic factors for the malignant triton tumor of the head and neck; Head & Neck. 2009;31(5):679-688.   DOI
9 Masson P. Recklinghausen's neurofibromatosis, sensory neuromas and motoric neuromas. Libman Anniversary. Vol 2 NY: International Press; 1932. p.793-802.
10 Enzinger FM, Weiss SW. Soft tissue tumors. 2nd ed. Elsevier Health Press; 1988. p.781-806.
11 Matsunou H, Shimoda T, Kakinoto S, Yamashita H, Ishikawa E, Mukai M. Histopathologic and immunohistochemical study of malignant tumors of peripheral nerve sheath(Malignant schwannoma). Cancer. 1985;56:2269-2279.   DOI
12 Nakajima T, Watanabe S, Sato Y, Shimosato Y, Motoi M, Lennert K. S-100 protein in Langerhans cells, interdigitating reticulum cells and histiocytosis X cells. Gann. 1982;73:429-443.
13 Shamir B, Fiona G. Malignat triton tumor of the head and neck: A case study. Otolaryngol Head Neck Surg. 1990;Nov.10:738-42.
14 Miettinen M. Diagnostic soft tissue pathology. Churchill Livingstone. 2003:367-378.