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Utility of FDG PET/CT Scans on Extracapsular Spread of Squamous Cell Carcinoma in the Larynx  

Joo, Young-Hoon (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
Yoo, Ie-Ryung (Department of Nuclear Medicine, College of Medicine, The Catholic University of Korea)
Cho, Kwang-Jae (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
Song, Jee-Nam (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
Yoo, Dong-Joon (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
Lee, Ho-Suk (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
Kim, Min-Sik (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
Publication Information
Korean Journal of Head & Neck Oncology / v.28, no.2, 2012 , pp. 118-121 More about this Journal
Abstract
Backgrounds : To evaluated the use of FDG PET/CT for the identification of extracapsular spread(ECS) with histologic correlation in laryngeal cancer. Methods : We reviewed 79 medical records of patients who underwent of FDG PET/CT for laryngeal cancer before surgery. Results : ECS was present in 41.9%(18/43) dissected necks and in 34.5%(20/58) dissected cervical levels. There was a significant difference in the SUVmax between cervical lymph nodes with ECS and without ECS($6.39{\pm}4.53$ vs. $1.19{\pm}1.64$, p<0.001). The cut-off value for the SUVmax for differentiating with ECS from without ECS was 2.8 with the sensitivity of 85.7% and the specificity of 85.6%. Conclusion : The median SUVmax cut-off values of FDG PET/CT higher than 2.8 was associated with greater risk cervical lymph node metastasis with ECS in patients with laryngeal cancer.
Keywords
Squamous cell carcinoma; Larynx; Lymphatic metastasis; Positron-emission tomography;
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