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Treatment Outcome after Induction Chemotherapy Followed by Radiation Therap in Locally Advanced Hypopharyngeal Cancer  

Song, Si-Yeol (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim, Sung-Bae (Departments of Medical Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim, Sang-Yoon (Departments of Otorhinolaryngology, Asan Medical Center, College of Medicine, University of Ulsan)
Nam, Soon-Yuhl (Departments of Otorhinolaryngology, Asan Medical Center, College of Medicine, University of Ulsan)
Choi, Eun-Kyung (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim, Jong-Hoon (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Ahn, Seung-Do (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Je, Hyoung-Uk (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Lee, Sang-Wook (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Publication Information
Korean Journal of Head & Neck Oncology / v.24, no.2, 2008 , pp. 162-168 More about this Journal
Abstract
Purpose：To know the results after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer Methods and Materials：From August 1990 to December 2003, forty patients who were treated with induction chemotherapy and curative radiation therapy were analyzed retrospectively. Median age of patients was 60 years(range：40-78 years) and clinical stage was wholly stage 3 or 4. Induction chemotherapy used cisplatin with 5-FU or docetaxel, and its interval was 3 weeks. Irradiated radiation dose was 70 to 78Gy (median：70.8Gy). Results：Median follow-up time was 39.4 months(range：8-115 months). Treatment failures were observed in 52.5% patients, and main failure pattern was local recurrence in 16 patients. 3 and 5 year disease free survival were 52.6%, 48.2% respectively and values of overall survival were 60.0, 43.9% and median survival time was 44.7 months. Treatment response was only a prognostic factor for survival. Laryngeal preservation was observed in twenty-four(60.0%) patients. Conclusion：Initial primary tumor stage was a significant prognostic factor for laryngeal preservation, and response after radiation therapy was a prognostic factor for long-term survival after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer.
Keywords
Hypopharyngeal cancer; Induction chemotherapy; Radiation therapy; Larynx preservation;
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