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VEGF Expression and Microvessel Density in Salivary Gland Tumor  

Park Chul-Won (Department of Otolaryngology, College of Medicine, Hanyang University)
Kim Su-Young (Department of Otolaryngology, College of Medicine, Hanyang University)
Kim Kyung-Rae (Department of Otolaryngology, College of Medicine, Hanyang University)
Lee Hyung-Seok (Department of Otolaryngology, College of Medicine, Hanyang University)
Paik Seung-Sam (Department of Pathology, College of Medicine, Hanyang University)
Park Yong-Wook (Department of Pathology, College of Medicine, Hanyang University)
Tae Kyung (Department of Otolaryngology, College of Medicine, Hanyang University)
Publication Information
Korean Journal of Head & Neck Oncology / v.21, no.2, 2005 , pp. 183-189 More about this Journal
Abstract
Objectives: Angiogenesis is the process of new blood vessel development from preexisting vessel. The growth of tumor is dependent on angiogenesis. This study was aimed to determine the role of the VEGF expression and MVD(microvessel density) in salivary gland tumors and to analyze the correlation between the expression of VEGF/MVD, and clinical manifestation. Material and Methods: We analyzed the expression of VEGF and average MVD and neo-MVD in the 57 cases of salivary gland tumors by immunohistochemistry. Results: VEGF expression was higher in malignant tumors than in benign tumors. Average and neo-MVD were not different in benign tumor and malignant tumor. There was a tendency of positive correlation between VEGF expression and MVD but it was not statistically significant. Stage, T stage and recurrance rate were not correlated with VEGF expression, average-MVD and neo-MVD. Expression of VEGF, average-MVD and neo-MVD were significantly increased in Warthin's tumor compared with pleomorphic adenoma. Conclusion: Overexpression of VEGF has an important role in malignant salivary gland tumors.
Keywords
Salivary gland neoplasms; VEGF; CD34; Ki67;
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