Browse > Article

A Review of Minor Salivary Gland Tumor  

Tae Kyung (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
Ji Yong-Bae (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
Jin Bong-Jun (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
Lee Seung-Hwan (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
Lee Hyung-Seok (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
Publication Information
Korean Journal of Head & Neck Oncology / v.21, no.2, 2005 , pp. 115-120 More about this Journal
Abstract
Background and Objectives: Minor salivary gland tumors vary in their primary sites, histopathology and biological behavior. Therefore, various factors are considered in selecting the treatment modality and predicting the prognosis. We performed this study for the purpose of getting further understanding and more supporting ideas for the diagnosis and treatment of minor salivary gland tumor. Materials and Methods: A retrospective analysis of the patients with 52 cases of minor salivary gland tumor who were treated at the Hanyang University Hospital from 1996 to 2003 was performed. We analyzed demography, symptoms, histopathology, treatment and outcomes by the review of medical records. Results: Among 52 cases of minor salivary gland tumor, 46% were classified as benign and 54% were classified as malignant tumors. The most common benign tumor was pleomorphic adenoma. Adenoid cystic carcinoma(15/28) was the most common in malignant tumors. Eight patients were males and sixteen patients were females in benign tumors and 10 patients were males and 18 patients were females in malignant tumors. The most common site of benign tumor was the palate(17/22), whereas malignant tumors were most common in the nasal cavity and paranasal sinus(9/28). Asymptomatic mass was the most common symptom. According to the criteria given by the AJCC on staging, stage III and IV(21/28) were more common than stage I and 11(7/28). All benign tumors were treated with simple excision and had no recurrence. In malignant tumors, 25 patients underwent radical excisional operation and 13 patients of them had postoperative radiation therapy. Three of them were treated with additional chemotherapy. In whom treated with radical operation, 9 patients had recurrence. Three were recurred at the primary site with neck node metastasis, 3 were recurred at the primary site with lung metastasis, 1 was recurred at the primary site with neck node and lung metastasis, 1 was recurred only at neck node. Conclusion: In minor salivary gland tumor, malignant was more common than benign. Malignant tumor originated from minor salivary gland were more frequently diagnosed at advanced stage with high recurrence rate and distant metastasis. Early detection of the disease is needed to improve the prognosis of the patients with malignant tumors of the minor salivary glands.
Keywords
Minor salivary gland; Salivary gland tumor;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Gnepp DR, Brandwein MS, Henley JD: Salivary and lacrimal glands. In: Gnepp DR. Diagnostic surgical pathology of the head and neck. 1st ed. Philadelphia, Pennsylvania: Saunders, 2001:325-430
2 Park YY, Shim YS, Oh KK, Lee YS, Park SJ, Kwon SW: A clinical analysis in minor salivary gland tumor. Korean J Otolaryngol. 1998;41:929-934
3 David WE, Lawrence RK: Management of malignant salivary gland tumors. In: Harrison LB, Sessions RB, Hong WK., editors. Head and neck cancer. 2nd Ed. Philadelphia: Lippincott Willians & Wilkins, 2004:620-651
4 Regis de Brito Santos I, Kowalski LP, Cavalcante de Araujo V: Multivariate analysis of risk factors for neck metastases in surgically treated parotid carcinomas. Arch Otolaryngol Head Neck Surg.2001;127:56-60   DOI
5 Spiro RH, Thaler HT, Hicks WF, Kher UA, Huvos AH, Strong EW: The importance of clinical staging of minor salivary gland carcinoma. Am J Surg. 1991;162:330-336   DOI   ScienceOn
6 Lee CS, Choi JO, Lee SH, Jung KY, Lee NJ: A clinical analysis of minor salivary gland tumors. Korean J Head Neck Oncol. 1994; 10:25-30
7 Bradley PJ: Submandibular gland and minor salivary gland neoplasms. Curr Opin Otolaryngol Head Neck Surg. 1999;7:72-78   DOI   ScienceOn
8 Strick MJ, Kelly C, Soames JV, McLean NR: Malignant tumours of the minor salivary glands-a 20 year review. Br J Plast Surg. 2004;57:624-31   DOI   ScienceOn
9 Lopes MA, Santos GC, Kowalski LP: Multivariate survical analysis of 128 cases of oral cavity minor salivary gland carcinomas. Head and Neck. 1998;20:699-706   DOI   ScienceOn
10 Martin VTW, Salmaso R, Onnnis GL: Tumors of salivary glands. Review if 479 cases with particular reference to histologic types, site, age and sex distribution. Appl Pathol. 1989;7:154-160
11 Waldron CA, El-Mofty SK, Gneep DR: Tumors of intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Pathol. 1988;66:323-333   DOI   ScienceOn
12 Matsuba HM, Thawley SE, Simpson JR: Adenoid cystic carcinoma of major and minor salivary gland origin. Laryngoscope. 1984;94:1316-1318
13 Everson JW, Cawson RA: Tumors of the minor (oropharyngeal) salivary glands: a demographic study of 366 cases. J Oral Pathol. 1985;14:500-509   DOI
14 Anderson LJ, Therkildsen MH, Ockelmann HH, Bentzen JD, Schiodt T, Hansen HS: Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland Prognostic factors and treatment results. Cancer. 1991; 682:431-437
15 Shah JP, Ihde JK: Salivary gland tumors. Cunr Probl Surg. 1990;27:775-883   DOI   ScienceOn
16 Wal JE van der, Snow GB, Waal I van der: Histological reclassification of 101 intraoral salivary gland tumors (new WHO classification). J Clin Pathol. 1992;45:834-835   DOI   PUBMED
17 Johnson PA, Millar BG, Leopard PJ: Intraosseous adenoid cysic carcinoma of mandible. Br J Oral Maxillofac Surg. 1989;27: 501-505   DOI   ScienceOn
18 Nagler RM, Laufer D: Tumor of the major and minor salivary glands: review of 25 years of experience. Anticancer Res. 1997; 17:701-707