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Evaluation of the Response of Radiotherapy to Squamous Cell Carcinoma of the Head and Neck using $^{18}FDG-PET$  

Lee Sang-Wook (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Ryu Jin-Sook (Departments of Neclear Medicine, Asan Medical Center, College of Medicine, University of Ulsan)
Yi Byong-Yong (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim Jong-Hoon (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Ahn Seung-Do (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Shin Seong-Soo (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim Sang-Yoon (Departments of Otorhinolaryngolog, Asan Medical Center, College of Medicine, University of Ulsan)
Nam Soon-Yuhl (Departments of Otorhinolaryngolog, Asan Medical Center, College of Medicine, University of Ulsan)
Song Si-Yeol (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Yoon Sang-Min (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Park Jin-Hong (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
Kim Sung-Bae (Departments of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan)
Kim Jae-Seung (Departments of Neclear Medicine, Asan Medical Center, College of Medicine, University of Ulsan)
Publication Information
Korean Journal of Head & Neck Oncology / v.19, no.1, 2003 , pp. 58-62 More about this Journal
Abstract
Purpose: To evaluate the efficacy of positron emission tomography with 2-[F-18] fluoro-2-deoxy-D-glucose in discrimination of response in the nasopharyngeal carcinoma patients who treated with radiotherapy. Methods and Materials: Twenty-four patients who underwent FDG-PET scan before and after radiotherapy for no disseminated head and neck carcinoma at the Asan Medical Center between August 2001 and September 2002 were evaluate by prospective analysis. First FDG-PET scan performed before radiotherapy within 1 month, and second FDG-PET scan performed 1 month after radiotherapy. FDG-PET images were analyzed by standard uptake value (SUV). Follow-up period was more than 6 months. Results: The pretreatment SUV was 3.4-14.0 (median: 6.0) and posttreatment SUV was ground level-7.7 (median: 2.0). The overall sensitivity and specicity of FDG-PET to evaluate residual tumors in the nasopharyngeal carcinoma patients were 94% and 94%. Conclusion: FDG-PET is effective in evaluation of radiation response in the nasopharyngeal carcinoma. We think that the timing of one month after finished radiotherapy FDG-PET scan was not too fast to evaluation of radiation response.
Keywords
FDG-PET; Radiotherapy; Head and Neck; Squamous cell carcinoma;
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