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A Retrospective Analysis of Treatment-Related Prognostic Factors for Local Recurrence after Primary Radiation Therapy for Patients with Primary T1N0 Glottic Cancer  

Kim Su-Ssan (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
Kim Sang-Yoon (Departments of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center)
Nam Soon-Yuhl (Departments of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center)
Choi Seung-Ho (Departments of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center)
Cho Kyung-Ja (Departments of Pathology, University of Ulsan, College of Medicine, Asan Medical Center)
Kim Jong-Hoon (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
Ahn Seung-Do (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
Shin Seong-Soo (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
Song Si-Yeol (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
Choi Eun-Kyung (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
Lee Sang-Wook (Departments of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
Publication Information
Korean Journal of Head & Neck Oncology / v.19, no.1, 2003 , pp. 34-40 More about this Journal
Abstract
Objective: To analyze the treatment-related parameters after the radiotherapy of T1N0 squamous cell carcinoma of the glottic larynx. Materials and Methods: Between October 1989 and August 2000, 54 patients with histologically proven T1N0 squamous cell carcinoma of the glottic larynx who received definitive radiation therapy in Department of Radiation Oncology, Asan Medical Center were analyzed. They were all males with age ranged from 31 to 80 years (median 61 years). 1997 AJCC stages were 31 T1a, 23 T1b. Patients were treated with 4-MV X-rays with a parallel-opposed two-field technique. Ten patients received 66.0-68.4Gy at 1.2Gy per fraction twice daily, 21 patients received 64.8-66.6Gy at 1.8Gy per fraction once daily, and 23 patients received 66.0Gy at 2.0Gy per fraction once daily. Follow-up period was 16-119 months (median 56 months). Results: 5-year overall survival and local control rates for patients with T1 lesions were 87.0% and 88.5%, respectively. 5-year local control with larynx preservation rate was 90.5%. Host and tumor-related prognostic factors including age, stage, anterior commissure involvement and tumor bulk proved not to be significant. Only shorter overall treatment time among treatment-related factors had correlation with imporved local control. Conclusion: Comparable high local control rate with organ preservation was achieved with primary radiation therapy and salvage surgery. Shortening of overall treatment time is related to improved local control rate. To determine the optimal fractionation scheme, randomized trial is mandatory.
Keywords
Early glottic cancer; Radiation therapy; Prognostic factor;
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Times Cited By KSCI : 1  (Citation Analysis)
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