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Concomitant Chemoradiotherapy as Primary Therapy for Advanced Head and Neck Cancer  

Lee Joo-Yun (Department of Otolaryngology, College of Medicine Chungbuk National University)
Lee Dong-Wook (Department of Otolaryngology, College of Medicine Chungbuk National University)
Choi Young-Seok (Department of Otolaryngology, College of Medicine Chungbuk National University)
Jin Hong-Ryul (Department of Otolaryngology, College of Medicine Chungbuk National University)
Lee Hyun-Seok (Department of Otolaryngology, College of Medicine Chungbuk National University)
Yeon Je-Yeob (Department of Otolaryngology, College of Medicine Chungbuk National University)
Shin See-Ok (Department of Otolaryngology, College of Medicine Chungbuk National University)
Publication Information
Korean Journal of Head & Neck Oncology / v.18, no.2, 2002 , pp. 163-167 More about this Journal
Abstract
Background: To achieve the efficacy and toxic effects of concomitant FP chemoradiotherapy regimen by means of response and survival in patients with advanced head and neck cancer. Patient and Method: Thirty-three previously untreated patients with newly diagnosed advanced head and neck cancer were retrospectively reviewed. Results: Thirty-one patients were evaluable for the tumor response. Total response rate was 93%(complete response 60%, partial response 33%). Disease free survival was 37 month and 3-year overall survival was 63%. Grade 3 or 4 stomatitis was observed in 83% and appeared as the dose limiting toxicity for this regimen. Conclusion: Concomitant chemoradiotherapy with cisplastin and 5-fluorouracil is effective as primary therapy for advanced head and neck cancer. The majority of patients experienced severe stomatitis. Identification of less toxic regiment and improved disease control emerge as important future research goals.
Keywords
Chemoradiotherapy; Advanced head and neck cancer;
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1 Lefebvre JL, Chevalier D, Luboinski B. Kirkpatrick A, Collette L, Sahmoud T : Larynx preservation in pyriform sinus cancer : preliminary results of a European organization for reserch and treatment of cancer phase III trial. JU of Natl Cancer inst. 1996 ; 88: 890-899   DOI   ScienceOn
2 Begg AC, Van der Kolk PJ, Dewit L, Bartelink H : Radiosensitization by cisplatin of RIF1 tumour in vitro. Int J radiat Biol Relat Stud Phys Chem Med 1986 ; 50 (5) : 871-884   DOI   PUBMED
3 Pignon JP, Bourhis J, Domenge C, Designe L : Chemotherapy as an adjunct to definitive locoregional treatment for head and neck squamous cell carcinoma ; result of three meta-analysis using updated individual data. Lancet 2000 ; 14 : 838-844
4 Lavertu, Pierre, adelstein, David J, et al : Aggressive concurrent chemoradiothrapy for squamous cell head and neck cancer : An 8-year single-institution experience. Arch Otolaryngol Head Nck Surg. 1999 ; 125 (2) : 142-148   DOI
5 Schaake-Koning C, Gogaet W, Dalesio O, et al : Effect of con-comittant cisplatin and radiotherpy on inoperable non-small cell lung cancer. N eng J Med 1992 ; 326 : 524-530   DOI   ScienceOn
6 Adelstein DJ, Saxton JP, Lavertu P, et al : A phase II randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer : preliminary results. Head and Neck. 1997 ; 19 : 567-575   DOI   ScienceOn
7 Tavorath R, Pfister DG : Chemotherapy for recurrent disease and combined modality therapies for head and neck cancer. Curr Opin Oncol. 1995 ; 7 : 242-247   DOI   ScienceOn
8 Asegawa Y, Matssura H, Kano M, Shimozato K : A randomized trial of neoadjuvant chemotherapy with cisplatin and 5-FU in advanced head andneck cancer. Proc Am Soc Cli Oncol. 1994 ; 13 : 286
9 Koness RJ, Glicksman A, Liu L, et al : Recurrence patterns with concurrent platinum- based chemothrapy and accelerated hyper-fractionated radiotherapy in stage III and IV head and neck cancer patients. Am J Surg. 1997 ; 174 : 532-535   DOI   ScienceOn
10 Vokes EE, Pajak TF : Enhancing the therapeutic index of concomitant chemoradiotherapy for Head and Neck cancer: Ann Oncol. 1998 ; 9 : 471-474
11 Department of Veterans Affairs Laryngeal Study Group. Induction chemotherapy plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991 ; 324 : 1685-1690   DOI   ScienceOn
12 Shah JP, Ladd W : Treatment of cancer of the head and neck cancer : the role of chemotherapy. Crit Rev Oncol Hematol. 1996 ; 24 : 97-116   DOI   ScienceOn
13 Lawrence TS, Davis MA, Maybaum J : Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects. Int J Radiat Oncol Biol Phys. 1994 ; 29 (3) : 519-523   DOI   PUBMED   ScienceOn
14 Calais G, Alfonsi M, Bardet E, et al : Randomized study compairing radiation alone (RT) versus RT with concomitant chemotherapy (CT) in stage III and IV oropharynx carcinoma (ARCORO) : preliminary results of the 94.01 study from the French Group of Radiation Oncology for Head and Neck cancer (GORTC). Proc Am Soc Clin Oncol. 1998 ; 17 : 385a (abstr 1484)
15 Head and Neck Contracts Program: Adjuvant chemotherapy for advanced head and neck squamous cell carcinoma. Cancer. 1987 ; 60 : 301-311   DOI   PUBMED   ScienceOn
16 AI-sarraf M, LeBlanc M, Giri PGS, et al : Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer : Phase III randomized intergroup 0099. J Clin Oncol. 1998 ; 16 : 1310-1317   DOI
17 Adelstein DJ, Tan EH, Lavertu P : Treatment cancer of head and neck cancer. Cancer J Clin. 1995 ; 45 : 352-368   DOI   ScienceOn
18 Lavertu, Pierre, Adelstein, et al : Aggressive Concurrent Chemoradiotherapy for Squamous Cell Head and Neck Cancer : An 8-year single-institution experience, Arch Otlaryngol Head and Neck Surg. 1999 ; 125 (2) : 142-148   DOI