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http://dx.doi.org/10.14400/JDC.2018.16.11.613

Anti-inflammatory activity Effects of Mori Folium Water Extracton IL-1α, IL-6 and IL-10 on mouse macrophages  

Park, Young Sik (Department of Alternative medicine, Nambu University)
Han, Hyo-Sang (Department of Health Administration, Joongbu University)
Publication Information
Journal of Digital Convergence / v.16, no.11, 2018 , pp. 613-620 More about this Journal
Abstract
This study was conducted to investigate of Mori Folium Water Extract (MF) on anti-inflammation activity. MF Water extracts after 24 houres cultivation were examined to ascertain the cell viability of mouse macrophage RAW 264.7 cells. The influence of the Water extracts in RAW 264.7 macrophage cells treated with LPS was investigated. nitric oxide (NO) production, nterleukin$(IL)-1{\alpha}$ IL-6 and IL-10 increased generation of cytokines. mouse macrophage RAW 264.7 cells cell viability changes were no decreas after MTT assay of MF Water extract. The MF water extracts inhibited NO generation caused by LPS in the macrophages over $25{\mu}g/mL$. The MF water extracts increased in the control group the $IL-1{\alpha}$ and IL-6 activation generated by LPS in the macrophages over $50{\mu}g/mL$. Accordingly, it was found that different MF water extract concentrations significantly influenced certain anti-inflammation activities in RAW 264.7 macrophage cells. The results of this study are expected to be highly applicable to health - friendly functional materials. Further studies are needed to confirm the signaling pathways associated with anti-inflammation of macrophages through continuous studies.
Keywords
Mori Folium; Nitric oxide; Anti-inflammatory effect; Macrophage; Cytokine;
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Times Cited By KSCI : 8  (Citation Analysis)
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