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http://dx.doi.org/10.14400/JDC.2014.12.4.419

Skin Whitening Effects of Angelica koreana and Cnidium monnieri Extracts  

Cho, Wan Goo (Dept. of Basic Medical Science, Jeonju University)
Kim, Cheong Tack (R&S)
Publication Information
Journal of Digital Convergence / v.12, no.4, 2014 , pp. 419-425 More about this Journal
Abstract
The objective of this study is to estimate the inhibition of skin melanin formation by extract of Angelica koreana and Cnidium monnieri and the possibility of functional cosmetic materials through anti-irritation and stability test. The extract used in this experiment is White-$AK^{TM}$ and the INCI name is Osthole. The main component of White-$AK^{TM}$ was identified as coumarin and EC50 value was 2.7ppm by mouse melanoma B 16 cell test. White-$AK^{TM}$ showed inhibitory effects 100 times lower concentration than arbutin. The main mechanism for skin whitening effect thought to be inhibition of tyrosinase-related gene expression. The basic essence formulation of White-$AK^{TM}$ 5% solution applied to the skin showed the effect of relieving skin irritation. White-$AK^{TM}$ in an opaque container, under UV conditions for 4 weeks, and showed close to 100% recovery and 97% recovery under $50^{\circ}C$ for 4 weeks. Therefore, it is thought that White-$AK^{TM}$ which helps skin whitening, relieving skin irritation and stable in UV condition is able to be used as the functional component in the cosmetic formulation.
Keywords
Angelica koreana; Cnidium monnieri; tyrosinase; skin whitening; cosmetics;
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