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Relationship between Zinc Status and Obesity of Type 2 Diabetic Women  

Lee Jung Hee (Department of Food and Nutrition, Keimyung University)
Lee Hee Ja (Department of Food and Nutrition, Keimyung University)
Lee In Kyu (Department of Internal Medicine, Keimyung University)
Yoon Jin-Sook (Department of Food and Nutrition, Keimyung University)
Publication Information
Korean Journal of Community Nutrition / v.10, no.1, 2005 , pp. 70-78 More about this Journal
Abstract
Zinc is known to have important effects on insulin activity and to increase the body fat deposition. The purpose of this study was to investigate the zinc status and obesity in 50 type 2 diabetic women visiting public health center and hospital. The mean age was 57.9 $\pm$ 6.9 years old. The mean of diabetic duration was 8.0 $\pm$ 6.5 years. Body mass index (BMI) of diabetes was $23.2 \pm 2.3 kg/m^2$. There were no significant differences of mean age, anthropometric indices, and insulin level other than fasting blood sugar (p < 0.001) and insulin resistance (p < 0.00l) between diabetes and control group. The obesity ratio of diabetes was $20\%$, $66\%$ and $84\%$ for BMI, waist circumference and waist/hip ratio (WHR), respectively. Plasma zinc level was not significantly different between diabetes and control group. However, urinary zinc excretion of diabetes was approximately twice of control group (p < 0.001). Urinary zinc loss was fivefold higher in the hyperglycemia ($HbA_{lc}> 10\%$) than in normal blood glucose (p < 0.001). Anthropometric indices were decreased in hyperglycemia. On the other hand, there were the tendency of increased urinary zinc in obese group for waist circumference and percent of body fat. These results suggested that controlled normal blood glucose could improve hyperzincuria and anthropometric changes in type 2 women diabeties.
Keywords
diabetes; anthropometric indices; insulin; hyperzincuria; hyperglycemia;
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1 Chooi MK, Todd JK, Boyd ND (1976): Influence of age and sex on plasma zinc levels in normal and diabetes individuals. Nutr Metab 20: 135-142   DOI   PUBMED
2 Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M (1998): Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339: 229-234   DOI   ScienceOn
3 Huh KB, Lee JH, Paik IK, Ahn KJ. Jung YS, Kim MJ, Lee HC, Lee YH. Lee YJ (1993): Influence of total abdominal fat accumulation on serum lipids and lipoproteins in Korean middle-aged men. Kor J Nutrition 26(3): 299-312
4 Kim AJ (1988): A study on intake of iron, copper, zinc and blood contents of rural women in Korea. Master thesis, Sookmyung Women's University, Korea
5 Kim SY, Oh YS, Lee HK, Min HK (1985) : Zinc and copper metabolism in diabetes. J Kor Diabetes Associ 9 (1) : 81-88
6 Kinlaw WB, Levine AS, Morley JE, Silvis SE, McClain CJ (1983): Abnormal zinc metabolism in type II diabetes mellitus. Am J Med 75: 273-277   DOI   ScienceOn
7 Korean Food Research Institute (1998): Handbook of Portion Size for Food Intake Research. Seoul
8 Lee JY, Choi MK, Sung CJ (1996): The relationship between dietary intakes, serum levels, urinary excretions of Zn, Cu, Fe, and serum lipids in Korean rural adults on self-selected diet. Kor J Nutr 29 (10) : 1112-1120
9 Lee JY, Paik HY, Joung HJ (1998): Supplementation of zinc nutrient database and evaluation of zinc intake of Korean adults living in rural area. Kor J Nutr 31 (8): 1324-1337
10 Levine AS, McClain CJ, Handwerger BS, Brown DW, Morley JE (1983): Tissue zinc status of genetically diabetic and streptozotocin induced diabetic mice. Am J Clin Nutr 37: 382-386   DOI
11 Nam JH, Lee SH, Lee HJ, Han JH, Kim JG, Ha SW, Kim BW (1999): The prevalence of chronic complications in non-insulin dependent diabetic patients. J Kor Diabetes Associ 23 (5): 702-714
12 Nam JH, Park SW, Ahn CW, Song YD, Lim SK, Kim KR, Lee HC, Huh KB (2001) : Atherosclerotic severity and risk factors in type 2 diabetic patients with viceral (metabolic) obesity in Korea. J Kor Diabetes Associ 25 (1) : 20-34
13 Pidduck HG, Wren PJJ, Price Evans DA (1970): The hyperzincuria of diabetes mellitus and possible genetic implications of this observation. Diabetes 19(4): 240-247   DOI
14 Song TH, Choi BR, Tak SM, Kang JW, Kim CE, Moon FC, Woo JT, Kim EJ (1990): A Retrospective study on body weight of diabetes in Korea. J Kor Diabetes Associ 14 (2) : 229-233
15 Wada L, King JC (1986): Effect of low zinc intake in basal metabolic rate, thyroid hormones and protein utilization in adult men. J Nutr 116: 1045-1053   DOI
16 King JC, Shames DM, Woodhouse LR (2000): Zinc homeostasis in humans. J Nutr May 130 (5S Suppl) : 1360S-1366S
17 Barakat RG, Burton DS. Carpenter JW. Holbert D, Israel RG (1988): Body fat distribution, plasma lipoproteins and the risk of coronary heart disease of male subjects. Int J Obes 12: 473-480
18 Bauer JD (1982): Clinical Laboratory Methods, 9th ed. The C.V. Mosby Company, pp.518-519
19 Hawk PB. Oser BL, Summerson WH (1954) : Practical physiology chemistry. 13th ed. Blakiston co Inc Toronto, p.899
20 Dowlati B, Firooz A, Khamesipour A, Lotfi M, Stuart CA, Smith EB. Larijani B, Dowlati Y (1998) : Insulin quantification in patients with seborrheic dermatitis. Arch Dermatol 134(8): 1043-1045   DOI   ScienceOn
21 Mateo MCM, Bustamante JB, Cantakaouedra MAG (1978): Serum zinc, copper and insulin in diabetes mellitus. Biomedicine 29: 56-58
22 Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN. Schwartz MW. Neifing JL, Ward WK, Beard JC, Palmer JP (1993): Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function Diabetes 42: 1663-1672
23 Mooradian AD, Morley JE (1987): Micronutrient status in diabetes mellitus. Am J Clin Nutr 45: 877-895   DOI
24 Tungtrongchitr R, pongpaew P, Phonrat B, Tungtrongchitr A, Viroonudomphol D, Vudhivai N, Schelp FP (2003) : Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese. J Med Assoc Thai 86 (6) : 543-551
25 Goldstein DE, Little RR, Wiedmeyer HM, England JD, McKenzie EM (1986): Glycated hemoglobin: methodologies and clinical applications. Clin Chem 32 (10 Suppl) : B64-70
26 Canfield WK, Hambidge KM (1982): Zinc nutriture in children and young adult. Fed Pro 41: 1088
27 Chen MD, Lin PY. Sheu WH (1997): Zinc status in plasma of obese individuals during glucose administration. Biol Trace Elem Res 60 (1-2): 123-129   DOI   PUBMED   ScienceOn
28 Marreiro DN, Fisberg M, Cozzolino SM (2002): Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res 100(2): 137-150   DOI   ScienceOn
29 Lee DJ, Kim SM, Lee EJ, Kwon HC, Cho NH, Chung YS (1996): Estimation of relative risk for obesity and WHR associated disease in women. J Kor Soci Study Obesity 5 (1) : 41-48
30 Lofgren I, Herron K, Zern T, West K, Patalay M, Shachter NS, Koo SI, Fernandez ML (2004): Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women. J Nutr 134: 1071-1076   DOI
31 Chen MS, Kao CS, Chang CJ, Wu TJ, Fu CC, Chen CJ, Tai TY (1992): Prevalence and risk factors of diabetic subjects. Am J Ophthalmol 114: 723-730   DOI
32 The Korean Nutrition Society (2000): Recommended Dietary Allowances for Koreans. 7th revision, Seoul
33 Klein R, Klein BE, Moss SE (1996): Relation of glycemic control to diabetic microvascular complications in diabetic mellitus. Am Intern Med 124: 90-96   DOI   ScienceOn
34 National Diabetes Data Group (1976): Community screening for diabetes by blood glucose measurement. Results of a five year experence. Diabetes 25: 1110   DOI   ScienceOn
35 Coulston L, Dandonn P (1980) : Insulin like effect of zinc on adipocytes. Diabetes 29: 665-667   DOI   ScienceOn
36 Min HK (1992): Clinical characteristics of diabetes in korea. J Kor Diabetes Associ 16(3): 163-174
37 Choi YS, Park SH. Kim BW (2000): The clinical significance of anthropometric measurements of obesity in type 2 diabetes. J Kor Diabetes Associ 24 (3) : 365-374
38 Gibson RS, Heath AL, Limbaga ML, Prosser N, Skeaff CM (2001): Are changes in food consumption patterns associated with lower biochemical zinc status among women from Dunedin, New Zealand? Br J Nutr 86(1): 71-80   DOI   ScienceOn
39 Failla ML, Kiser RA (1981): Altered tissue content and cytosol distribution of trace metal in experimental diabetes. J Nutr 111: 1900-1909   DOI
40 Shin SY (1989) : A study on blood and urine contents of iron, copper, zinc in rural women. Master thesis, Sookmyung Women's University, Korea
41 Cho JK, Kim HM, Lim SK. Whang Y, Lee HC. Huh KB (1986): A study on change of body weight of non-insulin dependent diabetes mellitus. J Kor Diabetes Associ 10(1) : 89-93
42 Onat A, Avci GS, Barlan MM, Uyarel H, Uzunlar B, Sansoy V (2004): Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk. Int J Obes Relat Metab Disord 28(8) : 1018-1025   DOI   PUBMED   ScienceOn
43 Park JH, Ro SR, Oh YS, Shinn SH (1991) : A study on the zinc, copper and chromium content in serum and 24-hr urine of normal subjects and non-insulin dependent diabetics. J Kor Diabetes Associ 15 (1) : 109-120
44 Evans DJ, Hoffman RG, Kalkhoff RK, Kissbah AH (1984): Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. Metabolism 33: 68-75   DOI   ScienceOn
45 Mieling GE, Pardue HL, Thompson JE, Smith RA (1979): A kinetic method for glucose that is insensitive to variations in temperature and enzyme activity. Clin Chem 25 (9): 1581-1590
46 Cikim AS, Ozbey N, Orhan Y (2004): Relationship between cardiovascular risk indicators and types of obesity in overweight and obese women. J Int Med Res 32 (3): 268-273   DOI   ScienceOn
47 Huh KB, Ahn KJ, Lee HC, Lim SK, Lee YH (1993): Influence of viceral fat accumulation on carbohydrate metabolism in Korean middle-aged women. Kor J Internal Medicine 44(4): 648-658