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Iron Status Indices of Maternal, Umbilical Cord, Placenta and Birth Weight  

배현숙 (성신여자대학교 식품영양학과)
이금주 (성신여자대학교 식품영양학과)
이민숙 (성신여자대학교 식품영양학과)
이주예 (성신여자대학교 식품영양학과)
신용미 (성신여자대학교 식품영양학과)
안홍석 (성신여자대학교 식품영양학과)
Publication Information
Korean Journal of Community Nutrition / v.7, no.5, 2002 , pp. 686-695 More about this Journal
Abstract
The purpose of this study is to assess the maternal iron status during pregnancy and to evaluate the relationships bet-ween the iron indices of maternal, umbilical cord serum, placenta and pregnancy outcomes. Venous bloods samples were drawn from 54 pregnant women just before delivery and cord bloods of their newborn babies were collected immediately after birth. And also, placental tissues were extracted. We investigated the difference of the iron status indices of maternal, umbilical cord serum and placental tissue between two gestational age group (PT group, NT group : preform delivery and normal term delivery at 34.9wk and 39.0wk of mean gestational length, respectively) and also assessed correlations of iron status indices of maternal, umbilical cord serum and placenta tissue. And lastly, we related between birth weight and iron status indices of maternal, umbilical cord serum and placental tissue. The concentrations of maternal serum ferritin and of placental iron were significantly higher in NT group (32.1 $\pm$ 21.1 ng/ml, 68.5 $\pm$ 16.7 $\mu$g/g), than those of NT group (20.8 $\pm$ 11.6 ng/ml, 53.2 $\pm$ 17.4 $\mu$/g) respectively (p<0.001). However the serum ferritin of umbilical cord were significantly higher in NT group (PT : 109.4 $\pm$ 65.7 ng/ml, NT : 147.0 $\pm$ 56.8 ng/ml) than those of PT group (p<0.05). Our results showed that a negative association between birth weight (r=-0.361) and maternal serum ferritin and that a positive association between birth weight and umbilical cord serum ferritin (r=0.261). Despite not a significant difference, there was tendency that highest concentration of maternal serum ferritin was associated with the lowest birth weight. These findings indicate that birth weight of newborn is dependent of multiple factors such as maternal iron status during pre-pregnancy, body size, general nutritional status. Although for women who enter pregnancy with low iron stores, enough intakes of iron during pregnancy could produce undesirable pregnancy outcome. Therefore we suggest for successful pregnancy outcome and delivery differential iron supplementation program will be carried out individual pregnant women on the basis of pre-pregnancy nutritional status.
Keywords
iron status; gestational length; birth weight; pregnancy outcome;
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1 World Health Organization (1992): The prevalence of anemia in women: A tabulation of available information 2nd ed. Geneva, World Health Organization
2 Yu KH, Yoon JS (1998): The effect of weekly iron supplementation on iron and zinc nutritional status in pregnant women. Korean J Nutrition 31 (8): 1270-1282
3 World Health Organization (1968): Nutritional anemia. WHO Tech Rep Ser 405:1-36
4 Yu KH, Yoon JS (1999): A cross-sectional study of nutrient intakes by gestational age and pregnancy outcome (I). Korean J Nutrition 32(8):877-886
5 Yu KH, Yoon JS, Hahm YS (1999): A cross-sectional study of bichemical analysis and assessment of iron deficiency by gestational age (II). Korean J Nutrition 32 (8):887-896
6 Kim EK, Lee KH (1998): Assessment of the intake and availability of dietary iron and nutrition knowledge in pregnant women. Korean J Community Nutrition 3 (1): 53-61
7 Ahn HS, Kim JS, Lee GJ, Kim YT (2000a): Serum folate levels of maternal-umbilical cord blood and pregnancy outcomes. Korean J Nutrition 33 (8): 840-847
8 Johnson AA, Knigh EM, Edwards CH, Oyemade UJ, Cole OJ, Westney OE, Westney LS, Laryea H, Jones S (1994): Dietary intakes, anthropometric measurements and pregnancy outcomes. J Nutr 124 (suppl): 936S-942S
9 Kardar N, Caldwell BV, Romero R (1981): A methed of screening for ectopic pregnancy and its indications. Obstet & Gynecol 58: 162
10 Lee HL, Wee SN, Moon EJ, Lim SH, Choi YJ, Kim C (1990) : The epidemiologic and clinical study of hypertensive disorders in pregnancy. Korean Journal of Obstetrics and Gynecology 33:1382-1391
11 Lee MJ (1982): A study on the nutritional status of the pregnant and the lactating women and the newborn babies in Samchuk-Gun district. Ewha Women's University. A thesis for a doctorate
12 Okuyama T, Tawada T, Furuya H, Villee CA (1985): The role of transferrin and ferritin in the fetal-maternal-placental unit. Am J Obstet Gynecol 152:344-350
13 Picciano MF (1996): Present knowledge in nutrition 7th edition. In): 37. Pregnancy and lactation. International Life Sciences Institute pp.390-401
14 Rasmussen KM (2001): Is there a causal relationship between iron deficiency or iron- deficiency anemia and weight at birth, length of gestation and perinatal mortality?. J Nutr 131:590s-603s
15 Song YS, Kim SH (1989): Nutritional status of rural pregnant women in relation to physical condition of offspring at birth. Korean J Nutrition 22:547-556
16 Stekel A (1984): Iron requirements in infancy and childhood. In: Iron nutritionin infancyand childhood. New York: RavenPress, pp.1-10
17 Ahn HS, Lee GJ, Kim YT (2000b): Relationships between vitamin $B_6$ status of maternal-umbilical cord plasma and pregnancy outcomes. Korean J Nutrition 33 (3):263-270
18 Garn SM, Keatin MT, Falkner F (1981): Hematological status and pregnancy outcomes. Am J Clin Nutr 34:115
19 Scholl TO, Reilly TM (2000b): Clinical nutrition of the essential trace elements and minerals. In:8. Trace element and mineral nutrition in human pregnancy. Humana press, pp.115-119
20 Gibson RS (1990): Principles of nutritional assessment. Oxford University press, pp.181, 349-376
21 vanDijik JP (1988): Regulatory aspects of placental iron transfer -a comparative study. Placenta 9: 215
22 Scholl TO, Reilly TM (2000a): Anemia, iron and pregnancy outcome. J Nutr Fed: 130 (2S suppl):443S-447
23 Ahn HS, Kim JS, Lee GJ, Hong HK (2001): Serum vitamin $B_{12}$ levels of maternal-umbilical cord blood and pregnancy outcomes. Korean J Nutrition 34(4): 426-432
24 Finch CA, Huebers HA, Miller LR, Josephson BM, Shepard TH and Mackler B (1983): Fetal iron balance in the rat. Am J Clin Nutr 37:910-917
25 Rondo PH, Abbott R, Rodrigues LC, Tomkins AM (1997): The influence of maternal nutritional factors on intrauterine growth retardation in Brazil. Paediatr Perinat Epidemiol 11:152-166
26 Spper H, Guttmacher AF (1974): Frequency and significance of bleeding in early pregnancy. JAMA 155-172
27 Murphy JF, O'Riordan J, Newcombe RJ, Coles EC, Pearson JF (1986): Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet 1:992
28 Progress in chronic disease prevention (1990): Anemia during pregnancy in low income women-United States, 1987. MMWR 39(5): 73-75
29 Park SH, Ahn HS (1999): Dietary fat intake during pregnancy and serum lipid levels in mother and umbilical cord of full-term and preterm delivery. Korean J Nutrition 32 (5): 577-584
30 Steer PJ (2000): Maternal hemoglobin concentration and birth weight. Am J Clin Nutr 71 (suppl): 1285S-1287S
31 Sempos CT (1992): Some limitation of semiquantitative food frequency questionnaire. Am J Epid 135:1127-1132
32 Kim EK, Lee KH (1999): Iron status in pregnant women and their newborn infants. Korean J Nutrition 32 (7): 793-801
33 Milman N, Ibsen KK, Christensen JM (1987): Serum ferritin and iron status in mothers and newborn infants. Acta Obstet Gynecol Scand 66:205-211
34 Steer P, Alam MA, Wadsworth J, Welch A (1995): Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. BMI 310:489-491
35 The Korean Nutrition Society, Seoul (2000): Recommended dietary allowance for Koreans, 7th revision
36 Dallman PR (1989): Review of iron metabolism. In): Filer LJ, ed. Dietary iron: Birth to two years. New York: Raven Press, pp.1-18
37 Stephenson LS (1995): Possible new developments in community control of iron defi- ciency anemia. Nut Rev 53:23-30
38 Hindmarsh PC, Geary MP, Rodeck CH, Jackson MR, Kingdom JC (2000): Effect of early maternal iron stores on placental weight and structure. Lancet Aug 26:356 (9231):719-723
39 Meis PJ, Michielutte R, Peters TJ, Wells HB, Sands RE, Coles EC, Johns KA (1995): Factors associated with preterm birth in Cardiff Wales. Am J Obstet Gynecol 173:590-596
40 Park SH (1996): A study on the lipids intake pattern during pregnancy and maternal-umbilical cord serum lipid compositions of preterm and pregnancy induced hypertensive delivery groups. Sungshin Women's University. A thesis for a doctorate
41 Scholl TO (1998): High third trimester ferritin concentration; association with very preterm delivery infection and maternal nutritional status. Obstet GynecoI 92:161-165
42 Preziosi P, Prual A, Galan P, Daouda H, Boureima H, Hercberg S (1997): Effect of iron supplementation on the iron status of pregnant women: consequences for newborns. Am J Clin Nutr 66:1178-1782
43 Allen LH (2000): Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr 71 (suppl): 1280S-1284S
44 Lim HS, Kim HA (1998): Effects of maternal anemia on the iron status of the cord blood and pregnancy outcomes. Korean J Community Nutrition 3 (4): 565-573
45 Dreyfuss ML, Stolzfus RI, Shrestha JB, Khatry SK, Shrethsa SR, Pradhan EK, and West KP, Jr (1997): Pregnancy anemia and neonatal weight in rural Nepal. International congress of nutrition, Montreal July 27-August 1
46 Lao TT, Tam KF, Chan LY (2000): Third trimester iron status and pregnancy outcome in non-anaemia women ; pregnancy unfavourably affected by maternal iron excess. Hum Reprod Aug;15 (8): 1843-1848
47 Ramakrishnan U (2001): Nutrition anemias. In: 4. Functional consequences of nutrional anemia during pregnancy and early childhood. CRC press, pp.43-68, 2001
48 Agarwal KN, Agarwal DK, Mishra KP (1991): Impact of anaemia prophylaxis in preg- nancy on maternal hemoglobin, serum ferritin and birth weight. Indian J Med Res 94:277-80
49 Goldenberg RL, Tamura T, DuBard M, Johnston KE, Copper RL, Neggers Y (1996): Plasma ferritin and pregnancy outcome. Am J Obstet Gynecol 175:1356-1359, 1996   DOI   ScienceOn
50 Gupta GS, Singh J, Gupta A (1997): Trace metals and metalloenzymes in placenta after oral administration of lead acetate. BioI Trace Elem Res Oct-Nov:60(1-2):145-152