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http://dx.doi.org/10.7465/jkdi.2013.24.6.1349

Sample size determination based on placements for non-inferiority trials  

Kim, Jiyeon (Department of Statistics, The Catholic University of Korea)
Kim, Dongjae (Department of Statistics, The Catholic University of Korea)
Publication Information
Journal of the Korean Data and Information Science Society / v.24, no.6, 2013 , pp. 1349-1357 More about this Journal
Abstract
In clinical research, sample size determination is one of the most important things. There are parametric method using t-test and non-parametric method suggested by Kim and Kim (2007) based on Wilcoxon's rank sum test for determining sample size in non-inferiority trials. In this paper, we propose sample size calculation method based on placements method suggested by Orban and Wolfe (1982) and using the power calculated by Kim (1994) in non-inferiority trials. We also compare proposed sample size with that using Kim and Kim (2007)'s formula and that of t-test for parametric methods. As the result, sample size calculated by proposed method based on placements is the smallest. Therefore, proposed method based on placements is better than parametric methods in case that it's hard to assume specific distribution function for population and also more efficient in terms of time and cost than method based on Wilcoxon's rank sum test.
Keywords
Non-inferiority trial; placement; sample size;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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