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http://dx.doi.org/10.7465/jkdi.2013.24.6.1331

Major gene identification for LPL gene in Korean cattles  

Jin, Mi-Hyun (Department of Statistics, Yeungnam University)
Oh, Dong-Yep (Gyungsangbuk-Do Livestock Research Institute)
Lee, Jea-Young (Department of Statistics, Yeungnam University)
Publication Information
Journal of the Korean Data and Information Science Society / v.24, no.6, 2013 , pp. 1331-1339 More about this Journal
Abstract
The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. Oh etc (2013) investigated the relationship between unsaturated fatty acids and five novel SNPs, and had confirmed that three polymorphic SNPs (c.322G>A, c.329A>T and c.1591G>A) were associated with fatty acid composition. We have used generalized linear model for adjusted environmental effects and multifactor dimensionality reduction (MDR) method to identify gene-gene interaction effect of statistical model in general. We applied the MDR method on the identify major interaction effects of exonic single nucleotide polymorphisms (SNPs) in the LPL gene for economic traits in Korean cattles population.
Keywords
Gene interaction; genotype; mutifactor dimensionality reduction; single nucleotide polymorphism;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Casas, E., White, S. N., Riley, D. G., Smith, T. P. L., Brenneman, R. A., Olson, T.A., Johnson, D. D., Coleman, S. W., Bennett, G. L. and Chase, C. C. (2005). Assessment of single nucleotide polymorphisms in genes residing on choromosomes 14 and 29 for association with carcass composition traits in Bos indicus cattle. Journal of Animal Science, 83, 13-19.   DOI
2 Good, P. (2000). Permutation test: A practical guide to resampling methods for testing hypotheses, Springer-Verlag, New York.
3 Mandell, I., Buchanan-Smith, G. and C. P. Campbell. 1998. Effects of forage vs grain feeding on carcass characteristics, fatty acid composition, and beef quality in Limousin-cross steers when time on feed is controlled. Journal of Animal Science, 76, 2619-2630.   DOI
4 Matsuhashi, T., Maruyama, S., Uemoto, Y., Kobayashi, N., Mannen, H., Abe, T., Sakaguchi. S. and Kobayashi. E. (2011). Effects of bovine fatty acid synthase, stearoyl-coenzyme A desaturase, sterol regulatory element-binding protein 1, and growth ghormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle. Journal of Animal Science, 89, 12-22.   DOI   ScienceOn
5 Melton, S. L., Amiri, M., Davis, G. W. and Backus, W. R. (1982). Flavor and chemical characteristics of ground beef from grass-, forage-grain- and grain-finished steers. Journal of Animal Science, 55, 77-87.   DOI
6 Lee, J. H., Lee, Y. S., Lee, Y. W. and Lee, J. Y. (2011). A study on interaction effect among risk factors of delirium using multifactor dimensionality reduction method. Journal of the Korean Data & Information Science Society, 22, 1257-1264.   과학기술학회마을
7 Lee, J. Y., Kwon, J. C. and Kim, J. J. (2008). Multifactor Dimensionality reduction (MDR) analysis to detect single nucleotide polymorphisms associated with a carcass trait in a Hanwoo population. Journal of the Korean Data & Information Science Society , 21, 784-788.   과학기술학회마을   DOI
8 Lee, J. Y. and Lee, J. H. (2010a). Support vector machine and multifactor dimensionality reduction for detecting major gene interactions of continuous data. Journal of the Korean Data & Information Science Society , 21, 1271-1280.   과학기술학회마을
9 Lee, J. Y., Lee, J. H. and Lee, Y. W. (2010b). Detection of major genotype combination by genotype matrix. Journal of the Korean Data & Information Science Society, 21, 387-395.   과학기술학회마을
10 Oh, D. Y., Lee, Y. S., La, B. M., Yeo, J. S., Chung, E. Y., Kim, Y. Y. and Lee, C. Y. (2011). Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN. Molecular Biology Reports, 39, 4083-4090.
11 Oh, D. Y., La, B. M., Lee, Y. S., Byun, Y. H., Lee, J. Y., Yeo, G. H. and Yeo, J. S. (2013). Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle. Molecular Biology Reports, 40, 3155-3163.   DOI   ScienceOn
12 Velez, D. R., White, B. C., Motsinger, A. A., Bush, W. S., Ritchie, M. D., Williams, S. M. and Moore, J. H. (2007). A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genetic Epidemiology, 31, 306-315.   DOI   ScienceOn
13 Ritchie, M. D., Hahn, L. W., Roodi, N., Bailey, L. R., Dupont, W. D., Parl F. F. and Moore, J. H. (2001). Multifactor-dimensionality reduction reveals high-order interactions among estrogen- metabolism genes in sporadic breast cancer. American Journal of Human Genetics, 69, 138-147.   DOI   ScienceOn