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Detection of major genotypes combination by genotype matrix mapping  

Lee, Jea-Young (Department of Statistics, Yeungnam University)
Lee, Jong-Hyeong (Department of Statistics, Yeungnam University)
Lee, Yong-Won (Department of Statistics, Yeungnam University)
Publication Information
Journal of the Korean Data and Information Science Society / v.21, no.3, 2010 , pp. 387-395 More about this Journal
Abstract
It is important to identify the interaction of genes about human disease and characteristic value. Many studies as like logistic analysis, have associated being pursued, but, previous methods did not consider the sub-group of the genotypes. So, QTL interactions and the GMM (genotype matrix mapping) have been developed. In this study, we detect the superior genotype combination to have an impact on economic traits of Korean cattle based on the study over GMM method. Thus, we identified interaction effects of single nucleotide polymorphisms (SNPs) responsible for average daily gain(ADG), marbling score (MS), carcass cold weight (CWT), longissimus muscle dorsiarea (LMA) using GMM method. In addition, we examine significance of the major genotype combination selected by implementing permutation test of the F-measure which was not obtained by Sachiko et al.
Keywords
GMM (genotype matrix mapping); hanwoo Economic traits; SNP (single nucleotide polymorphisms);
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Lee, J. Y. and Lee, H. G. (2009). Multifactor dimensionality reduction (mdr) analysis by dummy variables. The Korean Journal of Applied Statistics, 22(2), 435-442   과학기술학회마을   DOI   ScienceOn
2 Snelling, W. M., Casas, E., Stone, R. T., Keele, J. W., Harhay, G. P., Benett, G. L. and Smith, T. P. L. (2005). Linkage mapping bovine EST-based SNP. BMC Genomics, 6, 74-84.   DOI   ScienceOn
3 Lee, J. Y., Kwon, J. C. and Kim, J. J. (2008a) Multifactor dimensionality reduction (mdr) analysis to detect single nucleotide polymorphisms associated with a carcass trait in a hanwoo population. Asian-Australian Journal of Animal Sciences 6, 784-788.
4 Lee, Y. S. (2009). Study on the identification of candidate genes and their haplotypes that are associated with growth and carcass traits in the QTL region of BTA6 in a Hanwoo population. Ph. D. Thesis, 1-94.
5 Ritchie, M. D., Hahn, L. W., Roodi, N., Bailey, L. R., Dupont, W. D., Parl, F. F. and Moore, J. H. (2001). Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. American Journal of Human Genetics, 69, 138-147.   DOI   ScienceOn
6 Sachiko, I., Akihiro, N. and Satoshi, T. (2007). Genotype matrix mapping: Searching for quantitive trait loci interactions in genetic variation in complex trait. DNA Research, 14, 217-225.   DOI   ScienceOn
7 Chung, Y. J., Lee, S. Y. and Park, T. S. (2005). Multifactor dimensionality reduction in the presence of missing observations. Journal of Korea Statistical Society, Proceedings of the Autumn Conference, 1, 31-36.
8 Efron, B. and Tibshirani, R. (1993). An introduction to the bootstrap, Champman & Hall/CRC, New York.
9 Good, P. (2000). Permutation test: A ractical guide to resampling method for testing hypotheses, Springer-Verlag Berlin and Heidelberg GmbH & Co., New York.