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Treatment of Diabetic Charcot Arthropathy  

Chung, Hyung-Jin (Department of Orthopedic Surgery, Sanggye Paik Hospital, Inje University Collage of Medicine)
Publication Information
Journal of Korean Foot and Ankle Society / v.17, no.4, 2013 , pp. 243-250 More about this Journal
Abstract
Diabetic Charcot arthropathy is a severe joint disease in the foot and ankle that can result in fracture, permanent deformity, limb loss. Although recent research has improved our level of knowledge regarding its etiology and treatment, it still remains a poorly understood disease. It is a serious and potentially limb-threatening lower-extremity late complication of diabetes mellitus and its diagnosis is commonly missed upon initial presentation. Clinicians treating diabetic patients should be vigilant in recognizing early signs of acute Charcot arthropathy, such as pain, warmth, edema, or pathologic fracture in a neuropathic foot. Early detection and prompt treatment can prevent joint and bone destruction. If left untreated, it can reduce overall quality of life and dramatically increase morbidity and mortality of patients. The goal of this manuscript is to evaluate the current concepts of Charcot arthropathy through review of various literature and help clinicians decide the treatment strategy.
Keywords
Foot and ankle; Diabetic charcot athropathy; Current concepts;
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1 Sanders LJ, Fryberg RG. The Charcot foot. In: Bowker JH, Pfeifer MA, eds. Levin and O'Neal's the diabetic foot, 7th ed. Philadelphia: Mosby Elsevier; 2007. 257-83.
2 Pinzur MS. Current concepts review: Charcot arthropathy of the foot and ankle. Foot Ankle Int. 2007;28:952-9.   DOI   ScienceOn
3 Klenerman L. The Charcot joint in diabetes. Diabet Med. 1996;13 Suppl 1:524.
4 Bowker JH, Pfeifer MA. Levin and O'Neal's the Diabetic Foot, 7th ed. Philadelphia: Mosby Elsevier 2008.
5 Dalla PL, Volpe A, Varotto D, et al. Use of a retrograde nail for ankle arthrodesis in Charcot neuroarthropathy: a limb salvage procedure. Foot Ankle Int. 2007;28:967-70.   DOI   ScienceOn
6 Nielson DL, Armstrong DG. The natural history of Charcot's neuroarthropathy. Clin Podiatr Med Surg 2008; 25:53-62.   DOI
7 Perrin BM, Gardner MJ, Suhaimi A, Murphy D. Charcotosteoarthropathy of the foot. Aust Fam Physician. 2010;39:117-9.
8 van der Ven A, Chapman CB, Bowker JH. Charcot neuroarthropathy of the foot and ankle. J Am Acad Orthop Surg. 2009;17:562-71.   DOI
9 Baumhauer JF, O'Keefe R, Schon L, Pinzur MS. Cytokine induced osteoclastic bone resorption in Charcot arthropathy: an immunohistochemical study. Foot Ankle Int. 2006;27:797-800   DOI
10 Molines L, Darmon P, Raccah D. Charcot's foot: Newest findings on its pathophysiology, diagnosis and treatment. Diabetes & Metabolism. 2010;36:251-55.   DOI   ScienceOn
11 Schon LC, Easley ME, Seinfeld SB. Charcot neu roarthropathy of the foot and ankle. Clin Orthop. 1998;349: 116-31.   DOI
12 Brodsky JW. The diabetic foot, in Coughlin MJ, Mann RA, Saltzman CL, eds: Surgery of the Foot and Ankle, 8th ed .St. Louis, MO: Mosby; 2006. 1281-368.
13 Rogers LC, Bevilacqua NJ. The diagnosis of Charcot foot. Clin Podiatr Med Surg. 2008;25:43-51.   DOI
14 Richardson DR. Amputation of the foot. In: Canale ST and Beaty JH eds. Campbell's operative orthpaedics. 11th ed, Philadelphia: Mosby Elsevier; 2008. 579-98.
15 Alexander van der Ven, MBACary B. Chapman, John HB. Charcot Neuroarthropathy of the Foot and Ankle. AAOS 2009.
16 Hofbauer LC, Hamann C, Ebeling PR. Approach to the patient with secondary osteoporosis. Eur J Endocrinol. 2010:162:1009-20.   DOI   ScienceOn
17 Guven MF, Karabiber A, Kaynak G, Ogut T. Conservative and surgical treatment of the chronic Charcot foot and ankle. Diabet Foot Ankle. 2013
18 Wukich DK, SungW. Charcot arthropathy of the foot and ankle: modern concepts and management review. J Diabetes Complications. 2009;23:409-26.   DOI   ScienceOn
19 Ulbrecht JS, Wukich DK. The Charcot foot: medical and surgical therapy. Curr Diabetes Rep. 2008; 8:444-51.   DOI   ScienceOn
20 Bern R, Jirkovska A, Fejfarova V, Skibova J, Jude EB. Intranasal calcitonin in the treatment of acute Charcot neuroosteoarthropathy: a randomized controlled trial. Diabetes Care. 2006;29:1392-4.   DOI   ScienceOn
21 Rogers MJ. New insights into the molecular mechanisms of action of bisphosphonates. Curr Pharm Des. 2003;9:2643-58.   DOI   ScienceOn
22 Grant WP, Jerlin EA, Pietrzak WS, Tam HS. The Utilization of autologous growth factors for the facilitation of fusion in complex neuropathic fractures in the diabetic population. Clin Podiatr Med Surg. 2005;22:561-84.   DOI   ScienceOn
23 Coughlin MJ, Smith BW, Traughber P. The evaluation of the healing rate of subtalar arthrodeses, part 2: the effect of low-intensity ultrasound stimulation. Foot Ankle Int. 2008; 29:970-7.   DOI   ScienceOn
24 Wukich DK, Sung WJ. Charcot arthropathy of the foot and ankle: modern concepts and management review. Journal of Diabetes and Its Complications. 2009;23:409-26.   DOI   ScienceOn
25 Bibbo C, Lin SS, Beam HA,Behrens FF. Complications of ankle fractures in diabetic patients. Orthop Clin North Am. 2001;32:113-33.   DOI
26 Monroe MT, Beals TC, Manoli A 2nd. Clinical outcome of arthrodesis of the ankle using rigid internal fixation with cancellous screws. Foot Ankle Int. 1999;20:227-31.   DOI   ScienceOn
27 Lowery NJ, Woods JB, Armstrong DG, Wukich DK. Surgical management of Charcot neuroarthropathy - a systematic review. Foot Ankle Int. 2012;2:33-5.
28 Zarutsky E, Rush SM, Schuberth JM. The use of circuler wire external fixation in the treatment of salvage ankle arthrodesis. J Foot Ankle Surg. 2005;44:22-31.   DOI   ScienceOn
29 Varam AK. Charcot Neuroarthropathy of the Foot and Ankle: A Review. J Foot Ankle Surg. 2013;52:740-9.   DOI   ScienceOn