Browse > Article
http://dx.doi.org/10.15268/ksim.2019.7.3.127

The Relationship Between Serum Triglyceride/HDL Cholesterol, Total Cholesterol/HDL Cholesterol, LDL Cholesterol/HDL Cholesterol Ratios and Cardiovascular Disease Risk Factors in Korean Adults: Using the 2016 Korea National Health and Nutrition Examination Survey Data  

Yoo, Areum (Dept. of Family Medicine, Wonkwang University Hospital)
Shin, Saeron (Dept. of Family Medicine, Wonkwang University Hospital)
Publication Information
Journal of The Korean Society of Integrative Medicine / v.7, no.3, 2019 , pp. 127-139 More about this Journal
Abstract
Purpose : The lipid profile is a major predictive index for cardiovascular disease, but there have only been a few studies conducted on the relationship between lipid ratio and cardiovascular disease risk factors in the Korean population. To address this research gap, we investigated the association between three lipid ratios and cardiovascular disease risk factors among Korean adults. Methods : This study used data from the seventh Korea National Health and Nutrition Examination Survey conducted in 2016. Lipid ratios included triglyceride (TG)/high density lipoprotein cholesterol (HDL), total cholesterol (TC)/HDL, and low density lipoprotein cholesterol (LDL)/HDL. Cardiovascular risk factors included in this research were: systolic blood pressure $(SBP){\geq}140$, diastolic blood pressure $(DBP){\geq}90$, fasting blood sugar $(FBS){\geq}126$, $HbA1c{\geq}6.5$, body mass index $(BMI){\geq}25$, waist circumference (WC) $men{\geq}90$, $women{\geq}85$, and metabolic syndrome (MetS). A complex samples logistic regression test was performed to analyze the association between lipid ratios and cardiovascular disease risk factors. Results : 1) TG/HDL ratio had statistically significant relationships with DBP, FBS, HbA1c, BMI, WC and MetS. 2) TC/HDL ratio was correlated to SBP, DBP, FBS, BMI, WC, and MetS. 3) LDL/HDL ratio had association with BMI, WC, and MetS. Conclusion : We identified significant association between lipid ratios and cardiovascular disease risk factors. The three lipid ratios were particularly strongly associated with BMI, WC, and MetS.
Keywords
cardiovascular disease risk factors; LDL/HDL ratio; TC/HDL; TG/HDL;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Ardern C, Katzmarzyk P, Janssen I, et al(2003). Discrimination of health risk by combined body mass index and waist circumference. Obes Res, 11(1), 135-142.   DOI
2 Assmann G, Schulte H, von Eckardstein A, et al(1996). High density lipoprotein cholesterol as a predict of coronary heart disease risk, The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis, 124, 11-20.   DOI
3 Beaglehole R, Bonita R, Horton R, et al(2011). Priority actions for the noncommunicable disease crisis. Lancet, 377(9775), 1438-1447.   DOI
4 Cho HK(2006). Diabetes mellitus and disorder of lipid metebolism. J Korean Soc Endocrinol, 21(2), 101-105.   DOI
5 Choi CS(2009). Pathogenesis of insulin resistance. Korean J Med, 77(2), 171-177.
6 Choi JS, Lee JE, Sang JE, et al(2017). A comparison of predictability of physician diagnosed dyslipidemia according to increased blood pressure, blood sugar and waist circumference: A nationwide population based retrospective cohort study. Korean J Fam Pract, 7(1), 137-143.   DOI
7 Ha KH, Kwon HS, Kim DJ(2015). Epidemiologic characteristics of dyslipidemia in Korea. J Lipid Atheroscler, 4(2), 93-99.   DOI
8 Isomaa B, Almgren P, Tuomi T, et al(2001). Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care, 24(4), 683-689.   DOI
9 Jee SH, Song JW, Cho HK, et al(2004). Development of the individualized health risk appraisal model of ischemic heart disease risk in Korea. Korean Society of Lipidology and Atherosclerosis, 14(2), 153-168.
10 Kim HC, Oh SM(2013). Noncommunicable diseases: current status of major modifiable risk factors in Korea. J Prev Med Public Health, 46(4), 165-172.   DOI
11 Kimm HJ, Lee SW, Lee HS, et al(2010). Associations between lipid measures and metabolic syndrome, insulin resistance and adiponectin. Circ J, 74(5), 931-937.   DOI
12 Kim JH, Kwon HS, Park YM, et al(2007). Best surrogate marker for insulin resistance in middle aged non-diabetic Korean; Chungju metabolic syndrome study. Korean J Med, 73(6), 611-617.
13 Kim JS, Kang HT, Shim JY, et al(2012). The association between the triglyceride to high-density lipoprotein cholesterol ratio with insulin resistance (HOMA-IR) in the general Korean population: Based on the National Health and Nutrition Examination Survey in 2007-2009. Diabetes Res Clin Pract, 97(1), 132-138.   DOI
14 Kim MK, Park JH(2012). Metabolic syndrome. J Korean Med Assoc, 55(10), 1005-1013.   DOI
15 Kim YC, Rhee EJ, Yoo TW, et al(2005). Comparison of insulin resistance and serum hsCRP levels according to the fasting blood glucose and blood pressure in nondiabetic and normotensive range. Korean J Med, 68(2), 178-185.
16 Lee SW, Koo ES, Kim BS, et al(1998). The relationships between blood pressure and serum lipids in korean adults. Korean Circ J, 28(9), 1552-1560.   DOI
17 Lee JS, Chang PY, Zhang Y, et al(2017). Triglyceride and HDL-C dyslipidemia and risks of coronary haera disease and ischemic stroke by glycemic dysregulation status: The Strong Heart Study. Diabetes Care, 40(4), 529-537.   DOI
18 Lemieux I, Lamarche B, Couillard C, et al(2001). Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in man: the Quebec Cardio Vascular Study. Arch Int Med, 161(22), 2685-2692.   DOI
19 Murata K, Terasawa F, Hosoda S, et al(1971). Relation of blood pressure and serum total cholesterol to severity of atherosclerotic lesions in aorta, coronary and cerebral arteries. Jpn Heart J, 12(5), 460-466.   DOI
20 McLaughlin T, Abbasi F, Cheal K, et al(2003). Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Int Med, 139(10), 802-809.   DOI
21 Oh SY, Kim SH, Hwang IC(2014). Relationship between metabolic syndrome and triglyceride/high density lipoprotein cholesterol ratio. Korean J Clin Geriatr, 15(2), 69-74.   DOI
22 Onat A, Can G, Kaya H, et al(2010). Atherogenic index of plasma (log10 triglyceride/high-density lipoproteincholesterol) predicts high blood pressure, diabetes, and vascular events. J Clin Lipidol, 4(2), 89-98.   DOI
23 Otsuka T, Takada H, Nishiyama Y, et al(2016). Dyslipidemia and the risk of developing hypertension in a working-age male population. J Am Heart Assoc, 5(3), e003053.   DOI
24 Park E, Kim J(2015). Gender- and age-specific prevalence of metabolic syndrome among korean adults: analysis of the fifth Korean National Health and Nutrition Examination Survey. J Cardiovasc Nurs, 30(3), 256-266.   DOI
25 Park JM, Kang SM, Lee JW, et al(2015). Correlation between the ratio of triglyceride to high-density lipoprotein cholesterol and fasting glucose & hemoglobin A1c. Korean J Fam Pract, 5(3), 462-467.
26 Park KR, Cho YC(2010). The abnormal rates of blood pressures and blood biochemical properties with BMI in health checkup examinees. Journal of the Korea Academia-Industrial Cooperation Society, 11(12), 4843-4853.   DOI
27 Rubenfire M, Brook RD(2013). HDL cholesterol and cardiovascular outcomes: what is the evidence?. Curr Cardiol Rep, 15(4), 349.   DOI
28 Shin SH, Lee TY(2012). Associations of serum lipid profiles with incidence of ischemic heart diseases in Korean adult: retrospective cohort study. Journal of the Korea Academia-Industrial Cooperation Society, 13(5), 2219-2231.   DOI
29 Tohidi M, Hatami M, Hadaegh F, et al(2012). Triglycerides and triglycerides to high-density lipoprotein cholesterol ratio are strong predictors of incident hypertension in Middle Eastern women. J Hum Hypertens, 26(9), 525-532.   DOI
30 Wijeysundera HC, Machado M, Farahati F, et al(2010). Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005. JAMA, 303(18), 1841-1847.   DOI
31 Witztum JL, Steinberg D(1991). Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest, 88(6), 1785-1792.   DOI
32 Yoon HS, Bae SY, Cho YC(2015). Relationship between obesity indices and serum lipid levels in adult using data from health examination. Journal of the Korea Academia-Industrial Cooperation Society, 16(2), 1145-1152.   DOI
33 Yusuf S, Hawken S, Ounpuu S, et al(2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries(the interheart study): case-control study. Lancet, 364(9438), 937-952.   DOI
34 Health insurance review & assessment service. National health insurance statistical yearbook, 2016. Available at https://www.hira.or.kr/bbsDummy.do?pgmid=HIRAA020045020000&brdScnBltNo=4&brdBltNo=2309&pageIndex=1#none. Accessed August 7, 2019.
35 Statistics Korea. Annual report on the cause of death statistics, 2017. Available at http://www.kostat.go.kr. Accessed February 25, 2019.
36 World Health Organization. World health statistics 2018 monitoring health for the SDGs, sustainable development goals, 2018. Available at https://apps.who.int/iris/bitstream/ handle/10665/272596/ 9789241565585-eng.pdf?sequence=1&isAllowed=y. Accessed February 25, 2019.