MicroRNA-200a Targets Cannabinoid Receptor 1 and Serotonin Transporter to Increase Visceral Hyperalgesia in Diarrhea-predominant Irritable Bowel Syndrome Rats |
Hou, Qiuke
(Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine)
Huang, Yongquan (Department of Orthopedics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine) Zhang, Changrong (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Zhu, Shuilian (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Li, Peiwu (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Chen, Xinlin (Department of Preventive Medicine and Health Statistics, Guangzhou University of Chinese Medicine) Hou, Zhengkun (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Liu, Fengbin (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine) |
1 | Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 1984;87:1344-1350. DOI |
2 | Booth C, Patel S, Bennion GR, Potten CS. The isolation and culture of adult mouse colonic epithelium. Epithelial Cell Biol 1995;4:76-86. |
3 | Ren HX, Zhang FC, Luo HS, Zhang G, Liang LX. Role of mast cell-miR-490-5p in irritable bowel syndrome. World J Gastroenterol 2017;23:93-102. DOI |
4 | Zhou Q, Verne GN. miRNA-based therapies for the irritable bowel syndrome. Expert Opin Biol Ther 2011;11:991-995. DOI |
5 | Fourie NH, Peace RM, Abey SK, et al. Elevated circulating miR-150 and miR-342-3p in patients with irritable bowel syndrome. Exp Mol Pathol 2014;96:422-425. DOI |
6 | Koukos G, Polytarchou C, Kaplan JL, et al. A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium. Inflamm Bowel Dis 2015;21:996-1005. DOI |
7 |
Zhou Q, Costinean S, Croce CM, et al. MicroRNA 29 targets nuclear factor- |
8 | Zhou Q, Yang L, Larson S, et al. Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1. Gut 2016;65:797-805. DOI |
9 | Liao XJ, Mao WM, Wang Q, Yang GG, Wu WJ, Shao SX. MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome. Biochem Biophys Res Commun 2016;469:288-293. DOI |
10 | Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science 2010;329:1537-1541. DOI |
11 | Neesse A, Gress TM. Emerging role of microRNAs to tackle drug resistance in pancreatic cancer. Gut 2015;64:1842-1843. DOI |
12 | Kalla R, Ventham NT, Kennedy NA. MicroRNAs: new players in inflammatory bowel disease. Gut 2015;64:1008. DOI |
13 | Zhang L, Cheng J, Fan XM. MicroRNAs: new therapeutic targets for intestinal barrier dysfunction. World J Gastroenterol 2014;20:5818-5825. DOI |
14 | Wu F, Zikusoka M, Trindade A, et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 2008;135:1624-1635, e24. DOI |
15 | Kalla R, Ventham NT, Kennedy NA, et al. MicroRNAs: new players in IBD. Gut 2015;64:504-517. DOI |
16 | Nguyen HT, Dalmasso G, Muller S, Carriere J, Seibold F, Darfeuille-Michaud A. Crohn's disease-associated adherent invasive Escherichia coli modulate levels of microRNAs in intestinal epithelial cells to reduce autophagy. Gastroenterology 2014;146:508-519. DOI |
17 | Hou Q, Huang Y, Zhu S, et al. MiR-144 increases intestinal permeability in IBS-D rats by targeting OCLN and ZO1. Cell Physiol Biochem 2017;44:2256-2268. DOI |
18 | Hong S, Zheng G, Wiley JW. Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system. Gastroenterology 2015;148:148-157, e7. DOI |
19 | Vianna CR, Donato J Jr, Rossi J, et al. Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility. J Neurosci 2012;30:10331-10337. |
20 | Hong S, Fan J, Kemmerer ES, Evans S, Li Y, Wiley JW. Reciprocal changes in vanilloid (TRPV1) and endocannabinoid (CB1) receptors contribute to visceral hyperalgesia in the water avoidance stressed rat. Gut 2009;58:202-210. DOI |
21 | Reigstad CS, Linden DR, Szurszewski JH, Sonnenburg JL, Farrugia G, Kashyap PC. Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes. Neurogastroenterol Motil 2016;28:1443-1448. DOI |
22 | Cui XF, Zhou WM, Yang Y, et al. Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome. World J Gastroenterol 2014;37:13521-13529. |
23 | Gutierrez B, Bellon JA, Rivera M, et al. The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. J Psychiatry Neurosci 2015;40:187-196. DOI |
24 | Wolmarans de W, Brand L, Stein DJ, Harvey BH. Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessivecompulsive disorder (OCD): response to escitalopram treatment and basal serotonin transporter (SERT) density. Behav Brain Res 2013;256:545-553. DOI |
25 | Charoenphandhu J, Teerapornpuntakit J, Nuntapornsak A, Krishnamra N, Charoenphandhu N. Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphe of estrogen- and fluoxetine-treated ovariectomized rats. Pharmacol Biochem Behav 2011;98:503-510. DOI |
26 | Winston J, Shenoy M, Medley D, Naniwadekar A, Pasricha PJ. The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats. Gastroenterology 2007;132:615-627. DOI |
27 | Sikander A, Rana SV, Sinha SK, et al. Serotonin transporter promoter variant: analysis in Indian IBS patients and control population. J Clin Gastroenterol 2009;43:957-961. DOI |
28 | Galligan JJ, Patel BA, Schneider SP, et al. Visceral hypersensitivity in female but not in male serotonin transporter knockout rats. Neurogastroenterol Motil 2013;25:e373-e381. DOI |
29 | Sun J, Wu X, Meng Y, et al. Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of diarrhea-predominant irritable bowel syndrome (D-IBS). BMC Complement Altern Med 2015;15:340. DOI |
30 | Zhou Q, Price DD, Dreher KL, et al. Localized colonic stem cell transplantation enhances tissue regeneration in murine colitis. J Cell Mol Med 2012;16:1900-1915. DOI |
31 | Chen MX, Chen Y, Fu R, Liu SY, Yang QQ, Shen TB. Activation of 5-HT and NR2B contributes to visceral hypersensitivity in irritable bowel syndrome in rats. Am J Transl Res 2016;8:5580-5590. |
32 | Drossman DA, Hasler WL. Rome IV-functional GI disorders: disorders of gut-brain interaction. Gastroenterology 2016;150:1257-1261. DOI |
33 | Oshima T, Miwa H. Epidemiology of functional gastrointestinal disorders in Japan and in the world. J Neurogastroenterol Motil 2015;21:320-329. DOI |
34 | Asano T, Tanaka KI, Tada A, et al. Aminophylline suppresses stressinduced visceral hypersensitivity and defecation in irritable bowel syndrome. Sci Rep 2017;7:40214. DOI |
35 | Camilleri M. Is there a SERT-ain association with IBS? Gut 2004;53:1396-1399. DOI |
36 | Jiang Y, Nie Y, Li Y, Zhang L. Association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in Chinese patients with irritable bowel syndrome. J Gastroenterol Hepatol 2014;29:1186-1191. DOI |
37 | Storr M, Emmerdinger D, Diegelmann J, et al. The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease. PLoS One 2010;5:e9453. DOI |
38 | Abalo R, Chen C, Vera G, et al. In vitro and non-invasive in vivo effects of the cannabinoid-1 receptor agonist AM841 on gastrointestinal motor function in the rat. Neurogastroenterol Motil 2015;27:1721-1735. DOI |
39 | McKenna LB, Schug J, Vourekas A, et al. MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology 2010;139:1654-1664, 1664, e1. DOI |
40 | O'Hara SP, Mott JL, Splinter PL, Gores GJ, LaRusso NF. MicroRNAs: key modulators of posttranscriptional gene expression. Gastroenterology 2009;136:17-25. DOI |
![]() |