Helicobacter pylori Serology Inversely Correlated With the Risk and Severity of Reflux Esophagitis in Helicobacter pylori Endemic Area: A Matched Case-Control Study of 5,616 Health Check-Up Koreans
![]() |
Chung, Su-Jin
(Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center)
Lim, Seon-Hee (Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center) Choi, Jeong-Min (Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center) Kim, Dong-Hee (Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center) Kim, Young-Sun (Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center) Park, Min-Jeong (Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center) Yim, Jeong-Yoon (Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center) Kim, Joo-Sung (Department of Internal Medicine, Seoul National University College of Medicine) Cho, Sang-Heon (Department of Internal Medicine, Seoul National University College of Medicine) Jung, Hyun-Chae (Department of Internal Medicine, Seoul National University College of Medicine) Song, In-Sung (Department of Internal Medicine, Seoul National University College of Medicine) |
1 | Nordenstedt H, Nilsson M, Johnsen R, Lagergren J, Hveem K. Helicobacter pylori infection and gastroesophageal reflux in a population-based study (The HUNT Study). Helicobacter 2007;12:16-22. DOI ScienceOn |
2 | Chung SJ, Kim D, Park MJ, et al. Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 Koreans undergoing health check-ups. Gut 2008;57:1360-1365. DOI ScienceOn |
3 | Shin HR, Jung KW, Won YJ, Park JG; 139 KCCR-affiliated Hospitals. 2002 Annual report of the Korea central cancer registry: based on registered data from 139 hospitals. Cancer Res Treat 2004;36:103-114. DOI ScienceOn |
4 | Hoshihara Y. [Endoscopic findings of GERD.] Nippon Rinsho 2004;62:1459-1464. [Japanese] |
5 | WHO/IASO/IOTF. The Asia-Pacific perspective: redefining obesity and its treatment. Health Communications Australia Pty Ltd 2000:1-55. |
6 | World Health Organization. Obesity: prevention and managing, the global epidemic. Report of a WHO consultation on obesity. Geneva: World Health Organization; 2000:9. |
7 | Wu JC, Sung JJ, Chan FK, et al. Helicobacter pylori infection is associated with milder gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2000;14:427-432. DOI ScienceOn |
8 | Wu JC, Cheung CM, Wong VW, Sung JJ. Distinct clinical characteristics between patients with nonerosive reflux disease and those with reflux esophagitis. Clin Gastroenterol Hepatol 2007;5:690-695. DOI ScienceOn |
9 | El-Omar EM, Oien K, El-Nujumi A, et al. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology 1997;113:15-24. DOI ScienceOn |
10 | Koike T, Ohara S, Sekine H, et al. Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion. Gut 2001;49:330-334. DOI ScienceOn |
11 | Souza RC, Lima JH. Helicobacter pylori and gastroesophageal reflux disease: a review of this intriguing relationship. Dis Esophagus 2009;22:256-263. DOI ScienceOn |
12 | Chung SJ, Kim YS, Yang SY, et al. Prevalence and risk of colorectal adenoma in asymptomatic Koreans aged 40-49 years undergoing screening colonoscopy. J Gastroenterol Hepatol 2010;25:519-525. DOI ScienceOn |
13 | Rowland M, Daly L, Vaughan M, Higgins A, Bourke B, Drumm B. Age-specific incidence of Helicobacter pylori. Gastroenterology 2006;130:65-72. DOI ScienceOn |
14 | Rajendra S, Ackroyd R, Robertson IK, Ho JJ, KarIm N, Kutty KM. Helicobacter pylori, ethnicity, and the gastroesophageal reflux disease spectrum: a study from the East. Helicobacter 2007;12:177-183. DOI ScienceOn |
15 | El-Serag HB, Sonnenberg A. Opposing time trends of peptic ulcer and reflux disease. Gut 1998;43:327-333. DOI ScienceOn |
16 | Yim JY, Kim N, Choi SH, et al. Seroprevalence of Helicobacter pylori in South Korea. Helicobacter 2007;12:333-340. DOI ScienceOn |
17 | Tan HJ, Goh KL. Changing epidemiology of Helicobacter pylori in Asia. J Dig Dis 2008;9:186-189. DOI ScienceOn |
18 | Kim JI, Kim SG, Kim N, et al. Changing prevalence of upper gastrointestinal disease in 28893 Koreans from 1995 to 2005. Eur J Gastroenterol Hepatol 2009;21:787-793. DOI ScienceOn |
19 | Yamaji Y, Mitsushima T, Ikuma H, et al. Inverse background of Helicobacter pylori antibody and pepsinogen in reflux oesophagitis compared with gastric cancer: analysis of 5732 Japanese subjects. Gut 2001;49:335-340. DOI ScienceOn |
20 | Chen TS, Chang FY. The prevalence and risk factors of reflux esophagitis among adult Chinese population in Taiwan. J Clin Gastroenterol 2007;41:819-822. DOI ScienceOn |
21 | Corley DA, Kubo A, Levin TR, et al. Helicobacter pylori and gastroesophageal reflux disease: a case-control study. Helicobacter 2008;13:352-360. DOI ScienceOn |
22 | Anderson LA, Murphy SJ, Johnston BT, et al. Relationship between Helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: results from the FINBAR case-control study. Gut 2008;57:734-739. DOI ScienceOn |
23 | Nam SY, Choi IJ, Ryu KH, Kim BC, Kim CG, Nam BH. Effect of Helicobacter pylori infection and its eradication on reflux esophagitis and reflux symptoms. Am J Gastroenterol 2010;105:2153-2162. DOI ScienceOn |
24 | Raghunath A, Hungin AP, Wooff D, Childs S. Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review. BMJ 2003;326:737-743. |
25 | Cremonini F, Di Caro S, Delgado-Aros S, et al. Meta-analysis: the relationship between Helicobacter pylori infection and gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2003;18:279-289. DOI ScienceOn |
26 | Wu JC, Sung JJ, Ng EK, et al. Prevalence and distribution of Helicobacter pylori in gastroesophageal reflux disease: a study from the East. Am J Gastroenterol 1999;94:1790-1794. DOI ScienceOn |
27 | Grande M, Cadeddu F, Villa M, et al. Helicobacter pylori and gastroesophageal reflux disease. World J Surg Oncol 2008;6:74-80. DOI ScienceOn |
28 | El-Serag HB, Sonnenberg A, Jamal MM, Inadomi JM, Crooks LA, Feddersen RM. Corpus gastritis is protective against reflux oesophagitis. Gut 1999;45:181-185. DOI ScienceOn |
29 | Vicari JJ, Peek RM, Falk GW, et al. The seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease. Gastroenterology 1998;115:50-57. DOI ScienceOn |
30 | Queiroz DM, Rocha GA, Oliveira CA, et al. Role of corpus gastritis and cagA-positive Helicobacter pylori infection in reflux esophagitis. J Clin Microbiol 2002;40:2849-2853. DOI ScienceOn |
31 | Koike T, Ohara S, Sekine H, et al. Helicobacter pylori infection inhibits reflux esophagitis by inducing atrophic gastritis. Am J Gastroenterol 1999;94:3468-3472. DOI ScienceOn |
32 | McColl KE, Watabe H, Derakhshan MH. Role of gastric atrophy in mediating negative association between Helicobacter pylori infection and reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma. Gut 2008;57:721-723. DOI ScienceOn |
33 | Loffeld RJ. Helicobacter pylori, obesity and gastro-oesophageal reflux disease. Is there a relation? A personal view. Neth J Med 2005;63:344-347. |
34 | Yang YJ, Sheu BS, Chang WL, Cheng HC, Yang HB. Increased body mass index after H. pylori eradication for duodenal ulcer predisposes to erosive reflux esophagitis. J Clin Gastroenterol 2009;43:705-710. DOI ScienceOn |
35 | Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. H. pylori virulence and genetic geography. Science 1999;284:1328-1333. DOI ScienceOn |
36 | Queiroz DM, Guerra JB, Rocha GA, et al. IL1B and IL1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis. Gastroenterology 2004;127:73-79. DOI ScienceOn |
37 | Ando T, El-Omar EM, Goto Y, et al. Interleukin 1B proinflammatory genotypes protect against gastro-oesophageal reflux disease through induction of corpus atrophy. Gut 2006;55:158-164. |
38 | Danesh J, Lawrence M, Murphy M, Roberts S, Collins R. Systematic review of the epidemiological evidence on Helicobacter pylori infection and nonulcer or uninvestigated dyspepsia. Arch Intern Med 2000;160:1192-1198. DOI ScienceOn |
![]() |