Browse > Article

Ill-defined Granulomas Demonstrated in Ulcers of the Terminal Ileum and Transverse Colon in a Patient with Typhoid Fever  

Yun, Sang-Gu (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Kim, Nam-Hoon (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Kim, Min-Hwan (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Park, Joo-Hyun (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Bae. Won-Ki (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Kim, Kyung-Ah (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Lee, June-Sung (Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine)
Kim, Han-Sung (Department of Pathology, Ilsan Paik Hospital, Inje University College of Medicine)
Publication Information
Clinical Endoscopy / v.43, no.1, 2011 , pp. 56-59 More about this Journal
Abstract
Typhoid fever, the most serious human salmonellosis, is a systemic infectious disease caused by Salmonella enterica serovar Typhi and is characterized by prolonged fever, bacteremia, and multiplication of the organism within mononuclear phagocytic cells of the liver, spleen, lymph nodes, and Peyer's patches. The characteristic lesion of typhoid fever is an ulceration of the small intestinal lymphoid tissue, particularly the Peyer's patches. The usual histological findings of typhoid ulcer are necrosis and histiocytic proliferation that phagocytizes erythrocytes and degenerated lymphocytes. A granuloma is an unusual histopathological presentation of a typhoid lesion. Even if granulomas have been reported in the bone marrow, liver, and spleen in cases of typhoid fever, granulomas in primary ulcers of the ileum and transverse colon have been reported very rarely. We experienced a case of typhoid fever in which ill-defined granulomas were seen in ulcers of the terminal ileum and transverse colon.
Keywords
Salmonella infection; Typhoid fever; Granuloma;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Cohen JI, Bartlett JA, Corey GR. Extra-intestinal manifestations of salmonella infections. Medicine (Baltimore) 1987;66:349-388.
2 Park KM, Kim NJ, Oh DR, et al. A case of Salmonella enteric serovar Typhi endocarditis with multiple splenic infarctions. Korean J Med 2003;65:702-706.
3 Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ. Typhoid fever. N Engl J Med 2002;347:1770-1782.   DOI   ScienceOn
4 Lamps LW. Infective disorders of the gastrointestinal tract. Histopathology 2007;50:55-63.   DOI   ScienceOn
5 Lee JH, Lee YH, Ahn SH, Choi HS. Granulomatous bone marrow disease - a review of the hematopathologic analysis of 27 cases. Korean J Clin Pathol 1985;5:515-521.
6 Shin BM, Paik IK, Cho HI. Bone marrow pathology of culture proven typhoid fever. J Korean Med Sci 1994;9:57-63.
7 Jin SY, Lee KW, Kim TS. A study on the typhoid granuloma in the bone marrow biopsy of patients with typhoid fever. Korean J Pathol 1986;20:462-469.
8 Paris P. A hepatitis like picture in typhoid fever. Br Med J 1984;289:225-226.
9 Satti MB, al-Freihi H, Ibrahim EM, et al. Hepatic granuloma in Saudi Arabia: a clinicopathological study of 59 cases. Am J Gastroenterol 1990;85:669-674.
10 Mert A, Tabak F, Ozaras R, Ozturk R, Aki H, Aktuglu Y. Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas. Intern Med 2004;43:436-439.   DOI   ScienceOn
11 Bhan MK, Bahl R, Bhatnagar S. Typhoid and paratyphoid fever. Lancet 2005;366:749-762.   DOI   ScienceOn
12 Mandal BK, Mani V. Colonic involvement in salmonellosis. Lancet 1976;1:887-888.
13 Bharadwaj S, Anim JT, Ebrahim F, Aldahham A. Granulomatous inflammatory response in a case of typhoid fever. Med Princ Pract 2009;18:239-241.   DOI   ScienceOn
14 Lee CK, Lee S, Choi JK, Lee ST. Usefulness of Widal test in the diagnosis of typhoid fever. Korean J Infect Dis 2001;33:206-209.   DOI   ScienceOn
15 Cao XT, Kneen R, Nguyen TA, Truong DL, White NJ, Parry CM. A comparative study of ofloxacin and cefixime for treatment of typhoid fever in children. The Dong Nai Pediatric Center Typhoid Study Group. Pediatr Infect Dis J 1999;18:245-248.   DOI   ScienceOn
16 Smith MD, Duong NM, Hoa NT, et al. Comparison of ofloxacin and ceftriaxone for short-course treatment of enteric fever. Antimicrob Agents Chemother 1994;38:1716-1720.   DOI   ScienceOn