Browse > Article

Endoscopic Treatment of 3 Cases of GIST with High Aggressive Behavior  

Cho, Young-Ju (Department of Gastroenterology, Ajou University School of Medicine)
Lee, Kee-Myung (Department of Gastroenterology, Ajou University School of Medicine)
Jung, Kee-Myoung (Department of Gastroenterology, Ajou University School of Medicine)
Lim, Sun-Gyo (Department of Gastroenterology, Ajou University School of Medicine)
Kim, Jin-Hong (Department of Gastroenterology, Ajou University School of Medicine)
Shin, Sung-Jae (Department of Gastroenterology, Ajou University School of Medicine)
Hwang, Jae-Chul (Department of Gastroenterology, Ajou University School of Medicine)
Kim, Young-Bae (Department of Pathology, Ajou University School of Medicine)
Publication Information
Clinical Endoscopy / v.42, no.2, 2011 , pp. 98-104 More about this Journal
Abstract
Gastrointestinal stromal tumors (GISTs) are the most common subepithelial tumor of the gastrointestinal tract. They originate from mesenchymal tissue. Because of difficulties in discriminating between benign and malignant GISTs, the treatment modality is selected on the base of tumor size, mitosis count, location, originating layer, and the presence of complications. Regular follow-up, open resection, or laparoscopic operation were considered main treatments for GISTs. Surgical resection is standard treatment for a huge GIST. However, the treatment method is not determined for GISTs of less than 3 cm that show a benign clinical course. Recently, endoscopic treatment was attempted because of recent endoscope developments and associated devices. We report three cases of gastric GISTs with a high risk of aggressive behavior that were successfully treated by endoscopic resection.
Keywords
GIST; Endoscopic resection;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Saftoiu A, Ciurea T, Georgescu CV, Comanescu V, Popescu C. Curative endoscopic ultrasound-assisted submucosal resection of a gastric stromal tumor. Rom J Gastroenterol 2005;14:177-182.
2 Schnadig ID, Blanke CD. Gastrointestinal stromal tumors: imatinib and beyond. Curr Treat Options Oncol 2006;7:427-437.   DOI   ScienceOn
3 Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002;33:459-465.   DOI   ScienceOn
4 Kim KM, Kang DW, Moon WS, et al; Gastrointestinal Stromal Tumor Committee; The Korean Gastrointestinal Pathology Study Group. Gastrointestinal stromal tumors in Koreans: It's incidence and the clinical, pathologic and immunohistochemical findings. J Korean Med Sci 2005;20:977-984.   DOI   ScienceOn
5 Kim MK, Lee JK, Park ET, et al. Gastrointestinal stromal tumors: clinical, pathologic features and effectiveness of new diagnostic criteria. Korean J Gastroenterol 2004;43:341-348.
6 Sircar K, Hewlett BR, Huizinga JD, Chorneyko K, Berezin I, Riddell RH. Intestinal cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol 1999;23:377-389.   DOI   ScienceOn
7 Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumors (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998;152:1259-1269.
8 Seidal T, Edvardsson H. Expression of c-kit (CD117) and Ki67 provides information about the possible cell of origin and clinical course of gastrointestinal stromal tumours. Histopathology 1999;34:416-424.   DOI   ScienceOn
9 Amin MB, Ma CK, Linden MD, Kubus JJ, Zarbo RJ. Prognostic value of proliferating cell nuclear antigen index in gastric stromal tumors. Correlation with mitotic count and clinical outcome. Am J Clin Pathol 1993;100:428-432.   DOI
10 Palazzo L, Landi B, Cellier C, Cuillerier E, Roseau G, Barbier JP. Endosonographic features predictive of benign and malignant gastrointestinal stromal cell tumors. Gut 2000;46:88-92.   DOI   ScienceOn
11 Grant CS, Kim CH, Farrugia G, Zinsmeister A, Goellner JR. Gastric leiomyosarcoma. Prognostic factors and surgical management. Arch Surg 1991;126:985-989.   DOI   ScienceOn
12 Park YS, Park SW, Kim TI, et al. Endoscopic enucleation of upper-GI submucosal tumors by using an insulated-tip electrosurgical knife. Gastrointest Endosc 2004;59:409-415.   DOI   ScienceOn
13 Rosch T, Sarbia M, Schumacher B, et al. Attempted endoscopic en bloc resection of mucosal and submucosal tumors using insulated-tip knives: a pilot series. Endoscopy 2004;36:788-801.   DOI   ScienceOn
14 Piccinni G, Marzullo A, Angrisano A, Iacobone D, Nacchiero M. Endoscopic resection of benign very low-risk gastric gastrointestinal stromal tumors. Is it enough? Eur J Gastroenterol Hepatol 2007;19:177-179.   DOI   ScienceOn