Browse > Article

Primary NK-/T- Cell Lymphoma of the Esophagus: a Case Presentation and Literature Review  

Kim, Tae-Hyung (Department of Internal Medicine, Korea University College of Medicine)
Ryu, Ho-Sang (Department of Internal Medicine, Korea University College of Medicine)
Kim, Chang-Ha (Department of Internal Medicine, Korea University College of Medicine)
Hong, Ho-Cheol (Department of Internal Medicine, Korea University College of Medicine)
Koh, Jin-Sung (Department of Internal Medicine, Korea University College of Medicine)
Chun, Hoon-Jai (Department of Internal Medicine, Korea University College of Medicine)
Kim, Chang-Duck (Department of Internal Medicine, Korea University College of Medicine)
Kim, In-Sun (Department of Pathology, Korea University College of Medicine)
Publication Information
Clinical Endoscopy / v.41, no.4, 2010 , pp. 208-213 More about this Journal
Abstract
Extranodal natural killer/T-cell lymphoma (ENKL) is an uncommon neoplasm, and it is a subtype of non-Hodgkin's lymphoma. It most commonly presents in the nasal cavity and nasopharynx. But only 10% of ENKL may present on the skin or the gastrointestinal tract and this has a poor prognosis. We report here on a case of CD56+ NK/T-cell lymphoma that limited to the esophagus. A 55-year-old male patient presented with epigastric soreness. Esophagogastroduodenoscopy (EGD) showed well demarcated, longitudinal ulcerative lesions with an irregular base and a discrete margin on the lower esophagus. We performed EGDs and endoscopic biopsies 2 times, but these were insufficient to make a diagnosis. The $3^{rd}$ time, we finally took a big piece of tissue using endoscopic mucosal resection with a cap-fitted panendoscope (EMR-C). The biopsies showed surface ulceration and a heavy lymphoid infiltration and a positive pattern for CD3, CD56 and granzyme B. The pathologic diagnosis was NK/T-cell lymphoma. The patient was treated with concurrent chemoradiation followed by additional chemotherapy and he achieved a complete response.
Keywords
Extranodal NK-T-cell lymphoma; Esophageal primary ulcer; Complete response;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kohrt H, Advani R. Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatment. Leuk Lymphoma 2009;50:1773-1784.   DOI   ScienceOn
2 Kim SJ, Kim K, Kim BS, et al. Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell lymphoma: consortium for improving survival of lymphoma study. J Clin Oncol 2009;27:6027-6032.   DOI   ScienceOn
3 Ko YH, Cho EY, Kim JE, et al. NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status. Histopathology 2004;44:480-489.   DOI   ScienceOn
4 Shih LY, Liang DC. Non-Hodgkin's lymphomas in Asia. Hematol Oncol Clin North Am 1991;5:983-1001.
5 Vose J, Armitage J, Weisenburger D; International T-Cell Lymphoma Project. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008;26:4124-4130.   DOI   ScienceOn
6 Kim JH, Lee JH, Lee J, et al. Primary NK-/T-cell lymphoma of the gastrointestinal tract: clinical characteristics and endoscopic findings. Endoscopy 2007;39:156-160.   DOI   ScienceOn
7 Suzuki R, Takeuchi K, Ohshima K, Nakamura S. Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. Hematol Oncol 2008;26:66-72.   DOI   ScienceOn
8 Oshimi K, Kawa K, Nakamura S, et al. NK-cell neoplasms in Japan. Hematology 2005;10:237-245.   DOI   ScienceOn
9 Paryani S, Hoppe RT, Burke JS, et al. Extralymphatic involvement in diffuse non-Hodgkin's lymphoma. J Clin Oncol 1983;1:682-688.
10 Loehr WJ, Mujahed Z, Zahn FD, Gray GF, Thorbjarnarson B. Primary lymphoma of the gastrointestinal tract: a review of 100 cases. Ann Surg 1969;170:232-238.   DOI   ScienceOn
11 Kim TM, Lee SY, Jeon YK, et al. Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group. Ann Oncol 2008;19:1477-1484.   DOI   ScienceOn