Browse > Article

Associations between Nonalcoholic Fatty Liver Disease and Colorectal Adenoma in Health Screen Examinees  

Choi, Won-Gyu (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Kim, Sang-Jung (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Myung, Seok-Jin (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Choi, Seung-Oh (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Kim, Jung-Hee (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Park, Sang-Woon (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Park, Sang-Jong (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Jang, Eun-Jeong (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Park, Ju-Sang (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Baik, Hyun W. (Department of Internal Medicine, Bundang Jesaeng Hospital, Daejin Medical Center)
Kim, Eun-Ran (Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Beom-Jin (Chung-Ang University College of Medicine)
Publication Information
Clinical Endoscopy / v.41, no.4, 2010 , pp. 201-207 More about this Journal
Abstract
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) and colorectal cancer share several risk factors. However the relationship between NAFLD and colorectal adenoma is unclear. Therefore, we investigated the possibility of an association between NAFLD and colorectal adenoma. Methods: We reviewed the records of 3,106 subjects who had undergone colonoscopy and abdominal ultrasonography between April 2007 and August 2009. Results: The sex ratio (male/female) was 4.94 : 1 and the mean age was $50.6{\pm}9.7$ years in patients with colorectal adenoma; the corresponding numbers were 2.23 : 1 and $45.0{\pm}9.2$ years in patients without colorectal adenoma (p<0.001). The prevalence of NAFLD was 26.0% in the adenoma group and 21.4% in the control group (p=0.013). Additionally, there were positive associations between colorectal adenoma and BMI and lipid profile. Among the risk factors selected by univariate analysis, older age (OR 2.592; 95% CI 2.087~3.219), and being male (OR 2.470; 95% CI 1.878~3.247) were independent risk factors for colorectal adenoma. Patients with NAFLD had more colorectal adenomas (p=0.005) and their adenomas were located more in the proximal colon (p=0.009). Conclusions: NAFLD is not associated with increased risk for colorectal adenoma. However, among patients with NAFLD, colorectal adenomas were likely to be increased in number and they were likely to be located in the proximal colon.
Keywords
Colorectal adenoma; Nonalcoholic fatty liver disease;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 Chung YW, Han DS, Park YK, et al. Association of obesity, serum glucose and lipids with the risk of advanced colorectal adenoma and cancer: a case-control study in Korea. Dig Liver Dis 2006;38:668-672.   DOI   ScienceOn
2 Giorgino F, Laviola L, Eriksson JW. Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiol Scand 2005;183:13-30.   DOI   ScienceOn
3 Shibata M, Kihara Y, Taguchi M, Tashiro M, Otsuki M. Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men. Diabetes Care 2007;30:2940-2944.   DOI   ScienceOn
4 Clark JM, Brancati FL, Diehl AM. Nonalcoholic fatty liver disease. Gastroenterology 2002;122:1649-1657.   DOI   ScienceOn
5 Citarda F, Tomaselli G, Capocaccia R, Barcherini S, Crespi M; Italian Multicentre Study Group. Efficacy in standard clinical practice of colonoscopic polypectomy in reducing colorectal cancer incidence. Gut 2001;48:812-815.   DOI   ScienceOn
6 Jacobs ET, Ahnen DJ, Ashbeck EL, et al. Association between body mass index and colorectal nesoplasia at follow-up colonoscopy: a pooling study. Am J Epidemiol 2009;169:657-666.   DOI   ScienceOn
7 Rider JA, Kirsner JB, Moeller HC, Palmer WL. Polyps of the colon and rectum, their incidence and relationship to carcinoma. Am J Med 1954;16:555-564.   DOI   ScienceOn
8 Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999;116:1413-1419.   DOI   ScienceOn
9 Pessayre D, Berson A, Fromenty B, Mansouri A. Mitochondria in steatohepatitis. Semin Liver Dis 2001;21:57-69.
10 Joseph AE, Saverymuttu SH, al-Sam S, Cook MG, Maxwell JD. Comparision of liver histology with ultrasonography in assessing diffuse parenchymal liver disease. Clin Radiol 1991;43:26-31.   DOI   ScienceOn
11 O'Brien MJ, Winawer SJ, Zauber AG, et al. The national polyp study. Patient and polyp characteristics associated with high-grade dysplasia in colorectal adenomas. Gastroentrology 1990;98:371-379.
12 Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The national polyp study workgroup. N Engl J Med 1993;329:1977-1981.   DOI   ScienceOn
13 Sato Y, Nozaki R, Yamada K, Takano M, Haruma K. Relation between obesity and adenomatous polyps of the large bowel. Dig Endosc 2009;21:154-157.   DOI   ScienceOn
14 Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980;55:434-438.
15 The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc 2003;58(suppl):3S-43S.
16 Endoscopic Classification Review Group. Update on the Paris classification of superficial neoplastic lesions in the digestive tract. Endoscopy 2005;37:570-578.   DOI   ScienceOn
17 Scatarige JC, Scott WW, Donovan PJ, Siegelman SS, Sanders RC. Fatty infiltration of the liver: ultrasonographic and computed tomographic correlation. J Ultrasound Med 1984;3:9-14.
18 Jackman RJ, Mayo CW. The adenoma-carcinoma sequence in cancer of the colon. Surg Gynecol Obstet 1951;93:327-330.
19 Yeon JE. Nonalcoholic fatty liver disease: pathogenesis and treatment. Korean J Med 2006;70:246-252.
20 Wie EK, Ma J, Pallak MN, et al. A prospective study of C-peptide, insulin like growth factor-1, insulin like growth factor binding protein-1 and the risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 2005;14:850-855.   DOI   ScienceOn
21 Yun JW, Cho YK. Clinical impact of non-alcoholic fatty liver disease on other medical disease. Korean J Med 2009;76:25-29.
22 Park JH. Insulin resistance in non-alcoholic fatty liver disease. Korean J Hepatol 2006;12:16-30.
23 Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221-1231.   DOI   ScienceOn
24 Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 2003;37:1202-1219.   DOI   ScienceOn
25 Schoen RE, Tangen CM, Kuller LH, et al. Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst 1999;91:1147-1154.   DOI
26 Mayer RJ. Gastrointestinal tract cancer. In: Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison's principles of internal medicine. Volume 1. 17th ed. New York: McGraw-Hill, 2008:573-578.
27 Joint WHO/FAO Expert Consultation on Diet, Nutrition and the Prevention of Chronic Diseases. Diet, nutrition and the prevention of chronic diseases: Report of a Joint WHO/FAO Expert Consultation. WHO Technical Report Series 916. Geneva: World Health Organization, 2003.
28 World Cancer Research Fund and American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research, 2007.
29 Kaaks R, Toniolo P, Akhmedkhanov A, et al. Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. J Natl Cancer Inst 2000;92:1592-1600.   DOI   ScienceOn
30 Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 2001;131:3109S-3120S.
31 Davidow AL, Neugut AI, Jacobson JS, et al. Recurrent adenomatous polyps and body mass index. Cancer Epidemiol Biomarkers Prev 1996;5:313-315.
32 Frezza EE, Wachtel MS, Chiriva-Internati M. Influence of obesity on the risk of developing colon cancer. Gut 2006;55:285-291.   DOI   ScienceOn
33 Statistics Korea. Annual report on the cause of death statistics in 2006, 2007.
34 Ministry for Health, Welfare and Family Affairs. Annual report of cancer incidence (2007), cancer prevalence (2007) and survival (1993-2007) in Korea, 2009.
35 Ji JH, Park BJ, Park YS, et al. Clinicopathlologic study of colorectal polyps and obesity in Korean adults. Korean J Gastroenterol 2007;49:10-16.
36 Schoen RE. Surveillance after positive and negative colonoscopy examinations: issues, yields, and use. Am J Gastroenterol 2003;98:1237-1246.   DOI   ScienceOn
37 Friis-Liby I, Aldenborg F, Jerlstad P, Rundstrom K, Bjornsson E. High prevalence of metabolic complications in patients with non-alcoholic fatty liver disease. Scand J Gastroenterol 2004;39:864-869.   DOI   ScienceOn
38 Fan JG, Li F, Cai XB, Peng YD, Ao QH, Gao Y. Effects of nonalcoholic fatty liver disease on the development of metabolic disorders. J Gastroenterol Hepatol 2007;22:1086-1091.   DOI   ScienceOn
39 Lee HL, Son BK, Lee OY, et al. Abdominal obesity, insulin resistance, and the risk of colonic adenoma. Korean J Gastroenterol 2007;49:147-151.
40 Kim JH, Lim YJ, Kim YH, et al. Is metabolic syndrome a risk factor for colorectal adenoma? Cancer Epidemiol Biomarkers Prev 2007;16:1543-1546.   DOI   ScienceOn
41 Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Physical activity, obesity and risk for colon cancer and adenoma in men. Ann Intern Med 1995;122:327-334.   DOI   ScienceOn
42 Kim MC, Kim DH, Jeong TH. Risk factors of colorectal polyps in Korean adults. J Korean Acad Farm Med 2002;23:890-896.
43 Hultcrantz R, Gabrielsson N. Patients with persistent elevation of aminotransferases: investigation with ultrasonography, radionuclide imaging and liver biopsy. J Intern Med 1993;233:7-12.   DOI   ScienceOn
44 Park SH, Jeon WK, Kim SH, et al. Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults. J Gastroenterol Hepatol 2006;21:138-143.   DOI   ScienceOn
45 Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995;22:1714-1719.   DOI
46 Lee SY, Kim SK, Kwon CI, et al. Clinical characteristics of health screen examinees with nonalcoholic fatty liver and normal liver function test. Korean J Gastroenterol 2008;52:161-170.
47 Ko ES, Shin JH, Kang EY, Hwang YN, Seo AR, Song SW. Relationship between non-alcoholic fatty liver disease and metabolic syndrome in examiners of a health promotion center in Kyeong-ki do. Korean J Obes 2008;17:37-44.
48 Yamaji Y, Okamoto M, Yoshida H, et al. The effect of body weight reduction on the incidence of colorectal adenoma. Am J Gastroenterol 2008;103:2061-2067.   DOI   ScienceOn