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Recent Eradication Rates of First-line Triple Regimens for H. pylori Infection  

Paek, Na-Young (Department of Family Medicine, Dongguk University-Seoul, Graduate School of Medicine)
Lim, Yun-Jeong (Department of Internal Medicine, Dongguk University-Seoul, Graduate School of Medicine)
Lee, Jong-Ho (Department of Internal Medicine, Dongguk University-Seoul, Graduate School of Medicine)
Kang, Ji-Hun (Department of Internal Medicine, Dongguk University-Seoul, Graduate School of Medicine)
Park, Jeong-Bae (Department of Internal Medicine, Dongguk University-Seoul, Graduate School of Medicine)
Lee, Jin-Ho (Department of Internal Medicine, Dongguk University-Seoul, Graduate School of Medicine)
Publication Information
Clinical Endoscopy / v.41, no.1, 2010 , pp. 5-9 More about this Journal
Abstract
Background/Aims: Decreasing trend of eradication rate of H. pylori using first-line triple regimens (proton pump inhibitor, amoxicillin, clarithromycin) has been issued. Longer therapies may become more popular if there are better results. Recent eradication rate should be examined and proper recommendation should be timely done according to the result. Methods: We examined recent eradication rates of first-line triple regimens and compared eradication rate according to the duration of this first-line therapy for H. pylori infection. The 976 patients received first-line triple therapy at the single center from November, 2005 to October, 2009 were retrospectively analyzed. Urea breath test was done at four to six weeks after completion of eradication therapy. Results: Overall eradication rate of triple regimen by intention to treat analysis was 80.4% (785/976). One week eradication rate has decreasing trend and below 73.3% during recent 2 years. Eradication rate in 2 weeks group (83.3%, 165/198) was significantly higher than 1 week group (73.3%, 198/270) from November, 2007 to October, 2009 (p<0.01). Conclusions: Our results showed that 2 weeks triple regimen should be preferred as first-line therapy for H. pylori eradication.
Keywords
Helicobacter pylori; Eradication;
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Times Cited By KSCI : 12  (Citation Analysis)
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1 Kim NY, Kim JJ, Choe YH, Kim HS, Kim JI, Chung IS. Diagnosis and treatment guidelines for Helicobacter pylori Infection in Korea. Korean J Gastroenterol 2009;54:269-278.   DOI   ScienceOn
2 Sheu BS, Wu JJ, Lo CY, et al. Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther 2002;16:1669-1675.   DOI   ScienceOn
3 Peterson WL, Fendrick AM, Cave DR, Peura DA, Garabedian- Ruffalo SM, Laine L. Helicobacter pylori-related disease: guidelines for testing and treatment. Arch Intern Med 2000; 160:1285-1291.   DOI   ScienceOn
4 Kim BW, Choi MG, Moon SB, et al. Pooled analysis of antibiotics therapy for Helicobacter pylori eradication in Korea. Korean J Gastroenterol 1999;34:42-49.
5 Kim BG, Lee DH, Ye BD, et al. Comparison of 7-day and 14-day proton pump inhibitor-containing triple therapy for Helicobacter pylori eradication: neither treatment duration provides acceptable eradication rate in Korea. Helicobacter 2007;12:31-35.   DOI   ScienceOn
6 Chey WD, Wong BC: Practice Parameters Committee of the American College of Gastroenterology. American college of gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol 2007;102:1808-1825.   DOI   ScienceOn
7 Kim JJ, Reddy R, Lee M, et al. Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea. J Antimicrob Chemother 2001;47: 459-461.   DOI   ScienceOn
8 Kim N. The effect of antibiotic resistance on the eradication of Helicobacter pylori. Korean J Gastroenterol 2006;47:82-86.
9 Song JG, Lee SW, Park JY, et al. Trend in the eradication rates of Helicobacter pylori infection in the last 11 years. Korean J Med 2009;76:303-310.
10 Calvent X, Garcia N, Lóepez L, Gisbert JP, Gené E, Roque M. A meta-analysis of short versus long therapy with a proton pump inhibitor, clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection. Aliment Pharmacol Ther 2000;14:603-609.   DOI   ScienceOn
11 Choi YS, Cheon JH, Lee JY, et al. The trend of eradication rates of first-line triple therapy for Helicobacter pylori infection: single center experience for recent eight years. Korean J Gastroenterol 2006;48:156-161.
12 Egan BJ, Katicic M, O'Connor HJ, O'Morain CA. Treatment of Helicobacter pylori. Helicobacter 2007;1(suppl 1):31S-37S.
13 Howden CW, Hunt RH. Guidelines for the management of Helicobacter pylori infection. Adhoc committee on practice parameters of the American college of gastroenterology. Am J Gastroenterol 1998;93:2330-2338.   DOI
14 Chung WC, Cho YS, Jeong JJ, et al. Eradication rate of Helicobacter pylori according to the diseases and therapeutic regimens, and reinfection rate after successful eradication in a tertiary clinic. Korean J Gastroenterol 2003;41:1-8.
15 Mera R, Fontham ET, Bravo LE, et al. Re: long term follow up of patients treated for Helicobacter pylori infection. Gut 2007;56:436.   DOI   ScienceOn
16 Jung, HS, Shim KN, Baik SJ, et al. Efficacy of levofloxacinbased triple therapy as second-line Helicobacter pylori eradication. Korean J Gastroenterol 2008;51:285-290.
17 Na HS, Hong SJ, Yoon HJ, et al. Eradication rate of first-line and second-line therapy for Helicobacter pylori infection, and reinfection rate after successful eradication. Korean J Gastroenterol 2007;50:170-175.
18 Rhie SY, Kim JG. Changing patterns of antibiotic resistance of Helicobacter pylori in patients with peptic ulcer disease. Korean J Gastroenterol 2007;50:356-362.
19 Choi WH, Park DI, Oh SJ, et al. Effectiveness of 10 daysequential therapy for Helicobacter pylori eradication in Korea. Korean J Gastroenterol 2008;51:280-284.
20 Lee JH, Hong SP, Kwon CI, et al. The efficacy of levofloxacin based triple therapy for Helicobacter pylori eradication. Korean J Gastroenterol 2006;48:19-24.
21 Kang MS, Park DI, Yun JW, et al. Levofloxacin-azithromycin combined triple therapy for Helicobacter pylori eradication. Korean J Gastroenterol 2006;47:30-36.
22 Graham DY, Hong Lu, Yamaoka Y. Therapy for Helicobacter pylori infection can be improved: sequential therapy and beyound. Drugs 2008;68:725-736.   DOI   ScienceOn
23 Malfertheiner P, Megraud F, O'Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III-2000 consensus report. Gut 2007;56:772-781.   DOI   ScienceOn
24 Korean Helicobacter pylori study group. Diagnosis and treatment of Helicobacter pylori infection in Korea. Korean J Gastroenterol 1998;32:275-289.
25 NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH consensus development panel on Helicobacter pylori in peptic ulcer disease. JAMA 1994;272:65-69.   DOI
26 Lee DH. Current status and treatment of Helicobacter pylori infection in Korea. Korean J Gastroenterol 2002;39:153-160.
27 Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-1186.   DOI   ScienceOn
28 You WC, Brown LM, Zhang L, et al. Randomized doubleblind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006;98:974-983.   DOI   ScienceOn
29 Wong WC, Lam SK, Wong WM, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of china: a randomized controlled trial. JAMA 2004;291:187-194.   DOI   ScienceOn
30 Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;1:1311-1315.
31 Amieva MR, EL-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology 2008;134:306-323.   DOI   ScienceOn