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Malignant Transformation of Gastric Gastrointestinal Stromal Tumor in 44 Months Observational Period: A Case Report  

Ryu, Choong-Heon (Department of Internal Medicine, College of Medicine, Inje University)
Kim, Ji-Hyun (Department of Internal Medicine, College of Medicine, Inje University)
Park, Kwan-Sik (Department of Internal Medicine, College of Medicine, Inje University)
Seo, Hyo-Rim (Department of Internal Medicine, College of Medicine, Inje University)
Choi, Yun-Jung (Department of Internal Medicine, College of Medicine, Inje University)
Ha, Seoung-In (Department of Internal Medicine, College of Medicine, Inje University)
Kim, Yoon-Jung (Department of Internal Medicine, College of Medicine, Inje University)
Seol, Sang-Young (Department of Internal Medicine, College of Medicine, Inje University)
Publication Information
Clinical Endoscopy / v.41, no.1, 2010 , pp. 21-25 More about this Journal
Abstract
Gastrointestinal stromal tumor is a common type of gastrointestinal mesenchymal tumor. Depending on the patient's age, compliance and health status, and the level of suspicion of malignancy, tumors ${\leq}$3 cm in size are typically monitored annually by endoscopic ultrasonography. The examination interval can be extended if no size change is noted on consecutive examinations. We report here on a 44-year-old female who presented with abdominal discomfort and displayed no size change of her gastrointestinal stromal tumor on three consecutive endoscopies over a 44-month interval. The patient was diagnosed with malignant gastrointestinal stromal tumor on the basis of the evident ulceration seen on esophagogastroduodenoscopy and the inhomogenous echo noted on the endoscopic ultrasonography and the pathologic findings by gastric wedge resection.
Keywords
Gastrointestinal stromal tumor; Endoscopic ultrasonography;
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1 DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 2000;231:51-58.   DOI   ScienceOn
2 Ando N, Goto H, Niwa Y, et al. The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with immunohistochemical analysis. Gastrointest Endosc 2002;55:37-43.   DOI   ScienceOn
3 Hwang JH, Kimmey MB. The incidental upper gastrointestinal subepithelial mass. Gastroenterology 2004;126:301-307.   DOI   ScienceOn
4 Polkowski M. Endoscopic ultrasound and endoscopic ultrasoundguided fine-needle biopsy for the diagnosis of malignant submucosal tumors. Endoscopy 2005;37:635-645.   DOI   ScienceOn
5 Tetsuji K, Takayuki M, Motohiro E, et al. Gastrointestinal stromal tumor (GIST) of the stomach with an increase in size during the 4-year period of observation, report of case. Stomach and Intestine 2008;43:199-205.
6 Lee SJ, Kim JO, Eun SH, et al. The endoscopic ultrasonographic survey of benign mesenchymal tumor in upper gastrointestinal tract. Korean J Gastrointest Endosc 2007;35: 140-145.
7 Chak A, Canto MI, Rosch T, et al. Endosonographic differentiation of benign and malignant stromal cell tumors. Gastrointest Endosc 1997;45:468-473.   DOI   ScienceOn
8 Evans HL. Smooth muscle tumors of the gastrointestinal tract. A study of 56 cases followed for a minimum of 10 years. Cancer 1985;56:2242-2250.   DOI   ScienceOn
9 Mochizuki Y, Kodera Y, Ito S, et al. Treatment and risk factors for recurrence after curative resection of gastrointestinal stromal tumors of the stomach. World J Surg 2004;28:870- 875.   DOI   ScienceOn
10 Humphris JL, Jones DB. Subepithelial mass lesions in the upper gastrointestinal tract. J Gastroenterol Hepatol 2008;23: 556-566.   DOI   ScienceOn
11 Palazzo L, Landi B, Cellier C, Cuillerier E, Roseau G, Barbier JP. Endosonographic features predictive of benign and malignant gastrointestinal stromal cell tumours. Gut 2000;46:88-92.   DOI   ScienceOn
12 Tio TL, Tytgat GN, den Hartog Jager FC. Endoscopic ultrasonography for the evaluation of smooth muscle tumors in the upper gastrointestinal tract: an experience with 42 cases. Gastrointest Endosc 1990;36:342-350.   DOI   ScienceOn
13 Franquemont DW. Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol 1995;103:41-47.   DOI
14 Miettinen M, El-Rifai W, L HLS, Lasota J. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol 2002;33:478-483.   DOI   ScienceOn
15 Rader AE, Avery A, Wait CL, McGreevey LS, Faigel D, Heinrich MC. Fine-needle aspiration biopsy diagnosis of gastrointestinal stromal tumors using morphology, immunocytochemistry, and mutational analysis of c-kit. Cancer 2001;93:269- 275.   DOI
16 Miettinen M, Lasota J. Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001; 438:1-12.   DOI   ScienceOn
17 Hwang JH, Rulyak SD, Kimmey MB; American Gastroenterological Association Institute. American gastroenterological association institute technical review on the management of gastric subepithelial masses. Gastroenterology 2006;130:2217-2228.   DOI   ScienceOn
18 Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF. Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Ann Surg Oncol 2000;7:705-712.   DOI   ScienceOn
19 Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002;33:459-465.   DOI   ScienceOn
20 Rubin BP. Gastrointestinal stromal tumours: an update. Histopathology 2006;48:83-96.   DOI   ScienceOn