Browse > Article

An Outbreak of Glutaraldehyde Colitis  

Chae, Hiun-Suk (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Kim, Sung-Soo (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Lee, Kang-Moon (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Kim, Byung-Wook (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Han, Suk-Won (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Lee, Chang-Don (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Choi, Kyou-Yong (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Chung, In-Sik (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
Sun, Hee-Sik (Departments of Internal Medicine, College of Medicine, The Catholic University of Korea)
An, Chang-Hyuk (Departments of Surgery, College of Medicine, The Catholic University of Korea)
Lee, Eun-Jung (Departments of Clinical Pathology, College of Medicine, The Catholic University of Korea)
Publication Information
Clinical Endoscopy / v.24, no.5, 2002 , pp. 273-277 More about this Journal
Abstract
Background/Aims: Disinfecting solutions of endoscope, including glutaraldehyde cause colonic damage if allowed to contact mucosa. Glutaraldehyde colitis occurs due to inadvertent contact during colonoscopy and sigmoidoscopy. We experienced unexpectedly glutaraldehyde colitis. We describe symptoms, signs and clinical courses of glutaraldehyde colitis. Methods: Colonoscopy and sigmoidoscopy were performed at one session after bowel cleaning with polyethylene glycol ingestion 2.3 liters. Within 24 hours, all of them visited emergency room because of bloody diarrhea, vomiting and colicky abdominal pain. We performed sigmoidoscopy again in one patient. Results: Sigmoidoscopic findings was diffuse edematous, hyperemic mucosa and shallow ulcerations similar to the findings of ischemic colitis. But, un-contacted mucosa was normal findings which can be completely distinguished from contacted mucosa. Microscopically, colonic mucosa showed edema, polymorphonuclear leukocytes infiltration and fibroprulent exudates with surface erosions. Laboratory findings were non-specific except leukocytosis of peripheral blood. Both bacterial cultures of blood and stool were negative in all patients. Symptoms subsided within 7 days and duration of admission is almost within 9 days. All of patients recovered completely without any complication. Conclusions: The clinical features of glutaraldehyde colitis resembled colonic ischemia in symptoms and endoscopic findings. This complication should be suspected in patients who develop hemorrhagic colitis suddenly after undergoing colonoscopy.
Keywords
Glutaraldehyde colitis; Colonoscopy;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Fukunaga K, Kbatibi A. Glutaraldehyde colitis: a complication of screening flexible sigmoidoscopy in the primary care setting. Ann Intern Med 2000;15:133-315
2 Burtin P, Ruget O, Petit R, Boyer J. Glutaraldehyde-induced proctitis after endorectal ultrasound examination: a higher risk of incidence than expected?. Gastrointest Endosc 1993;39:859-860   DOI   ScienceOn
3 Zissin R, Gayer G, Maor-Kendler Y. CT findings of glutaraldehyde colitis: a report of two cases. Clin Radiol 1999;54:123-125   DOI   ScienceOn
4 West AB, Kuan SF, Bennick M, Lagarde S. Glutaraldehyde colitis following endoscopy: clinical and pathological features and investigation of an outbreak. Gastroenterology 1995;108:1250-1255   DOI   ScienceOn
5 Durante L, Zulty JC, Israel E, et al. Investigation of an outbreak of bloody diarrhea: association with endoscopic cleaning solution and demonstration of lesions in an animal model. Am J Med 1992;92:476-480   DOI   ScienceOn
6 Babb JR, Bradley CR. The mechanics of endoscope disinfection. J Hosp Infect 1991;18:130-135   DOI   ScienceOn
7 Dietze B, Neumann H, Mansmann U, Martiny H. Determination of glutaraldehyde residues on flexible endoscopes after chemothermal treatment in an endoscope washer-disinfector. Endoscopy 2001;33:529-532   DOI   ScienceOn
8 Ryan CK, Potter GD. Disinfectant colitis. Rinse as well as you wash. J Clin Gastroenterol 1995;21:6-9   DOI   PUBMED   ScienceOn
9 O'connor HJ, Axon ATR. Gastrointestinal endoscopy: infection and disinfection. Gut 1983;24:1067-1077   DOI   ScienceOn
10 Birnbaum BA, Gordon RB, Jacobs JE. Glutaraldehyde colitis: Radiologic findings. Radiology 1995;195:131-134   DOI   PUBMED
11 Rozen P, Somjen GJ, Baratz M, Kimel R, Arber N, Gilat T. Endoscope-induced colitis: description, probable cause by glutaraldehyde, and prevention. Gastrointest Endosc 1994;40:547-553   DOI   PUBMED   ScienceOn