Browse > Article
http://dx.doi.org/10.3345/cep.2019.00780

Pollen-food allergy syndrome in children  

Jeon, You Hoon (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.63, no.12, 2020 , pp. 463-468 More about this Journal
Abstract
Pollen-food allergy syndrome (PFAS) is an immunoglobulin E-mediated immediate allergic reaction caused by cross-reactivity between pollen and the antigens of foods-such as fruits, vegetables, or nuts-in patients with pollen allergy. A 42.7% prevalence of PFAS in Korean pediatric patients with pollinosis was recently reported. PFAS is often called oral allergy syndrome because of mild symptoms such as itching, urticaria, and edema mainly in the lips, mouth, and pharynx that appear after food ingestion. However, reports of systemic reactions such as anaphylaxis have been increasing recently. This diversity in the degree of symptoms is related to the types of trigger foods and the characteristics of allergens, such as heat stability. When pediatric patients with pollen allergy are treated, attention should be paid to PFAS and an active effort should be made to diagnose it.
Keywords
Pollen; Food hypersensitivity; Child;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Eriksson NE, Formgren H, Svenonius E. Food hypersensitivity in patients with pollen allergy. Allergy 1982;37:437-43.   DOI
2 Cho YS, Lim YJ, Lee JC, Kim SH, Lim MK, Yoo B, et al. Oral allergy syndrome in pollen - sensitized patients. J Asthma Allergy Clin Immunol 1998;18:458-65.
3 Dondi A, Tripodi S, Panetta V, Asero R, Businco AD, Bianchi A, et al. Pollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity. Pediatr Allergy Immunol 2013;24:742-51.   DOI
4 Brown CE, Katelaris CH. The prevalence of the oral allergy syndrome and pollen-food syndrome in an atopic paediatric population in southwest Sydney. J Paediatr Child Health 2014;50:795-800.   DOI
5 Kim JH, Oh JW, Lee HB, Kim SW, Kang IJ, Kook MH, et al. Changes in sensitization rate to weed allergens in children with increased weeds pollen counts in Seoul metropolitan area. J Korean Med Sci 2012;27:350-5.   DOI
6 Tuft L, Blumstein GI. Studies in food allergy: II. sensitization to fresh fruits: clinical and experimental observations. J Allergy 1942;13:574-82.   DOI
7 Bircher AJ, Van Melle G, Haller E, Curty B, Frei PC. IgE to food allergens are highly prevalent in patients allergic to pollens, with and without symptoms of food allergy. Clin Exp Allergy 1994;24:367-74.   DOI
8 Price A, Ramachandran S, Smith GP, Stevenson ML, Pomeranz MK, Cohen DE. Oral allergy syndrome (pollen-food allergy syndrome). Dermatitis 2015;26:78-88.   DOI
9 Kazatsky AM, Wood RA. Classification of food allergens and crossreactivity. Curr Allergy Asthma Rep 2016;16:22.   DOI
10 Kim KI, Lee B, Min TK, Lee J, Pyun BY, Jeon YH. Clinical characteristics of oral allergy syndrome in children with atopic dermatitis and birch sensitization: a single center study. J Korean Med Sci 2019;34:e11.   DOI
11 Valenta R, Kraft D. Type 1 allergic reactions to plant-derived food: a consequence of primary sensitization to pollen allergens. J Allergy Clin Immunol 1996;97:893-5.   DOI
12 Breiteneder H, Ebner C. Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 2000;106(1 Pt 1): 27-36.   DOI
13 Kazemi-Shirazi L, Pauli G, Purohit A, Spitzauer S, Froschl R, HoffmannSommergruber K, et al. Quantitative IgE inhibition experiments with purified recombinant allergens indicate pollen-derived allergens as the sensitizing agents responsible for many forms of plant food allergy. J Allergy Clin Immunol 2000;105(1 Pt 1):116-25.   DOI
14 Webber CM, England RW. Oral allergy syndrome: a clinical, diagnostic, and therapeutic challenge. Ann Allergy Asthma Immunol 2010;104:101-8.   DOI
15 Amlot PL, Kemeny DM, Zachary C, Parkes P, Lessof MH. Oral allergy syndrome (OAS): symptoms of IgE-mediated hypersensitivity to foods. Clin Allergy 1987;17:33-42.   DOI
16 Cuesta-Herranz J, Lazaro M, Figueredo E, Igea JM, Umpierrez A, De-Las-Heras M. Allergy to plant-derived fresh foods in a birch- and ragweed-free area. Clin Exp Allergy 2000;30:1411-6.   DOI
17 Wensing M, Akkerdaas JH, van Leeuwen WA, Stapel SO, BruijnzeelKoomen CA, Aalberse RC, et al. IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance. J Allergy Clin Immunol 2002;110: 435-42.   DOI
18 Bedolla-Barajas M, Kestler-Gramajo A, Alcala-Padilla G, MoralesRomero J. Prevalence of oral allergy syndrome in children with allergic diseases. Allergol Immunopathol (Madr) 2017;45:127-33.   DOI
19 Sicherer SH. Clinical implications of cross-reactive food allergens. J Allergy Clin Immunol 2001;108:881-90.   DOI
20 Ebner C, Birkner T, Valenta R, Rumpold H, Breitenbach M, Scheiner O, et al. Common epitopes of birch pollen and apples: studies by western and northern blot. J Allergy Clin Immunol 1991;88:588-94.   DOI
21 Ballmer-Weber BK, Vieths S, Luttkopf D, Heuschmann P, Wuthrich B. Celery allergy confirmed by double-blind, placebo-controlled food challenge: a clinical study in 32 subjects with a history of adverse reactions to celery root. J Allergy Clin Immunol 2000;106:373-8.   DOI
22 Moller C. Effect of pollen immunotherapy on food hypersensitivity in children with birch pollinosis. Ann Allergy 1989;62:343-5.
23 Kondo Y, Urisu A. Oral allergy syndrome. Allergol Int 2009;58:485-91.   DOI
24 Luttkopf D, Ballmer-Weber BK, Wuthrich B, Vieths S. Celery allergens in patients with positive double-blind placebo-controlled food challenge. J Allergy Clin Immunol 2000;106:390-9.   DOI
25 Ebo DG, Hagendorens MM, Bridts CH, De Clerck LS, Stevens WJ. Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy. Clin Exp Allergy 2004;34:137-44.   DOI
26 Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, et al. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000; 122:20-32.
27 Kim MA, Kim DK, Yang HJ, Yoo Y, Ahn Y, Park HS, et al. Pollen-food allergy syndrome in Korean pollinosis patients: a nationwide survey. Allergy Asthma Immunol Res 2018;10:648-61.   DOI
28 Choi JH, Lee CY. Oral allergy syndrome. Allergy Asthma Respir Dis 2018;6:85-9.   DOI
29 Ballmer-Weber BK, Vieths S, Luttkopf D, Heuschmann P, Wuthrich B. Celery allergy confirmed by double-blind, placebo-controlled food challenge: a clinical study in 32 subjects with a history of adverse reactions to celery root. J Allergy Clin Immunol 2000;106:373-8.   DOI
30 Midoro-Horiuti T, Brooks EG, Goldblum RM. Pathogenesis-related proteins of plants as allergens. Ann Allergy Asthma Immunol 2001;87: 261-71.   DOI
31 Pascal M, Munoz-Cano R, Reina Z, Palacin A, Vilella R, Picado C, et al. Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy 2012;42:1529-39.   DOI
32 Osterballe M, Scheller R, Stahl Skov P, Andersen KE, Bindslev-Jensen C. Diagnostic value of scratch-chamber test, skin prick test, histamine release and specific IgE in birch-allergic patients with oral allergy syndrome to apple. Allergy 2003;58:950-3.   DOI
33 Asero R. Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. Clin Exp Allergy 1998;28:1368-73.   DOI
34 Ortolani C, Ispano M, Pastorello EA, Ansaloni R, Magri GC. Comparison of results of skin prick tests (with fresh foods and commercial food extracts) and RAST in 100 patients with oral allergy syndrome. J Allergy Clin Immunol 1989;83:683-90.   DOI
35 Barbi E, Berti I, Longo G. Food allergy: from the of loss of tolerance induced by exclusion diets to specific oral tolerance induction. Recent Pat Inflamm Allergy Drug Discov 2008;2:212-4.   DOI
36 Egger M, Mutschlechner S, Wopfner N, Gadermaier G, Briza P, Ferreira F. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. Allergy 2006;61:461-76.   DOI
37 Mari A, Iacovacci P, Afferni C, Barletta B, Tinghino R, Di Felice G, et al. Specific IgE to cross-reactive carbohydrate determinants strongly affect the in vitro diagnosis of allergic diseases. J Allergy Clin Immunol 1999; 103:1005-11.   DOI
38 Mittag D, Vieths S, Vogel L, Becker WM, Rihs HP, Helbling A, et al. Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens. J Allergy Clin Immunol 2004;113:148-54.   DOI
39 Hofmann A, Burks AW. Pollen food syndrome: update on the allergens. Curr Allergy Asthma Rep 2008;8:413-7.   DOI
40 Sloane D, Sheffer A. Oral allergy syndrome. Allergy Asthma Proc 2001; 22:321-5.
41 Asero R. Fennel, cucumber, and melon allergy successfully treated with pollen-specific injection immunotherapy. Ann Allergy Asthma Immunol 2000;84:460-2.   DOI
42 Clark AT, Skypala I, Leech SC, Ewan PW, Dugue P, Brathwaite N, et al. British Society for Allergy and Clinical Immunology guidelines for the management of egg allergy. Clin Exp Allergy 2010;40:1116-29.   DOI
43 Pastorello EA, Stocchi L, Pravettoni V, Bigi A, Schilke ML, Incorvaia C, et al. Role of the elimination diet in adults with food allergy. J Allergy Clin Immunol 1989;84(4 Pt 1):475-83.   DOI
44 Asero R. How long does the effect of birch pollen injection SIT on apple allergy last? Allergy 2003;58:435-8.   DOI
45 Mari A, Ballmer-Weber BK, Vieths S. The oral allergy syndrome: improved diagnostic and treatment methods. Curr Opin Allergy Clin Immunol 2005;5:267-73.   DOI
46 Kelso JM, Jones RT, Tellez R, Yunginger JW. Oral allergy syndrome successfully treated with pollen immunotherapy. Ann Allergy Asthma Immunol 1995;74:391-6.
47 Ebo DG, Bridts CH, Verweij MM, De Knop KJ, Hagendorens MM, De Clerck LS, et al. Sensitization profiles in birch pollen-allergic patients with and without oral allergy syndrome to apple: lessons from multiplexed component-resolved allergy diagnosis. Clin Exp Allergy 2010;40:339-47.   DOI
48 Ma S, Sicherer SH, Nowak-Wegrzyn A. A survey on the management of pollen-food allergy syndrome in allergy practices. J Allergy Clin Immunol 2003;112:784-8.   DOI
49 van Ree R. Clinical importance of non-specific lipid transfer proteins as food allergens. Biochem Soc Trans 2002;30(Pt 6):910-3.   DOI
50 Osterballe M, Hansen TK, Mortz CG, Bindslev-Jensen C. The clinical relevance of sensitization to pollen-related fruits and vegetables in unselected pollen-sensitized adults. Allergy 2005;60:218-25.   DOI